Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells
Morshedian, Ala, Kaylor, Joanna J., Ng, Sze Yin, Tsan, Avian, Frederiksen, Rikard, Xu, Tongzhou, Yuan, Lily, Sampath, Alapakkam P., Radu, Roxana A., Fain, Gordon L., Travis, Gabriel H.
Published in Neuron (Cambridge, Mass.) (19.06.2019)
Published in Neuron (Cambridge, Mass.) (19.06.2019)
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Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration
Lenis, Tamara L., Hu, Jane, Ng, Sze Yin, Jiang, Zhichun, Sarfare, Shanta, Lloyd, Marcia B., Esposito, Nicholas J., Samuel, William, Jaworski, Cynthia, Bok, Dean, Finnemann, Silvia C., Radeke, Monte J., Redmond, T. Michael, Travis, Gabriel H., Radu, Roxana A.
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2018)
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Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization
Pan, Chendong, Banerjee, Kalpita, Lehmann, Guillermo L., Almeida, Dena, Hajjar, Katherine A., Benedicto, Ignacio, Jiang, Zhichun, Radu, Roxana A., Thompson, David H., Rodriguez-Boulan, Enrique, Nociari, Marcelo M.
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2021)
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Genetic manipulation of rod-cone differences in mouse retina
Morshedian, Ala, Jiang, Zhichun, Radu, Roxana A, Fain, Gordon L, Sampath, Alapakkam P
Published in PloS one (06.05.2024)
Published in PloS one (06.05.2024)
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Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions
Bonilha, Vera L, Bell, Brent A, Hu, Jane, Milliner, Caroline, Pauer, Gayle J, Hagstrom, Stephanie A, Radu, Roxana A, Hollyfield, Joe G
Published in Investigative ophthalmology & visual science (01.07.2020)
Published in Investigative ophthalmology & visual science (01.07.2020)
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Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration
Fu, Cheng, Yang, Nan, Chuang, Jen-Zen, Nakajima, Nobuyuki, Iraha, Satoshi, Roy, Neeta, Wu, Zhenquan, Jiang, Zhichun, Otsu, Wataru, Radu, Roxana A., Yang, Howard Hua, Lee, Maxwell Ping, Worgall, Tilla S., Xiong, Wen-Cheng, Sung, Ching-Hwa
Published in Nature communications (23.07.2024)
Published in Nature communications (23.07.2024)
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CAR-T cell therapy targeting surface expression of TYRP1 to treat cutaneous and rare melanoma subtypes
Jilani, Sameeha, Saco, Justin D., Mugarza, Edurne, Pujol-Morcillo, Aleida, Chokry, Jeffrey, Ng, Clement, Abril-Rodriguez, Gabriel, Berger-Manerio, David, Pant, Ami, Hu, Jane, Gupta, Rubi, Vega-Crespo, Agustin, Baselga-Carretero, Ignacio, Chen, Jia M., Shin, Daniel Sanghoon, Scumpia, Philip, Radu, Roxana A., Chen, Yvonne, Ribas, Antoni, Puig-Saus, Cristina
Published in Nature communications (09.02.2024)
Published in Nature communications (09.02.2024)
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Journal Article
Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium
Cook, Jeremy D., Ng, Sze Yin, Lloyd, Marcia, Eddington, Shannan, Sun, Hui, Nathans, Jeremy, Bok, Dean, Radu, Roxana A., Travis, Gabriel H.
Published in The Journal of biological chemistry (29.12.2017)
Published in The Journal of biological chemistry (29.12.2017)
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Journal Article
Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration
Ng, Eunice Sze Yin, Kady, Nermin, Hu, Jane, Dave, Arpita, Jiang, Zhichun, Pei, Jacqueline, Gorin, Michael B, Matynia, Anna, Radu, Roxana A
Published in Cells (Basel, Switzerland) (01.11.2022)
Published in Cells (Basel, Switzerland) (01.11.2022)
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Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes
Hu, Jane, Pauer, Gayle J., Hagstrom, Stephanie A., Bok, Dean, DeBenedictis, Meghan J., Bonilha, Vera L., Hollyfield, Joe G., Radu, Roxana A.
Published in Redox biology (01.10.2020)
Published in Redox biology (01.10.2020)
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Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium
Nociari, Marcelo M, Lehmann, Guillermo L, Perez Bay, Andres E, Radu, Roxana A, Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R, Rodriguez-Boulan, Enrique
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
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The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
Lopes, Vanda S, Gibbs, Daniel, Libby, Richard T, Aleman, Tomas S, Welch, Darcy L, Lillo, Concepción, Jacobson, Samuel G, Radu, Roxana A, Steel, Karen P, Williams, David S
Published in Human molecular genetics (01.07.2011)
Published in Human molecular genetics (01.07.2011)
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Journal Article
The Role of Interphotoreceptor Retinoid-Binding Protein on the Translocation of Visual Retinoids and Function of Cone Photoreceptors
Jin, Minghao, Li, Songhua, Nusinowitz, Steven, Lloyd, Marcia, Hu, Jane, Radu, Roxana A, Bok, Dean, Travis, Gabriel H
Published in The Journal of neuroscience (04.02.2009)
Published in The Journal of neuroscience (04.02.2009)
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Flow of energy in the outer retina in darkness and in light
Linton, Jonathan D, Holzhausen, Lars C, Babai, Norbert, Song, Hongman, Miyagishima, Kiyoharu J, Stearns, George W, Lindsay, Ken, Wei, Junhua, Chertov, Andrei O, Peters, Theo A, Caffe, Romeo, Pluk, Helma, Seeliger, Mathias W, Tanimoto, Naoyuki, Fong, Kimberly, Bolton, Laura, Kuok, Denise L.T, Sweet, Ian R, Bartoletti, Theodore M, Radu, Roxana A, Travis, Gabriel H, Zagotta, Willam N, Townes-Anderson, Ellen, Parker, Ed, Van der Zee, Catharina E.E.M, Sampath, Alapakkam P, Sokolov, Maxim, Thoreson, Wallace B, Hurley, James B
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (11.05.2010)
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Journal Article
Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium
Kaylor, Joanna J, Radu, Roxana A, Bischoff, Nicholas, Makshanoff, Jacob, Hu, Jane, Lloyd, Marcia, Eddington, Shannan, Bianconi, Tran, Bok, Dean, Travis, Gabriel H
Published in PloS one (14.05.2015)
Published in PloS one (14.05.2015)
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Journal Article
Retinal Pigment Epithelium-Retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of All-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells
Radu, Roxana A., Hu, Jane, Peng, Jennifer, Bok, Dean, Mata, Nathan L., Travis, Gabriel H.
Published in The Journal of biological chemistry (11.07.2008)
Published in The Journal of biological chemistry (11.07.2008)
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Journal Article
Treatment with Isotretinoin Inhibits Lipofuscin Accumulation in a Mouse Model of Recessive Stargardt's Macular Degeneration
Radu, Roxana A., Mata, Nathan L., Nusinowitz, Steven, Liu, Xinran, Sieving, Paul A., Travis, Gabriel H.
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2003)
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