Tanezumab Reduces Osteoarthritic Hip Pain: Results of a Randomized, Double‐Blind, Placebo‐Controlled Phase III Trial
Brown, Mark T., Murphy, Frederick T., Radin, David M., Davignon, Isabelle, Smith, Michael D., West, Christine R.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2013)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2013)
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Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial
Brown, Mark T, Murphy, Frederick T, Radin, David M, Davignon, Isabelle, Smith, Michael D, West, Christine R
Published in The journal of pain (01.08.2012)
Published in The journal of pain (01.08.2012)
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Enzyme replacement for GM1-gangliosidosis: Uptake, lysosomal activation, and cellular disease correction using a novel β-galactosidase:RTB lectin fusion
Condori, Jose, Acosta, Walter, Ayala, Jorge, Katta, Varun, Flory, Ashley, Martin, Reid, Radin, Jonathan, Cramer, Carole L., Radin, David N.
Published in Molecular genetics and metabolism (01.02.2016)
Published in Molecular genetics and metabolism (01.02.2016)
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Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis
Weesner, Jason Andrew, Annunziata, Ida, Yang, Tianhong, Acosta, Walter, Gomero, Elida, Hu, Huimin, van de Vlekkert, Diantha, Ayala, Jorge, Qiu, Xiaohui, Fremuth, Leigh Ellen, Radin, David N, Cramer, Carole L, d'Azzo, Alessandra
Published in Cells (Basel, Switzerland) (01.08.2022)
Published in Cells (Basel, Switzerland) (01.08.2022)
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Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): an interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study
Tye-Din, Jason A, Daveson, A James M, Goel, Gautam, Goldstein, Kaela E, Hand, Holly L, Neff, Kristin M, Popp, Alina, Taavela, Juha, Maki, Markku, Isola, Jorma, Williams, Leslie J, Truitt, Kenneth E, Anderson, Robert P
Published in The lancet. Gastroenterology & hepatology (01.05.2023)
Published in The lancet. Gastroenterology & hepatology (01.05.2023)
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Quality assessment of recombinant proteins produced in plants
Medrano, Giuliana, Dolan, Maureen C, Condori, Jose, Radin, David N, Cramer, Carole L
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2012)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2012)
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High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells
Acosta, Walter, Martin, Reid, Radin, David N., Cramer, Carole L.
Published in Data in brief (01.03.2016)
Published in Data in brief (01.03.2016)
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Intracellular stability and efficacy of β-galactosidase fusions as a GM1 gangliosidosis ERT are significantly influenced by mouse versus human multi-enzyme complex interactions
Yang, Tianhong, Acosta, Walter L., Ayala, Jorge, Pattada, Shivakumar, Riley, Kassandra, Hampton, Rachel, Radin, David, Cramer, Carole L.
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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RTB-lectin facilitates the distribution of enzymes across the blood-brain-barrier and correction in the MPS IIIA mouse model
Pattada, Shivakumar D., Ayala, Jorge, Acosta, Walter L., Yang, Tianhong, Riley, Kassandra, Hampton, Rachel, Hampton, Eddie J., Cramer, Carole L., Radin, David
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Journal Article
Preclinical enzyme replacement therapy with a recombinant β-galactosidase-lectin fusion for CNS delivery and treatment of GM1-gangliosidosis
Weesner, Jason A., van de Vlekkert, Diantha, Acosta, Walter L., Yang, Tianhong, Gomero, Elida M., Hu, Huimin, Radin, David, Cramer, Carole L., d'Azzo, Alessandra
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Lectin-mediated delivery to tissues and organs affected by the development of anti-drug antibodies in MPS I mouse model
Acosta, Walter, Hampton, Rachel, Ayala, Jorge, Pattada, Shivakumar, Riley, Kassandra, Yang, Tianhong, Hampton, Eddie J., Sanchez, Luis M., Cubero, Maria, Cofre, Carmela Unnold, Martin, Reid, Solano, Aura D., Radin, David, Cramer, Carole L.
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Correction of bone pathology in MPS I mouse model using lectin-mediated delivery
Acosta, Walter L., Hampton, Rachel, Ayala, Jorge, Yang, Tianhong, Pattada, Shivakumar, Riley, Kassandra, Hampton, Eddie J., Cubero, Maria Fernanda, Sanchez, Luis M., Cofre, Carmela Unnold, Martin, Reid, Solano, Aura D., Radin, David, Cramer, Carole L.
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip
Tive, Leslie, Bello, Alfonso E, Radin, David, Schnitzer, Thomas J, Nguyen, Ha, Brown, Mark T, West, Christine R
Published in Journal of pain research (01.01.2019)
Published in Journal of pain research (01.01.2019)
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Receptor-independent mechanisms of RTB lectin-mediated ERT delivery provide unique advantages in enzyme uptake capacity, transcytosis, and lysosomal correction
Martin, Reid, Acosta, Walter, Ayala, Jorge, Katta, Varun, Flory, Ashley, Radin, Jonathan, Devaiah, Shivakumar, Cramer, Carole, Radin, David
Published in Molecular genetics and metabolism (01.01.2017)
Published in Molecular genetics and metabolism (01.01.2017)
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Novel bioproduction and delivery strategies for MPS IIIA enzyme replacement therapeutics
Condori, Jose, Katta, Varun, Acosta, Walter, Ayala, Jorge, Flory, Ashley, Radin, Jonathan, Davis, Samantha, Cramer, Carole L., Radin, David N.
Published in Molecular genetics and metabolism (01.02.2016)
Published in Molecular genetics and metabolism (01.02.2016)
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Enzyme replacement therapy with α-L-iduronidase and lectin RTB fusion protein in treating murine Hurler syndrome
Ou, Li, Acosta, Walter, Koniar, Brenda L., Cooksley, Renee D., Cramer, Carole L., Radin, David N., Whitley, Chester B.
Published in Molecular genetics and metabolism (01.02.2016)
Published in Molecular genetics and metabolism (01.02.2016)
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Uptake, lysosomal activation, and disease correction in GM1 Gangliosidosis cells by plant-made β-galactosidase: Lectin fusions
Ayala, Jorge, Acosta, Walter, Condori, Jose, Annunziata, Ida, Katta, Varun, Flory, Ashley, Martin, Reid, Radin, Jonathan, Cramer, Carole L., d'Azzo, Alessandra, Radin, David N.
Published in Molecular genetics and metabolism (01.02.2016)
Published in Molecular genetics and metabolism (01.02.2016)
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Journal Article
Lectin-mediated delivery of α-L-iduronidase: A novel approach for MPS I enzyme replacement therapy
Acosta, Walter L., Ou, Li, Ayala, Jorge, Condori, Jose, Katta, Varun, Flory, Ashley, Martin, Reid, Radin, Jonathan, Whitley, Chester B., Cramer, Carole L., Radin, David N.
Published in Molecular genetics and metabolism (01.02.2016)
Published in Molecular genetics and metabolism (01.02.2016)
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Pooled Analysis of Tanezumab Efficacy and Safety with Subgroup Analyses of Phase III Clinical Trials in Patients with Osteoarthritis Pain of the Knee or Hip [Corrigendum]
Tive, Leslie, Bello, Alfonso E, Radin, David, Schnitzer, Thomas J, Nguyen, Ha, Brown, Mark T, West, Christine R
Published in Journal of pain research (30.09.2020)
Published in Journal of pain research (30.09.2020)
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