5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog
Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Enabled Process To Synthesize Monobactam 1 for Early Development
Tao, Yong, Lall, Manjinder S, Boyles, David C, Lilley, Susan C, Pattavina, Sebastian D, Rafka, Robert J, Sitter, Barbara J, Stewart, Andrew Morgan, Szeliga, Jan, Weisenburger, Gerald A
Published in Organic process research & development (15.11.2019)
Published in Organic process research & development (15.11.2019)
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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors
Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers
Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine
Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Structure-sweetness relationships for fructose analogs. Part III. 3-Deoxy-D-erythro-hexulose (3-deoxy-D-fructose): composition in solution and evaluation of sweetness
Szarek, Walter A, Rafka, Robert J, Yang, Te-Fang, Martin, Olivier R
Published in Canadian journal of chemistry (01.10.1995)
Published in Canadian journal of chemistry (01.10.1995)
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In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor
Li, Jin, Lynch, Michael P., DeMello, Kristin Lundy, Sakya, Subas M., Cheng, Hengmiao, Rafka, Robert J., Bronk, Brian S., Jaynes, Burton H., Kilroy, Carolyn, Mann, Donald W., Haven, Michelle L., Kolosko, Nicole L., Petras, Carol, Seibel, Scott B., Lund, Lisa A.
Published in Bioorganic & medicinal chemistry (01.03.2005)
Published in Bioorganic & medicinal chemistry (01.03.2005)
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Structure-sweetness relationships for fructose analogs. Part II. Synthesis and properties of 1,6-dihydroxy-2-hexanone, a simple analog of the ketohexoses, and X-ray structure determination of the corresponding dianhydrides
Szarek, Walter A, Martin, Olivier R, Rafka, Robert J, Cameron, T. Stanley
Published in Canadian journal of chemistry (01.06.1985)
Published in Canadian journal of chemistry (01.06.1985)
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