Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities
Devasthale, Pratik V, Chen, Sean, Jeon, Yoon, Qu, Fucheng, Shao, Chunning, Wang, Wei, Zhang, Hao, Cap, Michael, Farrelly, Dennis, Golla, Rajasree, Grover, Gary, Harrity, Thomas, Ma, Zhengping, Moore, Lisa, Ren, Jimmy, Seethala, Ramakrishna, Cheng, Lin, Sleph, Paul, Sun, Wei, Tieman, Aaron, Wetterau, John R, Doweyko, Arthur, Chandrasena, Gamini, Chang, Shu Y, Humphreys, W. Griffith, Sasseville, Vito G, Biller, Scott A, Ryono, Denis E, Selan, Fred, Hariharan, Narayanan, Cheng, Peter T. W
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
Get full text
Journal Article
Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
HARRITY, Thomas, FARRELLY, Dennis, WEI WANG, HAO ZHANG, FENDERSON, William, CHEN, Sean, DEVASTHALE, Pratik, JEON, Yoon, SEETHALA, Ramakrishna, YANG, Wen-Pin, REN, Jimmy, MIN ZHOU, TIEMAN, Aaron, RYONO, Denis, BILLER, Scott, MOOKHTIAR, Kasim A, WETTERAU, John, GREGG, Richard, CHENG, Peter T, HARIHARAN, Narayanan, CUIXIA CHU, KUNSELMAN, Lori, LIQUN GU, PONTICIELLO, Randolph, CAP, Michael, FUCHENG QU, CHUNNING SHAO
Published in Diabetes (New York, N.Y.) (01.01.2006)
Published in Diabetes (New York, N.Y.) (01.01.2006)
Get full text
Journal Article
Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists
Zhang, Hao, Ryono, Denis E., Devasthale, Pratik, Wang, Wei, O’Malley, Kevin, Farrelly, Dennis, Gu, Liqun, Harrity, Thomas, Cap, Michael, Chu, Cuixia, Locke, Kenneth, Zhang, Litao, Lippy, Jonathan, Kunselman, Lori, Morgan, Nathan, Flynn, Neil, Moore, Lisa, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Xu, Carrie, Doweyko, Arthur M., Bell, Aneka, Chang, Chiehying, Muckelbauer, Jodi, Zahler, Robert, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Get full text
Journal Article
alpha.-Hydroxy Phosphinyl-Based Inhibitors of Human Renin
Patel, Dinesh V, Rielly-Gauvin, Katherine, Ryono, Denis E, Free, Charles A, Rogers, W. Lynn, Smith, Sandra A, DeForrest, Jack M, Oehl, Robert S, Petrillo, Edward W
Published in Journal of medicinal chemistry (01.10.1995)
Published in Journal of medicinal chemistry (01.10.1995)
Get full text
Journal Article
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta
Hangeland, Jon J., Doweyko, Arthur M., Dejneka, Tamara, Friends, Todd J., Devasthale, Pratik, Mellström, Karin, Sandberg, Johnny, Grynfarb, Marlena, Sack, John S., Einspahr, Howard, Färnegårdh, Mathias, Husman, Bolette, Ljunggren, Jan, Koehler, Konrad, Sheppard, Cheryl, Malm, Johan, Ryono, Denis E.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Get full text
Journal Article
Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase
Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
Get full text
Journal Article
Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists
Ye, Xiang-Yang, Li, Yi-Xin, Farrelly, Dennis, Flynn, Neil, Gu, Liqun, Locke, Kenneth T., Lippy, Jonathan, O’Malley, Kevin, Twamley, Celeste, Zhang, Litao, Ryono, Denis E., Zahler, Robert, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
Get full text
Journal Article
Discovery of tertiary aminoacids as dual PPARα/γ agonists-I
Devasthale, Pratik V., Chen, Sean, Jeon, Yoon, Qu, Fucheng, Ryono, Denis E., Wang, Wei, Zhang, Hao, Cheng, Lin, Farrelly, Dennis, Golla, Rajasree, Grover, Gary, Ma, Zhengping, Moore, Lisa, Seethala, Ramakrishna, Sun, Wei, Doweyko, Arthur M., Chandrasena, Gamini, Sleph, Paul, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Get full text
Journal Article
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141
Garg, Neeraj, Li, Yi-Lin, Garcia Collazo, Ana Maria, Litten, Chris, Ryono, Denis E., Zhang, Minsheng, Caringal, Yolanda, Brigance, Robert P., Meng, Wei, Washburn, William N., Agback, Peter, Mellström, Karin, Rehnmark, Stefan, Rahimi-Ghadim, Mahmoud, Norin, Thomas, Grynfarb, Marlena, Sandberg, Johnny, Grover, Gary, Malm, Johan
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Get full text
Journal Article
A new class of high affinity thyromimetics containing a phenyl-naphthylene core
Hangeland, Jon J., Friends, Todd J., Doweyko, Arthur M., Mellström, Karin, Sandberg, Johnny, Grynfarb, Marlena, Ryono, Denis E.
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Get full text
Journal Article
Activated ketone based inhibitors of human renin
Patel, Dinesh V, Rielly-Gauvin, Katherine, Ryono, Denis E, Free, Charles A, Smith, Sandra A, Petrillo, Edward W
Published in Journal of medicinal chemistry (20.08.1993)
Published in Journal of medicinal chemistry (20.08.1993)
Get full text
Journal Article
Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides
Robl, Jeffrey A, Sulsky, Richard, Sieber-McMaster, Ellen, Ryono, Denis E, Cimarusti, Maria P, Simpkins, Ligaya M, Karanewsky, Donald S, Chao, Sam, Asaad, Magdi M, Seymour, Andrea A, Fox, Maxine, Smith, Patricia L, Trippodo, Nick C
Published in Journal of medicinal chemistry (28.01.1999)
Published in Journal of medicinal chemistry (28.01.1999)
Get full text
Journal Article
Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitors
Robl, Jeffrey A, Cimarusti, Maria P, Simpkins, Ligaya M, Brown, Baerbel, Ryono, Denis E, Bird, J. Eileen, Asaad, Magdi M, Schaeffer, Thomas R, Trippodo, Nick C
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
Get full text
Journal Article
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1 H -pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O'Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Jr, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
Get full text
Journal Article
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T. W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
Get full text
Journal Article
Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P1/P1‘ Compounds: Correlation between Lipophilicity and Cytotoxicity
Chen, Ping, Cheng, Peter T. W, Alam, Masud, Beyer, Barbara D, Bisacchi, Gregory S, Dejneka, Tamara, Evans, Adelaide J, Greytok, Jill A, Hermsmeier, Mark A, Humphreys, W. Griffith, Jacobs, Glenn A, Kocy, Octavian, Lin, Pin-Fang, Lis, Karen A, Marella, Michael A, Ryono, Denis E, Sheaffer, Amy K, Spergel, Steven H, Sun, Chong-qing, Tino, Joseph A, Vite, Gregory, Colonno, Richard J, Zahler, Robert, Barrish, Joel C
Published in Journal of medicinal chemistry (10.05.1996)
Published in Journal of medicinal chemistry (10.05.1996)
Get full text
Journal Article
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
Zhang, Hao, Ding, Charles Z., Lai, Zhi, Chen, Sean S., Devasthale, Pratik, Herpin, Tim, Morton, George, Qu, Fucheng, Ryono, Denis, Smirk, Rebecca, Wang, Wei, Wu, Shung, Ye, Xiang-Xang, Li, Yi-Xin, Apedo, Atsu, Farrelly, Dennis, Wang, Tao, Gu, Liqun, Morgan, Nathan, Flynn, Neil, Chu, Cuixia, Kunselman, Lori, Lippy, Jonathan, Locke, Kenneth, O’Malley, Kevin, Harrity, Thomas, Cap, Michael, Zhang, Lisa, Hosagrahara, Vinayak, Kadiyala, Pathanjali, Xu, Carrie, Doweyko, Arthur M., Zahler, Robert, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Get full text
Journal Article
Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)
Li, Jun, Kennedy, Lawrence J, Shi, Yan, Tao, Shiwei, Ye, Xiang-Yang, Chen, Stephanie Y, Wang, Ying, Hernández, Andrés S, Wang, Wei, Devasthale, Pratik V, Chen, Sean, Lai, Zhi, Zhang, Hao, Wu, Shung, Smirk, Rebecca A, Bolton, Scott A, Ryono, Denis E, Zhang, Huiping, Lim, Ngiap-Kie, Chen, Bang-Chi, Locke, Kenneth T, O’Malley, Kevin M, Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S, Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K, Cap, Michael, Kadiyala, Pathanjali, Hosagrahara, Vinayak, Zhang, Lisa, Xu, Carrie, Li, Yi-Xin, Muckelbauer, Jodi K, Chang, Chiehying, An, Yongmi, Krystek, Stanley R, Blanar, Michael A, Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T. W, Tino, Joseph A
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
Get full text
Journal Article
Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
Wang, Wei, Devasthale, Pratik, Farrelly, Dennis, Gu, Liqun, Harrity, Thomas, Cap, Michael, Chu, Cuixia, Kunselman, Lori, Morgan, Nathan, Ponticiello, Randy, Zebo, Rachel, Zhang, Litao, Locke, Kenneth, Lippy, Jonathan, O’Malley, Kevin, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Chang, Chiehying, Muckelbauer, Jodi, Doweyko, Arthur M., Zahler, Robert, Ryono, Denis, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
Get full text
Journal Article
Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor [alpha] Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)
Li, Jun, Kennedy, Lawrence J., Shi, Yan, Tao, Shiwei, Ye, Xiang-Yang, Chen, Stephanie Y., Wang, Ying, Hernndez, Andrs S., Wang, Wei, Devasthale, Pratik V., Chen, Sean, Lai, Zhi, Zhang, Hao, Wu, Shung, Smirk, Rebecca A., Bolton, Scott A., Ryono, Denis E., Zhang, Huiping, Lim, Ngiap-Kie, Chen, Bang-Chi, Locke, Kenneth T., OMalley, Kevin M., Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S., Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K., Cap, Michael, Kadiyala, Pathanjali, Hosagrahara, Vinayak, Zhang, Lisa, Xu, Carrie, Li, Yi-Xin, Muckelbauer, Jodi K., Chang, Chiehying, An, Yongmi, Krystek, Stanley R., Blanar, Michael A., Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T.W., Tino, Joseph A.
Published in Journal of medicinal chemistry (12.04.2010)
Published in Journal of medicinal chemistry (12.04.2010)
Get full text
Journal Article