Development of a Commercial Process for Odalasvir
Tran, Duc N, Zhdanko, Alexander, Barroso, Santiago, Nieste, Patrick, Rahmani, Ramdane, Holan, Jan, Hoefnagels, Roel, Reniers, Peter, Vermoortele, Frederik, Duguid, Stewart, Cazanave, Lionel, Figlus, Marek, Muir, Colin, Elliott, Alain, Zhao, Peichao, Paden, Warren, Diaz, Cristina Hernandez, Bell, Stephen J, Hashimoto, Akihiro, Phadke, Avinash, Wiles, Jason A, Vogels, Ilse, Farina, Vittorio
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
(6R,10S)-10-{4-[5-클로로-2-(4-클로로-1H-1,2,3-트리아졸-1-일)페닐]-6-옥소-1(6H)-피리미디닐}-1-피라졸로[4,3-B][1,7]디아자시클로테트라데신-5(6H)-온을 제조하는 방법
SKLIAR DIMITRI, JUSSEAU XAVIER JEAN MARIE, LUO HELEN Y, PEREGO LUCA ALESSANDRO, BROGGINI DIEGO FERNANDO DOMENICO, XIOURAS CHRISTOS, RAHMANI RAMDANE, EASTGATE MARTIN D, CHERNICHENKO KOSTIANTYN, MUKHERJEE SUBHA, JAMISON CHRISTOPHER ROBERT, SFOUGGATAKIS CHRIS, WAGSCHAL SIMON ALBERT, GALLAGHER WILLIAM P, KOLOTUCHIN SERGEI, LEMAIRE SEBASTIEN FRANCOIS EMMANUEL, MATCHA KIRAN, WEI CAROLYN S, CAO DUY CHI TRUNG, REUTER KARL, ZHDANKO ALEXANDER, TRAN NGOC DUC, CUNIERE NICOLAS, SINGH AMARJIT, MOWER MATTHEW PENFIELD, WISNIEWSKI STEVEN R, KOSCHKER PHILIPP, ZHENG BIN, ORTIZ ADRIAN, BEN HAIM CYRIL, SCHMALZBAUER BJOERN
Year of Publication 13.07.2023
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Year of Publication 13.07.2023
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 06.06.2024
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Year of Publication 06.06.2024
Patent
PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 28.12.2023
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Year of Publication 28.12.2023
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 16.08.2023
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Year of Publication 16.08.2023
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 08.06.2023
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Year of Publication 08.06.2023
Patent
A process toward the manufacture of (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b] [1,7]diazacyclotetradecin-5(6h)-one
WAGSCHAL Simon Albert, CAO Duy Chi Trung, MOWER Matthew Penfield, PEREGO Luca Alessandro, BROGGINI Diego Fernando Domenico, GALLAGHER William P, WEI Carolyn S, SCHMALZBAUER Bj?rn, KOSCHKER Philipp, ZHDANKO Alexander, WISNIEWSKI Steven R, MUKHERJEE Subha, SINGH Amarjit, CHERNICHENKO Kostiantyn, TRAN Ngoc Duc, XIOURAS Christos, ORTIZ Adrian, CUNIERE Nicolas, ZHENG Bin, JAMISON Christopher Robert, SKLIAR Dimitri, EASTGATE Martin D, KOLOTUCHIN Sergei, MATCHA Kiran, LUO Helen Y, SFOUGGATAKIS Chris, LEMAIRE S?bastien Fran?ois Emmanuel, JUSSEAU Xavier Jean-Marie, BEN HA?M Cyril, REUTER Karl, RAHMANI Ramdane
Year of Publication 01.06.2023
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Year of Publication 01.06.2023
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Year of Publication 21.04.2022
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Year of Publication 21.04.2022
Patent
A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, MATCHA, KIRAN, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG
Year of Publication 21.04.2022
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Year of Publication 21.04.2022
Patent
PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA
NICOLAS CUNIERE, NGOC DUC TRAN, XAVIER JEAN-MARIE JUSSEAU, HELEN Y. LUO, RAMDANE RAHMANI, SÉBASTIEN FRANÇOIS EMMANUEL LEMAIRE, CHRISTOPHER ROBERT JAMISON, CYRIL BEN HAIM, SIMON ALBERT WAGSCHAL, CAROLYN S. WEI, BJÖRN SCHMALZBAUER, AMARJIT SINGH, LUCA ALESSANDRO PEREGO, SUBHA MUKHERJEE, DIEGO FERNANDO DOMENICO BROGGINI, CHRIS SFOUGGATAKIS, BIN ZHENG, DUY CHI TRUNG CAO, PHILIPP KOSCHKER, WILLIAM P. GALLAGHER, KOSTIANTYN CHERNICHENKO, SERGEI KOLOTUCHIN, DIMITRI SKLIAR, STEVEN R. WISNIEWSKI, MARTIN D. EASTGATE, ADRIAN ORTIZ, KARL REUTER, ALEXANDER ZHDANKO, MATTHEW PENFIELD MOWER, KIRAN MATCHA, CHRISTOS XIOURAS
Year of Publication 09.05.2023
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Year of Publication 09.05.2023
Patent
A process toward the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-B][1,7]diazacyclotetradecin-5(6H)-one
REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, MATCHABA, KIRAN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG
Year of Publication 01.08.2022
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Year of Publication 01.08.2022
Patent