Calcium-independent Phospholipase A2 (iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis
Lei, Xiaoyong, Zhang, Sheng, Bohrer, Alan, Ramanadham, Sasanka
Published in The Journal of biological chemistry (12.12.2008)
Published in The Journal of biological chemistry (12.12.2008)
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Journal Article
Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes
Ali, Tomader, Lei, Xiaoyong, Barbour, Suzanne E., Koizumi, Akio, Chalfant, Charles E., Ramanadham, Sasanka
Published in Molecules (Basel, Switzerland) (21.10.2021)
Published in Molecules (Basel, Switzerland) (21.10.2021)
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Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells
Turk, John, Song, Haowei, Wohltmann, Mary, Frankfater, Cheryl, Lei, Xiaoyong, Ramanadham, Sasanka
Published in Biomolecules (Basel, Switzerland) (17.10.2020)
Published in Biomolecules (Basel, Switzerland) (17.10.2020)
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Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling
Aguirre, Rebecca S., Kulkarni, Abhishek, Becker, Matthew W., Lei, Xiaoyong, Sarkar, Soumyadeep, Ramanadham, Sasanka, Phelps, Edward A., Nakayasu, Ernesto S., Sims, Emily K., Mirmira, Raghavendra G.
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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Journal Article
The Impact of the Ca2+-Independent Phospholipase A2β (iPLA2β) on Immune Cells
White, Tayleur D., Almutairi, Abdulaziz, Tusing, Ying Gai, Lei, Xiaoyong, Ramanadham, Sasanka
Published in Biomolecules (Basel, Switzerland) (15.04.2021)
Published in Biomolecules (Basel, Switzerland) (15.04.2021)
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Journal Article
The Group VIA Calcium-Independent Phospholipase A2 Participates in ER Stress-Induced INS-1 Insulinoma Cell Apoptosis by Promoting Ceramide Generation via Hydrolysis of Sphingomyelins by Neutral Sphingomyelinase
Lei, Xiaoyong, Zhang, Sheng, Bohrer, Alan, Bao, Shunzhong, Song, Haowei, Ramanadham, Sasanka
Published in Biochemistry (Easton) (04.09.2007)
Published in Biochemistry (Easton) (04.09.2007)
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Journal Article
Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice[S]
Nelson, Alexander J., Stephenson, Daniel J., Cardona, Christopher L., Lei, Xiaoyong, Almutairi, Abdulaziz, White, Tayleur D., Tusing, Ying G., Park, Margaret A., Barbour, Suzanne E., Chalfant, Charles E., Ramanadham, Sasanka
Published in Journal of lipid research (01.02.2020)
Published in Journal of lipid research (01.02.2020)
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Journal Article
Male Mice That Do Not Express Group VIA Phospholipase A2 Produce Spermatozoa with Impaired Motility and Have Greatly Reduced Fertility
Bao, Shunzhong, Miller, David J., Ma, Zhongmin, Wohltmann, Mary, Eng, Grace, Ramanadham, Sasanka, Moley, Kelle, Turk, John
Published in The Journal of biological chemistry (10.09.2004)
Published in The Journal of biological chemistry (10.09.2004)
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A proteomic meta-analysis refinement of plasma extracellular vesicles
Vallejo, Milene C, Sarkar, Soumyadeep, Elliott, Emily C, Henry, Hayden R, Powell, Samantha M, Diaz Ludovico, Ivo, You, Youngki, Huang, Fei, Payne, Samuel H, Ramanadham, Sasanka, Sims, Emily K, Metz, Thomas O, Mirmira, Raghavendra G, Nakayasu, Ernesto S
Published in Scientific data (28.11.2023)
Published in Scientific data (28.11.2023)
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Journal Article
Insulin Secretory Responses and Phospholipid Composition of Pancreatic Islets from Mice That Do Not Express Group VIA Phospholipase A2 and Effects of Metabolic Stress on Glucose Homeostasis
Bao, Shunzhong, Song, Haowei, Wohltmann, Mary, Ramanadham, Sasanka, Jin, Wu, Bohrer, Alan, Turk, John
Published in The Journal of biological chemistry (28.07.2006)
Published in The Journal of biological chemistry (28.07.2006)
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Journal Article
Loss of Brain Angiogenesis Inhibitor-3 (BAI3) G-Protein Coupled Receptor in Mice Regulates Adaptive Thermogenesis by Enhancing Energy Expenditure
Alsharif, Haifa, Latimer, Mary N, Perez, Katherine C, Alexander, Justin, Rahman, Md Mostafizur, Challa, Anil K, Kim, Jeong-A, Ramanadham, Sasanka, Young, Martin, Bhatnagar, Sushant
Published in Metabolites (31.05.2023)
Published in Metabolites (31.05.2023)
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Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling
Hawkins, Cyntanna C, Jones, Amber B, Gordon, Emily R, Williford, Sarah E, Harsh, Yuvika, Ziebro, Julia K, Landis, Catherine J, Gc, Sajina, Crossman, David K, Cooper, Sara J, Ramanadham, Sasanka, Doan, Ninh, Hjelmeland, Anita B
Published in Cells (Basel, Switzerland) (09.06.2022)
Published in Cells (Basel, Switzerland) (09.06.2022)
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Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells
Hawkins, Cyntanna C, Jones, Amber B, Gordon, Emily R, Harsh, Yuvika, Ziebro, Julia K, Willey, Christopher D, Griguer, Corinne, Crossman, David K, Cooper, Sara J, Ramanadham, Sasanka, Doan, Ninh, Hjelmeland, Anita B
Published in Cell death discovery (12.12.2023)
Published in Cell death discovery (12.12.2023)
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Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus
Shao, Chun Hong, Tian, Chengju, Ouyang, Shouqiang, Moore, Caronda J, Alomar, Fadhel, Nemet, Ina, D'Souza, Alicia, Nagai, Ryoji, Kutty, Shelby, Rozanski, George J, Ramanadham, Sasanka, Singh, Jaipaul, Bidasee, Keshore R
Published in Molecular pharmacology (01.09.2012)
Published in Molecular pharmacology (01.09.2012)
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Journal Article
Lipid mediators and biomarkers associated with type 1 diabetes development
Nelson, Alexander J, Stephenson, Daniel J, Bone, Robert N, Cardona, Christopher L, Park, Margaret A, Tusing, Ying G, Lei, Xiaoyong, Kokotos, George, Graves, Christina L, Mathews, Clayton E, Kramer, Joanna, Hessner, Martin J, Chalfant, Charles E, Ramanadham, Sasanka
Published in JCI insight (20.08.2020)
Published in JCI insight (20.08.2020)
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Journal Article
Effects of Stable Suppression of Group VIA Phospholipase A2 Expression on Phospholipid Content and Composition, Insulin Secretion, and Proliferation of INS-1 Insulinoma Cells
Bao, Shunzhong, Bohrer, Alan, Ramanadham, Sasanka, Jin, Wu, Zhang, Sheng, Turk, John
Published in The Journal of biological chemistry (06.01.2006)
Published in The Journal of biological chemistry (06.01.2006)
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Journal Article
Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2
Bao, Shunzhong, Li, Yankun, Lei, Xiaoyong, Wohltmann, Mary, Jin, Wu, Bohrer, Alan, Semenkovich, Clay F., Ramanadham, Sasanka, Tabas, Ira, Turk, John
Published in The Journal of biological chemistry (14.09.2007)
Published in The Journal of biological chemistry (14.09.2007)
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Journal Article
Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes
Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N, Mobley, James A, Hancock, William, Ramanadham, Sasanka
Published in PloS one (2013)
Published in PloS one (2013)
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