Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE Study
Ramsey, Timothy L, Liu, Qian, Massey, Bill W, Brennan, Mark D
Published in Schizophrenia research (01.09.2013)
Published in Schizophrenia research (01.09.2013)
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Journal Article
Cryptosphaerolide, a Cytotoxic Mcl-1 Inhibitor from a Marine-Derived Ascomycete Related to the Genus Cryptosphaeria
Oh, Hyuncheol, Jensen, Paul R, Murphy, Brian T, Fiorilla, Catherine, Sullivan, John F, Ramsey, Timothy, Fenical, William
Published in Journal of natural products (Washington, D.C.) (28.05.2010)
Published in Journal of natural products (Washington, D.C.) (28.05.2010)
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Journal Article
Selective Killing of Transformed Cells by Cyclin/Cyclin-Dependent Kinase 2 Antagonists
Chen, Ying-Nan P., Sharma, Sushil K., Ramsey, Timothy M., Jiang, Li, Martin, Mary S., Baker, Kayla, Adams, Peter D., Bair, Kenneth W., Kaelin, William G.
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.1999)
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Journal Article
Evidence for a SULT4A1 haplotype correlating with baseline psychopathology and atypical antipsychotic response
Ramsey, Timothy L, Meltzer, Herbert Y, Brock, Guy N, Mehrotra, Bharat, Jayathilake, Karu, Bobo, William V, Brennan, Mark D
Published in Pharmacogenomics (01.04.2011)
Published in Pharmacogenomics (01.04.2011)
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AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma
SATHORNSUMETEE, Sith, HJELMELAND, Anita B, BIGNER, Darell D, FRIEDMAN, Henry S, RICH, Jeremy N, KEIR, Stephen T, MCLENDON, Roger E, BATT, David, RAMSEY, Timothy, YUSUFF, Naeem, AHMED RASHEED, B. K, KIERAN, Mark W, LAFORME, Andrea
Published in Cancer research (Chicago, Ill.) (01.09.2006)
Published in Cancer research (Chicago, Ill.) (01.09.2006)
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Journal Article
Sulfotransferase 4A1 Haplotype 1 (SULT4A1-1) Is Associated With Decreased Hospitalization Events in Antipsychotic-Treated Patients With Schizophrenia
Liu, Qian, Ramsey, Timothy L, Meltzer, Herbert Y, Massey, Bill W, Padmanabhan, Saranya, Brennan, Mark D
Published in Primary care companion for CNS disorders (2012)
Published in Primary care companion for CNS disorders (2012)
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Journal Article
Estrogen Receptor β Isoforms Exhibit Differences in Ligand-Activated Transcriptional Activity in an Estrogen Response Element Sequence-Dependent Manner
Ramsey, Timothy L, Risinger, Kelly E, Jernigan, Sarah C, Mattingly, Kathleen A, Klinge, Carolyn M
Published in Endocrinology (Philadelphia) (01.01.2004)
Published in Endocrinology (Philadelphia) (01.01.2004)
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Journal Article
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3: Synthesis of Fragment C15 - 21
Mickel, Stuart J, Sedelmeier, Gottfried H, Niederer, Daniel, Schuerch, Friedrich, Koch, Guido, Kuesters, E, Daeffler, Robert, Osmani, Adnan, Seeger-Weibel, Manuela, Schmid, E, Hirni, Alfred, Schaer, Karl, Gamboni, Remo, Bach, Andrew, Chen, Stephen, Chen, Weichun, Geng, Peng, Jagoe, Christopher T, Kinder, Frederick R, Lee, George T, McKenna, Joseph, Ramsey, Timothy M, Repič, Oljan, Rogers, Larry, Shieh, Wen-Chung, Wang, Run-Ming, Waykole, Liladhar
Published in Organic process research & development (01.01.2004)
Published in Organic process research & development (01.01.2004)
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Journal Article
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C7 - 24
Mickel, Stuart J, Sedelmeier, Gottfried H, Niederer, Daniel, Schuerch, Friedrich, Seger, Manuela, Schreiner, Klaus, Daeffler, Robert, Osmani, Adnan, Bixel, Dominique, Loiseleur, Olivier, Cercus, Jacques, Stettler, Hans, Schaer, Karl, Gamboni, Remo, Bach, Andrew, Chen, Guang-Pei, Chen, Weichun, Geng, Peng, Lee, George T, Loeser, Eric, McKenna, Joseph, Kinder, Frederick R, Konigsberger, Kurt, Prasad, Kapa, Ramsey, Timothy M, Reel, Noela, Repič, Oljan, Rogers, Larry, Shieh, Wen-Chung, Wang, Run-Ming, Waykole, Liladhar, Xue, Song, Florence, Gordon, Paterson, Ian
Published in Organic process research & development (01.01.2004)
Published in Organic process research & development (01.01.2004)
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Journal Article
A Systematic Evaluation of the Bleomycin A2 l-Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage
Boger, Dale L, Ramsey, Timothy M, Cai, Hui, Hoehn, Silvia T, Stubbe, JoAnne
Published in Journal of the American Chemical Society (16.09.1998)
Published in Journal of the American Chemical Society (16.09.1998)
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Journal Article
Definition of the Effect and Role of the Bleomycin A2 Valerate Substituents: Preorganization of a Rigid, Compact Conformation Implicated in Sequence-Selective DNA Cleavage
Boger, Dale L, Ramsey, Timothy M, Cai, Hui, Hoehn, Silvia T, Stubbe, JoAnne
Published in Journal of the American Chemical Society (16.09.1998)
Published in Journal of the American Chemical Society (16.09.1998)
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Journal Article
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Chen, Ying-Nan P, LaMarche, Matthew J, Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G, Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G, Dobson, Jason R, Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R, Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D, Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J, Sellers, William R, Stams, Travis, Fortin, Pascal D
Published in Nature (London) (07.07.2016)
Published in Nature (London) (07.07.2016)
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Randomized window of opportunity trial evaluating high-dose vitamin D in breast cancer patients
Arnaout, Angel, Robertson, Susan, Pond, Gregory R., Vieth, Reinhold, Jeong, Ahwon, Hilton, John, Ramsey, Timothy, Clemons, Mark
Published in Breast cancer research and treatment (01.11.2019)
Published in Breast cancer research and treatment (01.11.2019)
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