Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
Dror, Ron O, Green, Hillary F, Valant, Celine, Borhani, David W, Valcourt, James R, Pan, Albert C, Arlow, Daniel H, Canals, Meritxell, Lane, J Robert, Rahmani, Raphaël, Baell, Jonathan B, Sexton, Patrick M, Christopoulos, Arthur, Shaw, David E
Published in Nature (London) (14.11.2013)
Published in Nature (London) (14.11.2013)
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Crystal structure of the M₅ muscarinic acetylcholine receptor
Vuckovic, Ziva, Gentry, Patrick R., Berizzi, Alice E., Hirata, Kunio, Varghese, Swapna, Thompson, Geoff, van der Westhuizen, Emma T., Burger, Wessel A. C., Rahmani, Raphaël, Valant, Celine, Langmead, Christopher J., Lindsley, Craig W., Baell, Jonathan B., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur, Thal, David M.
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
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Journal Article
8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Dennis, Matthew L., Lee, Michael D., Harjani, Jitendra R., Ahmed, Mohamed, DeBono, Aaron J., Pitcher, Noel P., Wang, Zhong‐Chang, Chhabra, Sandeep, Barlow, Nicholas, Rahmani, Raphaël, Cleary, Ben, Dolezal, Olan, Hattarki, Meghan, Aurelio, Luigi, Shonberg, Jeremy, Graham, Bim, Peat, Thomas S., Baell, Jonathan B., Swarbrick, James D.
Published in Chemistry : a European journal (06.02.2018)
Published in Chemistry : a European journal (06.02.2018)
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Journal Article
Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei
Ferrins, Lori, Gazdik, Michelle, Rahmani, Raphaël, Varghese, Swapna, Sykes, Melissa L, Jones, Amy J, Avery, Vicky M, White, Karen L, Ryan, Eileen, Charman, Susan A, Kaiser, Marcel, Bergström, Christel A. S, Baell, Jonathan B
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Discovery of Potent N‑Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi
Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M, Piggott, Matthew J, Baell, Jonathan B
Published in ACS medicinal chemistry letters (12.03.2020)
Published in ACS medicinal chemistry letters (12.03.2020)
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Journal Article
Drug discovery and human African trypanosomiasis: a disease less neglected?
Ferrins, Lori, Rahmani, Raphaël, Baell, Jonathan B
Published in Future medicinal chemistry (01.10.2013)
Published in Future medicinal chemistry (01.10.2013)
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Journal Article
6‑Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors
Rahmani, Raphaël, Ban, Kung, Jones, Amy J., Ferrins, Lori, Ganame, Danny, Sykes, Melissa L., Avery, Vicky M., White, Karen L., Ryan, Eileen, Kaiser, Marcel, Charman, Susan A., Baell, Jonathan B.
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion
Johnson, Swapna, Rahmani, Raphaël, Drew, Damien R, Williams, Melanie J, Wilkinson, Mark, Tan, Yan Hong, Huang, Johnny X, Tonkin, Christopher J, Beeson, James G, Baum, Jake, Smith, Brian J, Baell, Jonathan B
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
Structural Basis for the Selective Binding of Inhibitors to 6‑Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli
Dennis, Matthew L, Pitcher, Noel P, Lee, Michael D, DeBono, Aaron J, Wang, Zhong-Chang, Harjani, Jitendra R, Rahmani, Raphaël, Cleary, Ben, Peat, Thomas S, Baell, Jonathan B, Swarbrick, James D
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Journal Article
Structure‐Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity
Varghese, Swapna, Rahmani, Raphaël, Drew, Damien R., Beeson, James G., Baum, Jake, Smith, Brian J., Baell, Jonathan B.
Published in ChemMedChem (17.02.2021)
Published in ChemMedChem (17.02.2021)
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Journal Article
Copper‐Catalyzed Preparation of γ‐Alkylidenebutenolides and Isocoumarins under Mild Palladium‐Free Conditions
Inack‐Ngi, Samuel, Rahmani, Raphaël, Commeiras, Laurent, Chouraqui, Gaëlle, Thibonnet, Jérôme, Duchêne, Alain, Abarbri, Mohamed, Parrain, Jean‐Luc
Published in Advanced synthesis & catalysis (01.03.2009)
Published in Advanced synthesis & catalysis (01.03.2009)
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Journal Article
trans-1,2-Disiloxybenzocyclobutene, an adequate partner for the auto-oxidation: EPR/spin trapping and theoretical studies
Drujon, Jean, Rahmani, Raphaël, Héran, Virginie, Blanc, Romain, Carissan, Yannick, Tuccio, Béatrice, Commeiras, Laurent, Parrain, Jean-Luc
Published in Physical chemistry chemical physics : PCCP (01.01.2014)
Published in Physical chemistry chemical physics : PCCP (01.01.2014)
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Journal Article
Dramatic influence of the substitution of alkylidene-5H-furan-2-ones in Diels-Alder cycloadditions with o-quinonedimethide as diene partner: en route to the CDEF polycyclic ring system of lactonamycin
Dubois, Sebastien, Rodier, Fabien, Blanc, Romain, Rahmani, Raphael, Heran, Virginie, Thibonnet, Jerome, Commeiras, Laurent, Parrain, Jean-Luc
Published in Organic & biomolecular chemistry (28.06.2012)
Published in Organic & biomolecular chemistry (28.06.2012)
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Journal Article
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis
Ferrins, Lori, Rahmani, Raphaël, Sykes, Melissa L., Jones, Amy J., Avery, Vicky M., Teston, Eliott, Almohaywi, Basmah, Yin, JieXiang, Smith, Jason, Hyland, Chris, White, Karen L., Ryan, Eileen, Campbell, Michael, Charman, Susan A., Kaiser, Marcel, Baell, Jonathan B.
Published in European journal of medicinal chemistry (01.08.2013)
Published in European journal of medicinal chemistry (01.08.2013)
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Journal Article
Diels-Alder cycloaddition of o-quinonedimethides and alkylidene-5H-furan-2-ones: new and rapid access to lambertellol cores and arthrinone derivatives
Blanc, Romain, Heran, Virginie, Rahmani, Raphael, Commeiras, Laurent, Parrain, Jean-Luc
Published in Organic & biomolecular chemistry (21.12.2010)
Published in Organic & biomolecular chemistry (21.12.2010)
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Journal Article
Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism
Varghese, Swapna, Srivastava, Anubhav, Wong, Siu Wai, Le, Thuy, Pitcher, Noel, Mesnard, Mathilda, Lallemand, Camille, Rahmani, Raphael, Moawad, Sarah R., Huang, Fei, He, Tiantong, Sleebs, Brad E., Barrett, Michael P., Sykes, Melissa L., Avery, Vicky M., Creek, Darren J., Baell, Jonathan B.
Published in European journal of medicinal chemistry (15.03.2024)
Published in European journal of medicinal chemistry (15.03.2024)
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Journal Article
Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides
McNamara, Nicole, Rahmani, Raphael, Sykes, Melissa L, Avery, Vicky M, Baell, Jonathan
Published in MedChemComm (01.06.2020)
Published in MedChemComm (01.06.2020)
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Journal Article
Abstract B119: First-in-class orally active pharmacological inhibitors of TRPV6 for the treatment of advanced prostate cancer
Monteith, Gregory, Beaumont, Kimberley, Pouwer, Rebecca, Farrow, Rebecca, McLachlan, Matthew, Yeh, Mei, Johnson, Therese, Rahmani, Raphael, Levrier, Claire, Wijesekera, Hasanthi, Kumarasiri, Malika, Stuchbury, Grant, Cock, Terrie-Anne, Harvey, Andrew, Dymock, Brian
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0md00058b
McNamara, Nicole, Rahmani, Raphael, Sykes, Melissa L., Avery, Vicky M., Baell, Jonathan
Published in RSC medicinal chemistry (29.05.2020)
Published in RSC medicinal chemistry (29.05.2020)
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Journal Article
Abstract PR010: First-in-class TRPV6 inhibitors for the treatment of prostate cancer
Beaumont, Kimberley, Pouwer, Rebecca, Rahmani, Raphael, McLachlan, Matthew, Levrier, Claire, Farrow, Rebecca, Yeh, Mei, Johnson, Therese, Kumarasiri, Malika, Wijesekera, Hasanthi, Stuchbury, Grant, Cock, Terrie-Anne, Harvey, Andrew, Monteith, Gregory, Dymock, Brian
Published in Cancer research (Chicago, Ill.) (02.06.2023)
Published in Cancer research (Chicago, Ill.) (02.06.2023)
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