African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development
Rajman, Iris, Knapp, Laura, Morgan, Thomas, Masimirembwa, Collen
Published in EBioMedicine (01.03.2017)
Published in EBioMedicine (01.03.2017)
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Journal Article
Genetic Diversity in Drug Transporters: Impact in African Populations
Rajman, Iris, Knapp, Laura, Hanna, Imad
Published in Clinical and translational science (01.09.2020)
Published in Clinical and translational science (01.09.2020)
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Journal Article
Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor
Ayalasomayajula, Surya P., Langenickel, Thomas H., Jordaan, Pierre, Zhou, Wei, Chandra, Priyamvada, Albrecht, Diego, Pal, Parasar, Rajman, Iris, Sunkara, Gangadhar
Published in European journal of clinical pharmacology (01.09.2016)
Published in European journal of clinical pharmacology (01.09.2016)
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Journal Article
Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populations
Dahlke, Marion, Ng, Dik, Yamaguchi, Masayuki, Machineni, Surendra, Berger, Sergej, Canadi, Jasna, Rajman, Iris, Lloyd, Peter, Pang, Yinuo
Published in Journal of clinical pharmacology (01.04.2015)
Published in Journal of clinical pharmacology (01.04.2015)
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Journal Article
New paradigm for expediting drug development in Asia
Rajman, Iris, Hirano, Masaru, Honma, Wataru, Zhao, Sylvia
Published in Drug discovery today (01.03.2020)
Published in Drug discovery today (01.03.2020)
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Journal Article
The effect of LCZ696 (sacubitril/valsartan) on amyloid‐β concentrations in cerebrospinal fluid in healthy subjects
Langenickel, Thomas H., Tsubouchi, Chiaki, Ayalasomayajula, Surya, Pal, Parasar, Valentin, Marie‐Anne, Hinder, Markus, Jhee, Stanford, Gevorkyan, Hakop, Rajman, Iris
Published in British journal of clinical pharmacology (01.05.2016)
Published in British journal of clinical pharmacology (01.05.2016)
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Journal Article
Effects of age and sex on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor
Gan, Lu, Langenickel, Thomas, Petruck, Jesika, Kode, Kiran, Rajman, Iris, Chandra, Priya, Zhou, Wei, Rebello, Sam, Sunkara, Gangadhar
Published in Journal of clinical pharmacology (01.01.2016)
Published in Journal of clinical pharmacology (01.01.2016)
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Journal Article
Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization
Langenickel, Thomas H., Jordaan, Pierre, Petruck, Jesika, Kode, Kiran, Pal, Parasar, Vaidya, Soniya, Chandra, Priya, Rajman, Iris
Published in European journal of clinical pharmacology (01.08.2016)
Published in European journal of clinical pharmacology (01.08.2016)
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Journal Article
Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction
Kobalava, Zhanna, Kotovskaya, Yulia, Averkov, Oleg, Pavlikova, Elena, Moiseev, Valentine, Albrecht, Diego, Chandra, Priya, Ayalasomayajula, Surya, Prescott, Margaret F., Pal, Parasar, Langenickel, Thomas H., Jordaan, Pierre, Rajman, Iris
Published in Cardiovascular therapeutics (01.08.2016)
Published in Cardiovascular therapeutics (01.08.2016)
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Journal Article
Pharmacokinetics of serelaxin in patients with hepatic impairment: a single‐dose, open‐label, parallel group study
Kobalava, Zhanna, Villevalde, Svetlana, Kotovskaya, Yulia, Hinrichsen, Holger, Petersen‐Sylla, Marc, Zaehringer, Andreas, Pang, Yinuo, Rajman, Iris, Canadi, Jasna, Dahlke, Marion, Lloyd, Peter, Halabi, Atef
Published in British journal of clinical pharmacology (01.06.2015)
Published in British journal of clinical pharmacology (01.06.2015)
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Journal Article
Assessment of Drug–Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects
Ayalasomayajula, Surya, Pan, Wei, Han, Yi, Yang, Fan, Langenickel, Thomas, Pal, Parasar, Zhou, Wei, Yuan, Yaozong, Rajman, Iris, Sunkara, Gangadhar
Published in European journal of drug metabolism and pharmacokinetics (01.04.2017)
Published in European journal of drug metabolism and pharmacokinetics (01.04.2017)
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Journal Article
Pharmacokinetics and safety of sacubitril/valsartan (LCZ696) in patients with mild and moderate hepatic impairment
Kulmatycki, Kenneth M, Langenickel, Thomas, Ng, Wai Hong, Pal, Parasar, Zhou, Wei, Lin, Tsu-Han, Rajman, Iris, Chandra, Priyamvada, Sunkara, Gangadhar
Published in International journal of clinical pharmacology and therapeutics (01.09.2017)
Published in International journal of clinical pharmacology and therapeutics (01.09.2017)
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Journal Article
Effect of food on the oral bioavailability of the angiotensin receptor - neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects
Ayalasomayajula, Surya, Langenickel, Thomas H, Chandra, Priya, Wolfson, Edward D, Albrecht, Diego, Zhou, Wei, Pal, Parasar, Rajman, Iris, Sunkara, Gangadhar
Published in International journal of clinical pharmacology and therapeutics (01.12.2016)
Published in International journal of clinical pharmacology and therapeutics (01.12.2016)
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Journal Article
Pharmacokinetic drug-drug interaction assessment between LCZ696, an angiotensin receptor neprilysin inhibitor, and hydrochlorothiazide, amlodipine, or carvedilol
Hsiao, Hsiu-ling, Langenickel, Thomas Heiko, Greeley, Michael, Roberts, John, Zhou, Wei, Pal, Parasar, Rebello, Sam, Rajman, Iris, Sunkara, Gangadhar
Published in Clinical pharmacology in drug development (01.11.2015)
Published in Clinical pharmacology in drug development (01.11.2015)
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Journal Article
Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects
Gan, Lu, Jiang, Xuemin, Mendonza, Anisha, Swan, Therese, Reynolds, Christine, Nguyen, Joanne, Pal, Parasar, Neelakantham, Srikanth, Dahlke, Marion, Langenickel, Thomas, Rajman, Iris, Akahori, Mizuki, Zhou, Wei, Rebello, Sam, Sunkara, Gangadhar
Published in Clinical pharmacology in drug development (01.01.2016)
Published in Clinical pharmacology in drug development (01.01.2016)
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Cytochrome P450 2C192 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care
Rothenbacher, Dietrich, Hoffmann, Michael M, Breitling, Lutz P, Rajman, Iris, Koenig, Wolfgang, Brenner, Hermann
Published in BMC cardiovascular disorders (27.08.2013)
Published in BMC cardiovascular disorders (27.08.2013)
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