Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking
Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Published in PloS one (22.03.2010)
Published in PloS one (22.03.2010)
Get full text
Journal Article
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
Hadano, Shinji, Benn, Susanna C., Kakuta, Shigeru, Otomo, Asako, Sudo, Katsuko, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Shefner, Jeremy M., Cox, Gregory A., Iwakura, Yoichiro, Brown, Robert H., Ikeda, Joh-E
Published in Human molecular genetics (15.01.2006)
Published in Human molecular genetics (15.01.2006)
Get full text
Journal Article
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth
Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Onoe, Kyuichiro, Osuga, Hitoshi, Hadano, Shinji, Ikeda, Joh-E.
Published in Biochemical and biophysical research communications (23.05.2008)
Published in Biochemical and biophysical research communications (23.05.2008)
Get full text
Journal Article
Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice
Hadano, Shinji, Yoshii, Yasuhiro, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Pan, Lei, Kakuta, Shigeru, Iwasaki, Yasuo, Iwakura, Yoichiro, Ikeda, Joh-E
Published in Neuroscience research (01.10.2010)
Published in Neuroscience research (01.10.2010)
Get full text
Journal Article
Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking
Kunita, Ryota, Otomo, Asako, Mizumura, Hikaru, Suzuki, Kyoko, Showguchi-Miyata, Junko, Yanagisawa, Yoshiko, Hadano, Shinji, Ikeda, Joh-E
Published in The Journal of biological chemistry (10.09.2004)
Published in The Journal of biological chemistry (10.09.2004)
Get full text
Journal Article
ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics
Suzuki-Utsunomiya, Kyoko, Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Mizumura, Hikaru, Osuga, Hitoshi, Ikeda, Joh-E
Published in Biochemical and biophysical research communications (09.03.2007)
Published in Biochemical and biophysical research communications (09.03.2007)
Get full text
Journal Article
Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Published in PloS one (22.03.2010)
Published in PloS one (22.03.2010)
Get full text
Journal Article
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics
Hadano, Shinji, Otomo, Asako, Suzuki-Utsunomiya, Kyoko, Kunita, Ryota, Yanagisawa, Yoshiko, Showguchi-Miyata, Junko, Mizumura, Hikaru, Ikeda, Joh-E
Published in FEBS letters (24.09.2004)
Published in FEBS letters (24.09.2004)
Get full text
Journal Article
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Ikeda, Joh-E, Hadano, Shinji
Published in FEBS letters (09.03.2011)
Published in FEBS letters (09.03.2011)
Get full text
Journal Article
Predominant expression of a Z-chromosome-linked immunoglobulin superfamily gene, ZOV3, in steroidogenic cells of ovarian follicles and in embryonic gonads of chickens
Kunita, Ryota, Nakabayashi, Osamu, Mizuno, Shigeki, Kikuchi, Tateki
Published in Differentiation (London) (01.11.1997)
Published in Differentiation (London) (01.11.1997)
Get full text
Journal Article
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
Otomo, Asako, Hadano, Shinji, Okada, Takeya, Mizumura, Hikaru, Kunita, Ryota, Nishijima, Hitoshi, Showguchi-Miyata, Junko, Yanagisawa, Yoshiko, Kohiki, Eri, Suga, Etsuko, Yasuda, Masanori, Osuga, Hitoshi, Nishimoto, Takeharu, Narumiya, Shuh, Ikeda, Joh-E
Published in Human molecular genetics (15.07.2003)
Published in Human molecular genetics (15.07.2003)
Get full text
Journal Article
Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1.sup.H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Published in PloS one (22.03.2010)
Published in PloS one (22.03.2010)
Get full text
Journal Article
Disturbance of endolysosomal protein degradation underlies the pathogenesis of ALS2-linked motor neuron diseases
Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Published in Neuroscience research (2010)
Published in Neuroscience research (2010)
Get full text
Journal Article
Molecular cloning of acid α-glucosidase cDNA of Japanese quail ( Coturnix coturnix japonica) and the lack of its mRNA in acid maltase deficient quails
Kunita, Ryota, Nakabayashi, Osamu, Wu, Jer-Yuarn, Hagiwara, Yasuko, Mizutani, Makoto, Pennybacker, Mark, Chen, Yuan-Tsong, Kikuchi, Tateki
Published in Biochimica et biophysica acta (31.12.1997)
Published in Biochimica et biophysica acta (31.12.1997)
Get full text
Journal Article
AVIÄRES EXPRESSIONSSYSTEM FÜR FREMDPROTEINE
PAIN, BERTRAND, CHAMPION-ARNAUD, PATRICK, SAMARUT, JACQUES, VALARCHE, ISABELLE, SOBCZYK, ANDRE, KUNITA, RYOTA
Year of Publication 24.09.2009
Get full text
Year of Publication 24.09.2009
Patent
AVIÄRES EXPRESSIONSSYSTEM FÜR FREMDPROTEINE
PAIN, BERTRAND, CHAMPION-ARNAUD, PATRICK, SAMARUT, JACQUES, VALARCHE, ISABELLE, SOBCZYK, ANDRE, KUNITA, RYOTA
Year of Publication 15.05.2008
Get full text
Year of Publication 15.05.2008
Patent