Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Park, Thomas J., Reznick, Jane, Peterson, Bethany L., Blass, Gregory, Omerbašić, Damir, Bennett, Nigel C., Kuich, P. Henning J. L., Zasada, Christin, Browe, Brigitte M., Hamann, Wiebke, Applegate, Daniel T., Radke, Michael H., Kosten, Tetiana, Lutermann, Heike, Gavaghan, Victoria, Eigenbrod, Ole, Bégay, Valérie, Amoroso, Vince G., Govind, Vidya, Minshall, Richard D., St. J. Smith, Ewan, Larson, John, Gotthardt, Michael, Kempa, Stefan, Lewin, Gary R.
Published in Science (American Association for the Advancement of Science) (21.04.2017)
Published in Science (American Association for the Advancement of Science) (21.04.2017)
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RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Guo, Wei, Schafer, Sebastian, Greaser, Marion L, Radke, Michael H, Liss, Martin, Govindarajan, Thirupugal, Maatz, Henrike, Schulz, Herbert, Li, Shijun, Parrish, Amanda M, Dauksaite, Vita, Vakeel, Padmanabhan, Klaassen, Sabine, Gerull, Brenda, Thierfelder, Ludwig, Regitz-Zagrosek, Vera, Hacker, Timothy A, Saupe, Kurt W, Dec, G William, Ellinor, Patrick T, MacRae, Calum A, Spallek, Bastian, Fischer, Robert, Perrot, Andreas, Özcelik, Cemil, Saar, Kathrin, Hubner, Norbert, Gotthardt, Michael
Published in Nature medicine (01.05.2012)
Published in Nature medicine (01.05.2012)
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Journal Article
Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
Rudolph, Franziska, Fink, Claudia, Hüttemeister, Judith, Kirchner, Marieluise, Radke, Michael H., Lopez Carballo, Jacobo, Wagner, Eva, Kohl, Tobias, Lehnart, Stephan E., Mertins, Philipp, Gotthardt, Michael
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction
Friebel, Julian, Weithauser, Alice, Witkowski, Marco, Rauch, Bernhard H, Savvatis, Konstantinos, Dörner, Andrea, Tabaraie, Termeh, Kasner, Mario, Moos, Verena, Bösel, Diana, Gotthardt, Michael, Radke, Michael H, Wegner, Max, Bobbert, Peter, Lassner, Dirk, Tschöpe, Carsten, Schutheiss, Heinz-Peter, Felix, Stephan B, Landmesser, Ulf, Rauch, Ursula
Published in European heart journal (21.10.2019)
Published in European heart journal (21.10.2019)
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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Grosch, Markus, Schraft, Laura, Chan, Adrian, Küchenhoff, Leonie, Rapti, Kleopatra, Ferreira, Anne-Maud, Kornienko, Julia, Li, Shengdi, Radke, Michael H., Krämer, Chiara, Clauder-Münster, Sandra, Perlas, Emerald, Backs, Johannes, Gotthardt, Michael, Dieterich, Christoph, van den Hoogenhof, Maarten M. G., Grimm, Dirk, Steinmetz, Lars M.
Published in Nature communications (22.06.2023)
Published in Nature communications (22.06.2023)
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Journal Article
Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling
Liss, Martin, Radke, Michael H, Eckhard, Jamina, Neuenschwander, Martin, Dauksaite, Vita, von Kries, Jens-Peter, Gotthardt, Michael
Published in PloS one (11.06.2018)
Published in PloS one (11.06.2018)
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Journal Article
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
Radke, Michael H, Peng, Jun, Wu, Yiming, McNabb, Mark, Nelson, O. Lynne, Granzier, Henk, Gotthardt, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
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Journal Article
The tight junction protein CAR regulates cardiac conduction and cell-cell communication
Lisewski, Ulrike, Shi, Yu, Wrackmeyer, Uta, Fischer, Robert, Chen, Chen, Schirdewan, Alexander, Jüttner, Rene, Rathjen, Fritz, Poller, Wolfgang, Radke, Michael H, Gotthardt, Michael
Published in The Journal of experimental medicine (29.09.2008)
Published in The Journal of experimental medicine (29.09.2008)
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Journal Article
Titin based viscosity in ventricular physiology: An integrative investigation of PEVK–actin interactions
Chung, Charles S, Methawasin, Methajit, Nelson, O. Lynne, Radke, Michael H, Hidalgo, Carlos G, Gotthardt, Michael, Granzier, Henk L
Published in Journal of molecular and cellular cardiology (01.09.2011)
Published in Journal of molecular and cellular cardiology (01.09.2011)
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Journal Article
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes
Radke, Michael H, Polack, Christopher, Methawasin, Mei, Fink, Claudia, Granzier, Henk L, Gotthardt, Michael
Published in Circulation (New York, N.Y.) (09.04.2019)
Published in Circulation (New York, N.Y.) (09.04.2019)
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Journal Article
Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue
Radke, Michael H, Badillo-Lisakowski, Victor, Britto-Borges, Thiago, Kubli, Dieter A, Jüttner, René, Parakkat, Pragati, Carballo, Jacobo Lopez, Hüttemeister, Judith, Liss, Martin, Hansen, Arne, Dieterich, Christoph, Mullick, Adam E, Gotthardt, Michael
Published in Science translational medicine (01.12.2021)
Published in Science translational medicine (01.12.2021)
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Journal Article
Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics
Elhamine, Fatiha, Radke, Michael H, Pfitzer, Gabriele, Granzier, Henk, Gotthardt, Michael, Stehle, Robert
Published in Journal of cell science (01.09.2014)
Published in Journal of cell science (01.09.2014)
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Journal Article
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
Maatz, Henrike, Jens, Marvin, Liss, Martin, Schafer, Sebastian, Heinig, Matthias, Kirchner, Marieluise, Adami, Eleonora, Rintisch, Carola, Dauksaite, Vita, Radke, Michael H, Selbach, Matthias, Barton, Paul J R, Cook, Stuart A, Rajewsky, Nikolaus, Gotthardt, Michael, Landthaler, Markus, Hubner, Norbert
Published in The Journal of clinical investigation (01.08.2014)
Published in The Journal of clinical investigation (01.08.2014)
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Journal Article
Truncation of Titin’s Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction
Granzier, Henk L, Radke, Michael H, Peng, Jun, Westermann, Dirk, Nelson, O Lynne, Rost, Katharina, King, Nicholas M.P, Yu, Qianli, Tschöpe, Carsten, McNabb, Mark, Larson, Douglas F, Labeit, Siegfried, Gotthardt, Michael
Published in Circulation research (11.09.2009)
Published in Circulation research (11.09.2009)
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Journal Article
RBM20 ASOs improve ventricular filling in a mouse model with increased titin-based stiffness
Badillo Lisakowski, Victor, Radke, Michael H., Britto-Borges, Thiago, Kubli, Dieter, Jüttner, René, Parakkat, Pragati, López Carballo, Jacobo, Hüttemeister, Judith, Liss, Martin, Hansen, Arne, Dieterich, Christoph, Mullick, Adam, Gotthardt, Michael
Published in Biophysical journal (11.02.2022)
Published in Biophysical journal (11.02.2022)
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Journal Article
The tight junction protein CAR regulates cardiac conduction and cell–cell communication
Lisewski, Ulrike, Shi, Yu, Wrackmeyer, Uta, Fischer, Robert, Chen, Chen, Schirdewan, Alexander, Jüttner, Rene, Rathjen, Fritz, Poller, Wolfgang, Radke, Michael H., Gotthardt, Michael
Published in The Journal of cell biology (22.09.2008)
Published in The Journal of cell biology (22.09.2008)
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