Increased classical endoplasmic reticulum stress is sufficient to reduce chondrocyte proliferation rate in the growth plate and decrease bone growth
Kung, Louise H W, Rajpar, M Helen, Preziosi, Richard, Briggs, Michael D, Boot-Handford, Raymond P
Published in PloS one (18.02.2015)
Published in PloS one (18.02.2015)
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Targeted induction of endoplasmic reticulum stress induces cartilage pathology
Rajpar, M Helen, McDermott, Ben, Kung, Louise, Eardley, Rachel, Knowles, Lynette, Heeran, Mel, Thornton, David J, Wilson, Richard, Bateman, John F, Poulsom, Richard, Arvan, Peter, Kadler, Karl E, Briggs, Michael D, Boot-Handford, Raymond P
Published in PLoS genetics (01.10.2009)
Published in PLoS genetics (01.10.2009)
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Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy
Cameron, Trevor L, Bell, Katrina M, Tatarczuch, Liliana, Mackie, Eleanor J, Rajpar, M Helen, McDermott, Ben T, Boot-Handford, Raymond P, Bateman, John F
Published in PloS one (15.09.2011)
Published in PloS one (15.09.2011)
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An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia
Nundlall, Seema, Rajpar, M. Helen, Bell, Peter A., Clowes, Christopher, Zeeff, Leo A. H., Gardner, Benjamin, Thornton, David J., Boot-Handford, Raymond P., Briggs, Michael D.
Published in Cell stress & chaperones (01.11.2010)
Published in Cell stress & chaperones (01.11.2010)
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A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth
Gualeni, Benedetta, Rajpar, M Helen, Kellogg, Aaron, Bell, Peter A, Arvan, Peter, Boot-Handford, Raymond P, Briggs, Michael D
Published in Disease models & mechanisms (01.11.2013)
Published in Disease models & mechanisms (01.11.2013)
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Hypertrophic Chondrocytes Have a Limited Capacity to Cope with Increases in Endoplasmic Reticulum Stress without Triggering the Unfolded Protein Response
Kung, Louise H. W., Rajpar, M. Helen, Briggs, Michael D., Boot-Handford, Raymond P.
Published in The journal of histochemistry and cytochemistry (01.10.2012)
Published in The journal of histochemistry and cytochemistry (01.10.2012)
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Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization
Rajpar, M. Helen, Koch, Martin J., Davies, Robin M., Mellody, Kieran T., Kielty, Cay M., Dixon, Michael J.
Published in Human molecular genetics (01.10.2002)
Published in Human molecular genetics (01.10.2002)
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Germline E-cadherin Gene (CDH1) Mutations Predispose to Familial Gastric Cancer and Colorectal Cancer
Richards, Frances M., McKee, Shane A., Rajpar, M. Helen, Cole, Trevor R. P., Evans, D. Gareth R., Jankowski, Janusz A., McKeown, Carole, Sanders, D. Scott A., Maher, Eamonn R.
Published in Human molecular genetics (01.04.1999)
Published in Human molecular genetics (01.04.1999)
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Journal Article
Targeted induction of endoplasmic reticulum stress induces cartilage pathology
Rajpar, M. Helen, McDermott, Ben, Kung, Louise, Eardley, Rachel, Knowles, Lynette, Heeran, Mel, Thornton, David J, Wilson, Richard, Bateman, John F, Poulsom, Richard, Arvan, Peter, Kadler, Karl E, Briggs, Michael D, Boot-Handford, Raymond P
Published in PLoS genetics (01.10.2009)
Published in PLoS genetics (01.10.2009)
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Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology: e1000691
Rajpar, M Helen, McDermott, Ben, Kung, Louise, Eardley, Rachel, Knowles, Lynette, Heeran, Mel, Thornton, David J, Wilson, Richard, Bateman, John F, Poulsom, Richard, Arvan, Peter, Kadler, Karl E, Briggs, Michael D, Boot-Handford, Raymond P
Published in PLoS genetics (01.10.2009)
Published in PLoS genetics (01.10.2009)
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Germline mutation analysis of the transforming growth factor [beta] receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer
VERMA, LOVEENA, PORTER, TIMOTHY R, RICHARDS, FRANCES M, RAJPAR, M HELEN, EVANS, D GARETH R, MACDONALD, FIONA, MAHER, EAMONN R
Published in Journal of medical genetics (01.02.2001)
Published in Journal of medical genetics (01.02.2001)
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Type I collagen C-propeptide cleavage deficiency increases bone mineralization and alters bone cell differentiation
Barnes, Aileen, Perosky, Joseph, Blouin, Stephane, Rajpar, M. Helen, Khoury, Basma, Weis, MaryAnn, Klaushofer, Klaus, Roschger, Paul, Eyre, David, Fratzl-Zelman, Nadja, Kozloff, Kenneth, Marini, Joan
Published in Bone Abstracts (11.07.2017)
Published in Bone Abstracts (11.07.2017)
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Bone with uncleavable type I collagen C-propeptide has abnormal development of multiple bone cell populations and increased bone mineral density with age
Barnes, Aileen M, Perosky, Joseph E, Blouin, Stephane, Rajpar, M Helen, Khoury, Basma, Klaushofer, Klaus, Roschger, Paul, Fratzl-Zelman, Nadja, Kozloff, Kenneth M, Marini, Joan C
Published in Bone Abstracts (21.04.2016)
Published in Bone Abstracts (21.04.2016)
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Germline mutation analysis of the transforming growth factor β receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer
VERMA, LOVEENA, PORTER, TIMOTHY R, RICHARDS, FRANCES M, RAJPAR, M HELEN, EVANS, D GARETH R, MACDONALD, FIONA, MAHER, EAMONN R
Published in Journal of medical genetics (01.02.2001)
Published in Journal of medical genetics (01.02.2001)
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