Loading…
A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice
DeMattos, Ronald B., Lu, Jirong, Tang, Ying, Racke, Margaret M., DeLong, Cindy A., Tzaferis, John A., Hole, Justin T., Forster, Beth M., McDonnell, Peter C., Liu, Feng, Kinley, Robert D., Jordan, William H., Hutton, Michael L.
Published in Neuron (Cambridge, Mass.) (06.12.2012)
Published in Neuron (Cambridge, Mass.) (06.12.2012)
Get full text
Journal Article
Loading…
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo
Burgess, Braydon L., Parkinson, Pamela F., Racke, Margaret M., Hirsch-Reinshagen, Veronica, Fan, Jianjia, Wong, Charmaine, Stukas, Sophie, Theroux, Louise, Chan, Jeniffer Y., Donkin, James, Wilkinson, Anna, Balik, Danielle, Christie, Brian, Poirier, Judes, Lütjohann, Dieter, DeMattos, Ronald B., Wellington, Cheryl L.
Published in Journal of lipid research (01.06.2008)
Published in Journal of lipid research (01.06.2008)
Get full text
Journal Article
Loading…
Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models
Latta‐Mahieu, Martine, Elmer, Bradford, Bretteville, Alexis, Wang, Yaming, Lopez‐Grancha, Mati, Goniot, Philippe, Moindrot, Nicolas, Ferrari, Paul, Blanc, Véronique, Schussler, Nathalie, Brault, Emmanuel, Roudières, Valérie, Blanchard, Véronique, Yang, Zhi‐Yong, Barneoud, Pascal, Bertrand, Philippe, Roucourt, Bart, Carmans, Sofie, Bottelbergs, Astrid, Mertens, Liesbeth, Wintmolders, Cindy, Larsen, Peter, Hersley, Caroline, McGathey, Tyler, Racke, Margaret M., Liu, Ling, Lu, Jirong, O'Neill, Michael J., Riddell, David R., Ebneth, Andreas, Nabel, Gary J., Pradier, Laurent
Published in Glia (01.03.2018)
Published in Glia (01.03.2018)
Get full text
Journal Article
Loading…
A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics
Song, Linan, Lachno, D. Richard, Hanlon, David, Shepro, Adam, Jeromin, Andreas, Gemani, Dipika, Talbot, Jayne A., Racke, Margaret M., Dage, Jeffrey L., Dean, Robert A.
Published in Alzheimer's research & therapy (15.12.2016)
Published in Alzheimer's research & therapy (15.12.2016)
Get full text
Journal Article
Loading…
Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β
Racke, Margaret M., Boone, Laura I., Hepburn, Deena L., Parsadainian, Maia, Bryan, Matthew T., Ness, Daniel K., Piroozi, Kathy S., Jordan, William H., Brown, Donna D., Hoffman, Wherly P., Holtzman, David M., Bales, Kelly R., Gitter, Bruce D., May, Patrick C., Paul, Steven M., DeMattos, Ronald B.
Published in The Journal of neuroscience (19.01.2005)
Published in The Journal of neuroscience (19.01.2005)
Get full text
Journal Article
Loading…
β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
Published in Alzheimer's research & therapy (01.01.2014)
Published in Alzheimer's research & therapy (01.01.2014)
Get full text
Journal Article
Loading…
OPTIMIZATION OF THE PHARMACOKINETIC (PK) AND PHARMACODYNAMIC (PD) PROPERTIES OF AN ANTI-ABETA ANTIBODY M266 FAB FRAGMENT VARIANT BY SITE-SPECIFIC PEGYLATION
Racke, Margaret M, Day, Theresa A, Hole, Justin T, Chow, Chi-Kin, Lu, Jirong, DeMattos, Ronald B
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
Get full text
Journal Article
Loading…
Validation of assays for measurement of amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer's disease treated with solanezumab
Lachno, D Richard, Evert, Barbara A, Vanderstichele, Hugo, Robertson, Michael, Demattos, Ronald B, Konrad, Robert J, Talbot, Jayne A, Racke, Margaret M, Dean, Robert A
Published in Journal of Alzheimer's disease (01.01.2013)
Published in Journal of Alzheimer's disease (01.01.2013)
Get more information
Journal Article
Loading…
COMBINATION THERAPY WITH A PLAQUE-SPECIFIC ABETA ANTIBODY AND A BACE INHIBITOR RESULTS IN DRAMATIC PLAQUE REDUCTION IN A DOSE-DEPENDENT MANNER IN AGED PDAPP TRANSGENIC MICE
Hole, Justin T, Racke, Margaret M, Tzaferis, John A, Liu, Feng, Oluoch, Herold, Ahmed, Zeshan, Fisher, Alice, Anderson, Wesley, Iversent, Philip, Gonzales, Celedon, Yang, Zhixiang, Boggs, Leonard N, Monk, Scott A, Mergott, Dustin J, Yang, Ying YT, Lu, Jirong, Irizarry, Michael C, Sims, John R, May, Patrick C, Hutton, Michael, Nordstedt, Christer, DeMattos, Ronald B
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
Get full text
Journal Article
Loading…
Investigation of dose-responses and longitudinal effects of combination therapy with a plaque-specific amyloid beta antibody and bace inhibitor in aged transgenic mice
DeMattos, Ronald B, Racke, Margaret M, Hole, Justin T, Tzaferis, John A, Liu, Feng, Ahmed, Zeshan, Fisher, Alice, Day, Theresa A, Anderson, Wesley, Iversent, Philip, Gonzales, Celedon, Yang, Zhixiang, Boggs, Leonard, Monk, Scott A, Mergott, Dustin J, Yang, Ying Y.T, Lu, Jirong, Irizarry, Michael C, Sims, John R, May, Patrick C, Hutton, Michael L, Nordstedt, Christer
Published in Alzheimer's & dementia (01.07.2015)
Published in Alzheimer's & dementia (01.07.2015)
Get full text
Journal Article
Loading…
Identification, characterization, and comparison of amino-terminally truncated Aβ42 peptides in Alzheimer's disease brain tissue and in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment
DeMattos, Ronald B, Racke, Margaret M, Gelfanova, Valentina, Forster, Beth, Knierman, Michael D, Bryan, Matthew T, Hale, John E, Dean, Robert A, Paul, Steven M, Siemers, Eric R
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
Get full text
Journal Article
Loading…
Loading…
Activation of caspase‐3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells
Racke, Margaret M., Mosior, Marian, Kovacevic, Steve, Chang, Chan Hsin S., Glasebrook, Andrew L., Roehm, Neal W., Na, Songqing
Published in Journal of neurochemistry (01.03.2002)
Published in Journal of neurochemistry (01.03.2002)
Get full text
Journal Article
Loading…
THE ROLE OF BACE1 INHIBITION ON Aβ PATHOLOGY IN YOUNG AND AGED PDAPP MICE
Yang, Zhixiang, Thompson, Linda, Boggs, Leonard N., Racke, Margaret M., Riddell, David R., McKinzie, David L.
Published in Alzheimer's & dementia (01.07.2018)
Published in Alzheimer's & dementia (01.07.2018)
Get full text
Journal Article
Loading…
P2‐058: THE ROLE OF BACE1 INHIBITION ON Aβ PATHOLOGY IN YOUNG AND AGED PDAPP MICE
Yang, Zhixiang, Thompson, Linda, Boggs, Leonard N., Racke, Margaret M., Riddell, David R., McKinzie, David L.
Published in Alzheimer's & dementia (01.07.2018)
Published in Alzheimer's & dementia (01.07.2018)
Get full text
Journal Article
Loading…
Loading…
P1‐081: Optimization of the Pharmacokinetic (PK) and Pharmacodynamic (PD) Properties of an Anti‐Abeta Antibody M266 FAB Fragment Variant by Site‐Specific Pegylation
Racke, Margaret M., Day, Theresa A., Hole, Justin T., Chow, Chi-Kin, Lu, Jirong, DeMattos, Ronald B.
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
Get full text
Journal Article
Loading…
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-[beta] burden in several amyloid transgenic mouse models
Latta-Mahieu, Martine, Elmer, Bradford, Bretteville, Alexis, Wang, Yaming, Lopez-Grancha, Mati, Goniot, Philippe, Moindrot, Nicolas, Ferrari, Paul, Blanc, Véronique, Schussler, Nathalie, Brault, Emmanuel, Roudieres, Valérie, Blanchard, Véronique, Yang, Zhi-Yong, Barneoud, Pascal, Bertrand, Philippe, Roucourt, Bart, Carmans, Sofie, Bottelbergs, Astrid, Mertens, Liesbeth, Wintmolders, Cindy, Larsen, Peter, Hersley, Caroline, McGathey, Tyler, Racke, Margaret M, Liu, Ling, Lu, Jirong, O'Neill, Michael J, Riddell, David R, Ebneth, Andreas, Nabel, Gary J, Pradier, Laurent
Published in Glia (01.03.2018)
Published in Glia (01.03.2018)
Get full text
Journal Article
Loading…
P4‐401: Combination Therapy with a Plaque‐Specific Abeta Antibody And A Bace Inhibitor Results in Dramatic Plaque Reduction in a Dose‐Dependent Manner in Aged Pdapp Transgenic Mice
Hole, Justin T., Racke, Margaret M., Tzaferis, John A., Liu, Feng, Oluoch, Herold, Ahmed, Zeshan, Fisher, Alice, Anderson, Wesley, Iversent, Philip, Gonzales, Celedon, Yang, Zhixiang, Boggs, Leonard N., Monk, Scott A., Mergott, Dustin J., Yang, Ying YT, Lu, Jirong, Irizarry, Michael C., Sims, John R., May, Patrick C., Hutton, Michael, Nordstedt, Christer, DeMattos, Ronald B.
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
Get full text
Journal Article
Loading…
[P2–049]: A COMPETITIVE EX‐VIVO SCREENING ASSAY TO DETERMINE ABETA ANTIBODY MEDIATED PHAGOCYTOSIS AND PLAQUE SPECIFICITY
Liu, Feng, Oluoch, Herold, Tzaferis, John A., Hole, Justin T., Demattos, Ronald B., Racke, Margaret M.
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
Get full text
Journal Article