Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa
Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Discovery of novel heterocyclic factor VIIa inhibitors
Rai, Roopa, Kolesnikov, Aleksandr, Sprengeler, Paul A., Torkelson, Steven, Ton, Tony, Katz, Bradley A., Yu, Christine, Hendrix, John, Shrader, William D., Stephens, Robin, Cabuslay, Ronnell, Sanford, Ellen, Young, Wendy B.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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Journal Article
Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model
Young, Wendy B., Mordenti, Joyce, Torkelson, Steven, Shrader, William D., Kolesnikov, Aleksandr, Rai, Roopa, Liu, Liang, Hu, Huiyong, Leahy, Ellen M., Green, Michael J., Sprengeler, Paul A., Katz, Bradley A., Yu, Christine, Janc, James W., Elrod, Kyle C., Marzec, Ulla M., Hanson, Stephen R.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Discovery of MDV6058 (PF-06952229), a selective and potent TGF?R1 inhibitor: Design, synthesis and optimization
Pujala, Brahmam, Ramachandran, Sreekanth A., Sonawane, Mukesh, Kamble, Maruti M., Panpatil, Dayanand, Adhikari, Swati, Soni, Sanjeev, Subbareddy, Venkata, Shinde, Bharat U., Nayak, Anjan K., Bansal, Chandni, Gupta, Ashu, Mukherjee, Kakoli, Agarwal, Anil K., Guerrero, Javier, Herrera, Francisco J., Bernales, Sebastian, Guha, Mausumee, Chakravarty, Sarvajit, Pham, Son M., Rai, Roopa
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
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Journal Article
PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells
Huang, Qi, Haydar, Simon, Zhou, Yi, Cai, Dawei, Xu, Xiang, Yan, Ran, Guo, Lida, Carabajal, Esteban, Tang, Xuman, Walker, Michael, Rai, Roopa, Bures, Mark, Li, Leping, Colonno, Richard
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Discovery of MDV6058 (PF-06952229), a selective and potent TGFβR1 inhibitor: Design, synthesis and optimization
Pujala, Brahmam, Ramachandran, Sreekanth A., Sonawane, Mukesh, Kamble, Maruti M., Panpatil, Dayanand, Adhikari, Swati, Soni, Sanjeev, Subbareddy, Venkata, Shinde, Bharat U., Nayak, Anjan K., Bansal, Chandni, Gupta, Ashu, Mukherjee, Kakoli, Agarwal, Anil K., Guerrero, Javier, Herrera, Francisco J., Bernales, Sebastian, Guha, Mausumee, Chakravarty, Sarvajit, Pham, Son M., Rai, Roopa
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
Published in Bioorganic & medicinal chemistry letters (01.11.2022)
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Journal Article
Abstract PO3-26-04: Discovery of novel inhibitors of the epigenetic regulatory KAT6A histone acetyl transferase and their anti-tumor activity in breast cancer cells
Holsinger, Leslie, RaI, Roopa, Nagawade, Rahul R., Pal, Benoy, Pawar, Samir, Singh, Pankaj, Putta, Krishna, Jaleel, Mahaboobi, Bostrom, Tove, Karen, Jakob, Huang, Qianyang, Hannah, Alison
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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Journal Article
Abstract 3217: Discovery of novel inhibitors of the epigenetic regulator Kat6a histone acetyl transferase and characterization of their anti-tumor activity
Holsinger, Leslie J., Rai, Roopa, Nagawade, Rahul R., Pal, Benoy K., Pawar, Samir G., Putta, Krishna Anand, S.C., Somashekar, Jaleel, Mahaboobi, Wang, Jianhong, Hannah, Alison L.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors
Ramachandran, Sreekanth A., Jadhavar, Pradeep S., Miglani, Sandeep K., Singh, Manvendra P., Kalane, Deepak P., Agarwal, Anil K., Sathe, Balaji D., Mukherjee, Kakoli, Gupta, Ashu, Haldar, Srijan, Raja, Mohd, Singh, Siddhartha, Pham, Son M., Chakravarty, Sarvajit, Quinn, Kevin, Belmar, Sebastian, Alfaro, Ivan E., Higgs, Christopher, Bernales, Sebastian, Herrera, Francisco J., Rai, Roopa
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Abstract B30: Talazoparib efficacy is enhanced by noncytotoxic doses of temozolomide-mediated DNA damage in prostate cancer cell lines
Lindquist, Jeffrey N., Phan, Vernon T., Riquelme, Eduardo, Mukherjee, Kakoli, Farías, Olivia, Gupta, Ashu, Raja, Mohd, Rai, Roopa, Uppal, Hirdesh, Protter, Andrew A.
Published in Molecular cancer research (01.04.2017)
Published in Molecular cancer research (01.04.2017)
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HBV의 치료를 위한 5원 헤테로아릴 카르복스아미드 화합물
BANNEN LYNNE, LI LEPING, BURES MARK G, WALKER MICHAEL, HAYDAR SIMON NICOLAS, RAI ROOPA
Year of Publication 30.07.2021
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Year of Publication 30.07.2021
Patent
Temozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide
Rai, Roopa, Banerjee, Monali, Wong, Darren H., McCullagh, Emma, Gupta, Ashu, Tripathi, Shailendra, Riquelme, Eduardo, Jangir, Ramnivas, Yadav, Shyamraj, Raja, Mohd, Melkani, Pankaj, Dixit, Vikas, Patil, Umesh, Shrivastava, Ritesh, Middya, Sandip, Olivares, Felipe, Guerrero, Javier, Surya, Arjun, Pham, Son M., Bernales, Sebastián, Protter, Andrew A., Hung, David T., Chakravarty, Sarvajit
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors
Jadhavar, Pradeep S., Ramachandran, Sreekanth A., Riquelme, Eduardo, Gupta, Ashu, Quinn, Kevin P., Shivakumar, Devleena, Ray, Soumya, Zende, Dnyaneshwar, Nayak, Anjan K., Miglani, Sandeep K., Sathe, Balaji D., Raja, Mohd, Farias, Olivia, Alfaro, Ivan, Belmar, Sebastián, Guerrero, Javier, Bernales, Sebastián, Chakravarty, Sarvajit, Hung, David T., Lindquist, Jeffrey N., Rai, Roopa
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR
Ansari, Amantullah, Satalkar, Sharad, Patil, Varshavekumar, Shete, Amit S., Kaur, Simranjeet, Gupta, Ashu, Singh, Siddhartha, Raja, Mohd, Severance, Daniel L., Bernales, Sebastián, Chakravarty, Sarvajit, Hung, David T., Pham, Son M., Herrera, Francisco J., Rai, Roopa
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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