Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats
Yanier Núñez Figueredo, Jeney Ramírez-Sanchez, Gisele Hansel, Gilberto L. Pardo-Andreu, Nelson Merino, Guillermo Aparicio, Rene Delgado-Hernández, Laura García-Pupo, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O. Souza
Published in Journal of pharmacy & pharmacognosy research (01.07.2016)
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Published in Journal of pharmacy & pharmacognosy research (01.07.2016)
Journal Article
중추신경계 및 혈관계에 대한 활성을 가진 벤조디아제핀 생성물
RAMIREZ SANCHEZ JENEY, NUNEZ FIGUEREDO YANIER, FONSECA FONSECA LUIS ARTURO, VERDECIA REYES YAMILA, PADRON YAQUIS SAUL ALEJANDRO, BARZAGA FERNANDEZ PEDRO GILBERTO, DELGADO HERNANDEZ RENE, PARDO ANDREU GILBERTO LAZARO, WONG GUERRA MAYLIN, GONZALEZ ALFONSO NICTE, OCHOA RODRIGUEZ ESTAEL, GARRIDO SUAREZ BARBARA BEATRIZ
Year of Publication 09.03.2021
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Year of Publication 09.03.2021
Patent
중추신경계 및 혈관계 질환의 치료를 위한 페놀 화합물 및 1,4-디하이드로피리딘에 융합된 벤조디아제핀과 그것의 조합
MONDELO RODRIGUEZ ABEL, FONSECA FONSECA LUIS ARTURO, PADRON YAQUIS SAUL ALEJANDRO, BARZAGA FERNANDEZ PEDRO GILBERTO, CANAAN HADEN NAVARRO CLAUDIA AMANDA, OCHOA RODRIGUEZ ESTAEL, RAMIREZ SANCHEZ JENEY, NUNEZ FIGUEREDO YANIER, VERDECIA REYES YAMILA, DELGADO HERNANDEZ RENE, PARDO ANDREU GILBERTO LAZARO, WONG GUERRA MAYLIN, GONZALEZ ALFONSO NICTE
Year of Publication 09.03.2021
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Year of Publication 09.03.2021
Patent
Characterization of the anxiolytic and sedative profile of JM-20: a novel benzodiazepine-dihydropyridine hybrid molecule
Figueredo, Yanier Nuñez, Rodríguez, Estael Ochoa, Reyes, Yamila Verdecia, Domínguez, Carmen Carrillo, Parra, Alicia Lagarto, Sánchez, Jeney Ramirez, Hernández, René Delgado, Verdecia, Marlene Porto, Pardo Andreu, Gilberto L
Published in Neurological research (New York) (01.10.2013)
Published in Neurological research (New York) (01.10.2013)
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Journal Article
KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity
Fonseca-Fonseca, Luis Arturo, Nuñez-Figueredo, Yanier, Sánchez, Jeney Ramírez, Guerra, Maylin Wong, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Hernádez, René Delgado, Menezes-Filho, Noelio J., Costa, Teresa Cristina Silva, de Santana, Wagno Alcântara, Oliveira, Joana L., Segura-Aguilar, Juan, da Silva, Victor Diogenes Amaral, Costa, Silva Lima
Published in Neurotoxicity research (01.08.2019)
Published in Neurotoxicity research (01.08.2019)
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Journal Article
Mitochondrial involvement in memory impairment induced by scopolamine in rats
Wong-Guerra, Maylin, Jiménez-Martin, Javier, Pardo-Andreu, Gilberto L, Fonseca-Fonseca, Luis A, Souza, Diogo O, de Assis, Adriano M, Ramirez-Sanchez, Jeney, Del Valle, Roberto Menéndez-Soto, Nuñez-Figueredo, Yanier
Published in Neurological research (New York) (03.07.2017)
Published in Neurological research (New York) (03.07.2017)
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Journal Article
Correlational assessment of the effects of JM-20 in a rat model of parkinsonism
Fonseca-Fonseca, Luis Arturo, Fuentes, Nancy Pavón, Sánchez, Jeney Ramírez, Iglesias, Ángela Tuero, Outeiro, Tiago Fleming, Silva, Víctor Diogenes Amaral da, Costa, Silvia Lima, Núñez-Figueredo, Yanier
Published in Behavioural brain research (05.01.2025)
Published in Behavioural brain research (05.01.2025)
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Journal Article
Antioxidant and Neuroprotective Effects of KM-34, A Novel Synthetic Catechol, Against Oxidative Stress-Induced Neurotoxicity
Nuñez-Figueredo, Yanier, Ramirez-Sanchez, Jeney, Issac, Yeniceis Alcantara, Ochoa-Rodriguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernandez, Rene, Souza, Diogo O, Andreu, Gilberto L Pardo
Published in Drug research (01.05.2018)
Published in Drug research (01.05.2018)
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Journal Article
JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson’s disease
Fonseca-Fonseca, Luis Arturo, Wong-Guerra, Maylin, Ramírez-Sánchez, Jeney, Montano-Peguero, Yanay, Padrón Yaquis, Alejandro Saúl, Rodríguez, Abel Mondelo, da Silva, Víctor Diógenes Amaral, Costa, Silvia Lima, Pardo-Andreu, Gilberto L., Núñez-Figueredo, Yanier
Published in Neuroscience letters (18.01.2019)
Published in Neuroscience letters (18.01.2019)
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Journal Article
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain
Ramírez-Sánchez, Jeney, Pires, Elisa Nicoloso Simões, Meneghetti, André, Hansel, Gisele, Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O
Published in Molecular neurobiology (2019)
Published in Molecular neurobiology (2019)
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Journal Article
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: Mitochondrial protection and antioxidant properties
Fonseca-Fonseca, Luis Arturo, da Silva, Víctor Diogenes Amaral, Wong-Guerra, Maylin, Ramírez-Sánchez, Jeney, Yaquis, Alejandro Saúl Padrón, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, de Araújo, Fillipe Mendes, Santana, Rejane Conceição, Outeiro, Tiago Fleming, Costa, Silvia Lima, Núñez-Figueredo, Yanier
Published in Neurotoxicology (Park Forest South) (01.01.2021)
Published in Neurotoxicology (Park Forest South) (01.01.2021)
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Journal Article
JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats
Wong-Guerra, Maylin, Montano-Peguero, Yanay, Ramírez-Sánchez, Jeney, Jiménez-Martin, Javier, Fonseca-Fonseca, Luis Arturo, Hernández-Enseñat, Daniela, Nonose, Yasmine, Valdés, Odalys, Mondelo-Rodriguez, Abel, Ortiz-Miranda, Yaquelin, Bergado, Gretchen, Carmenate, Tania, Soto del Valle, Roberto Menéndez, Pardo-Andreu, Gilberto, Outeiro, Tiago Fleming, Padrón-Yaquis, Alejandro Saúl, Martimbianco de Assis, Adriano, O Souza, Diogo, Nuñez-Figueredo, Yanier
Published in Neurotoxicology (Park Forest South) (01.12.2021)
Published in Neurotoxicology (Park Forest South) (01.12.2021)
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Journal Article
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion
Ramírez-Sánchez, Jeney, Wong-Guerra, Maylin, Fonseca-Fonseca, Luis Arturo, Simões-Pires, Elisa Nicoloso, García-Pupo, Laura, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O., Pardo-Andreu, Gilberto L., Nuñez-Figueredo, Yanier
Published in European journal of pharmacology (15.05.2021)
Published in European journal of pharmacology (15.05.2021)
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Journal Article
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Hansel, Gisele, Simões Pires, Elisa Nicoloso, Merino, Nelson, Valdes, Odalys, Delgado-Hernández, René, Parra, Alicia Lagarto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Salbego, Christianne, Costa, Silvia L., Souza, Diogo O., Pardo-Andreu, Gilberto L.
Published in Neuropharmacology (01.10.2014)
Published in Neuropharmacology (01.10.2014)
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Journal Article
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+ -induced mitochondrial impairment
Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Naal, Zeki, Muller, Alexandre Pastoris, Portela, Luis Valmor, Souza, Diogo O
Published in Brain research bulletin (01.10.2014)
Published in Brain research bulletin (01.10.2014)
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Journal Article
Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Pardo Andreu, Gilberto L., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Souza, Diogo O.
Published in Pharmacological reports (01.08.2018)
Published in Pharmacological reports (01.08.2018)
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Journal Article
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway
Ramírez-Sánchez, Jeney, Simões Pires, Elisa Nicoloso, Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L., Fonseca-Fonseca, Luis Arturo, Ruiz-Reyes, Alberto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Souza, Diogo O., Salbego, Christianne
Published in Neurochemistry international (01.11.2015)
Published in Neurochemistry international (01.11.2015)
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Journal Article
JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment
Wong-Guerra, Maylin, Jiménez-Martin, Javier, Fonseca-Fonseca, Luis Arturo, Ramírez-Sánchez, Jeney, Montano-Peguero, Yanay, Rocha, Joao Batista, D Avila, Fernanda, de Assis, Adriano M, Souza, Diogo Onofre, Pardo-Andreu, Gilberto L, Del Valle, Roberto Menéndez-Soto, Lopez, Guillermo Aparicio, Martínez, Odalys Valdés, García, Nelson Merino, Mondelo-Rodríguez, Abel, Padrón-Yaquis, Alejandro Saúl, Nuñez-Figueredo, Yanier
Published in Neurological research (New York) (04.05.2019)
Published in Neurological research (New York) (04.05.2019)
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Journal Article
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Porto-Verdecia, Marlene, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Marin-Prida, Javier, González-Durruthy, Michael, Uyemura, Sergio A., Rodrigues, Fernando P., Curti, Carlos, Souza, Diogo O., Pardo-Andreu, Gilberto L.
Published in European journal of pharmacology (05.03.2014)
Published in European journal of pharmacology (05.03.2014)
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Journal Article
The effects of JM-20 on the glutamatergic system in synaptic vesicles, synaptosomes and neural cells cultured from rat brain
Nuñez-Figueredo, Yanier, Pardo Andreu, Gilberto L., Oliveira Loureiro, Samanta, Ganzella, Marcelo, Ramírez-Sánchez, Jeney, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Souza, Diogo O.
Published in Neurochemistry international (01.02.2015)
Published in Neurochemistry international (01.02.2015)
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