The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans
Dowty, Martin E, Lin, Jinyan, Ryder, Tim F, Wang, Weiwei, Walker, Gregory S, Vaz, Alfin, Chan, Gary L, Krishnaswami, Sriram, Prakash, Chandra
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors
Walsky, Robert L, Bauman, Jonathan N, Bourcier, Karine, Giddens, Georgina, Lapham, Kimberly, Negahban, Andre, Ryder, Tim F, Obach, R Scott, Hyland, Ruth, Goosen, Theunis C
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
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Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach
Adusumalli, Sravani, Jamwal, Rohitash, Obach, R Scott, Ryder, Tim F, Leggio, Lorenzo, Akhlaghi, Fatemeh
Published in Drug metabolism and disposition (01.08.2019)
Published in Drug metabolism and disposition (01.08.2019)
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An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry
Bellenger, Justin, Koos, Martin R M, Avery, Melissa, Bundesmann, Mark, Ciszewski, Gregory, Khunte, Bhagyashree, Leverett, Carolyn, Ostner, Gregory, Ryder, Tim F, Farley, Kathleen A
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Journal Article
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1 H NMR for Parallel Medicinal Chemistry
Bellenger, Justin, Koos, Martin R M, Avery, Melissa, Bundesmann, Mark, Ciszewski, Gregory, Khunte, Bhagyashree, Leverett, Carolyn, Ostner, Gregory, Ryder, Tim F, Farley, Kathleen A
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Journal Article
Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies
Walker, Gregory S, Bauman, Jonathan N, Ryder, Tim F, Smith, Evan B, Spracklin, Douglas K, Obach, R Scott
Published in Drug metabolism and disposition (01.10.2014)
Published in Drug metabolism and disposition (01.10.2014)
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Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans
Ryder, Tim F., Bergman, Arthur, King-Ahmad, Amanda, Amin, Neeta B., Lall, Manjinder S., Ballard, T. Eric, Kalgutkar, Amit S.
Published in Xenobiotica (04.03.2022)
Published in Xenobiotica (04.03.2022)
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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Ryder, Tim F, Calabrese, Matthew F, Walker, Gregory S, Cameron, Kimberly O, Reyes, Allan R, Borzilleri, Kris A, Delmore, Jake, Miller, Russell, Kurumbail, Ravi G, Ward, Jessica, Kung, Daniel W, Brown, Janice A, Edmonds, David J, Eng, Heather, Wolford, Angela C, Kalgutkar, Amit S
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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In Vitro Metabolism and Covalent Binding of Enol-Carboxamide Derivatives and Anti-Inflammatory Agents Sudoxicam and Meloxicam: Insights into the Hepatotoxicity of Sudoxicam
Obach, R. Scott, Kalgutkar, Amit S, Ryder, Tim F, Walker, Gregory S
Published in Chemical research in toxicology (01.09.2008)
Published in Chemical research in toxicology (01.09.2008)
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Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human
Sharma, Raman, Sun, Hao, Piotrowski, David W, Ryder, Tim F, Doran, Shawn D, Dai, Haiqing, Prakash, Chandra
Published in Drug metabolism and disposition (01.11.2012)
Published in Drug metabolism and disposition (01.11.2012)
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Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human
Sawant-Basak, Aarti, Coffman, Karen J., Walker, Gregory S., Ryder, Tim F., Tseng, Elaine, Miller, Emily, Lee, Carlos, Vanase-Frawley, Michelle A., Wong, John W., Brodney, Michael A., Rapp, Tracey, Obach, R. Scott
Published in Journal of pharmaceutical sciences (01.09.2013)
Published in Journal of pharmaceutical sciences (01.09.2013)
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Journal Article
Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor
Kalgutkar, Amit S, Ryder, Tim F, Walker, Gregory S, Orr, Suvi T M, Cabral, Shawn, Goosen, Theunis C, Lapham, Kimberly, Eng, Heather
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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Journal Article
Species differences in the biotransformation of an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist: the effects of distinct glucuronide metabolites on overall compound disposition
Shaffer, Christopher L, Gunduz, Mithat, Ryder, Tim F, O'Connell, Thomas N
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Journal Article
Acyl Glucuronide Metabolites of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Ryder, Tim F., Calabrese, Matthew F., Walker, Gregory S., Cameron, Kimberly O., Reyes, Allan R., Borzilleri, Kris A., Delmore, Jake, Miller, Russell, Kurumbail, Ravi G., Ward, Jessica, Kung, Daniel W., Brown, Janice A., Edmonds, David J., Eng, Heather, Wolford, Angela C., Kalgutkar, Amit S.
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition
Christopher L. Shaffer, Mithat Gunduz, Tim F. Ryder, Thomas N. O'Connell
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Journal Article
Species Differences in the Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist: The Effects of Distinct Glucuronide Metabolites on Overall Compound Disposition
SHAFFER, Christopher L, GUNDUZ, Mithat, RYDER, Tim F, O'CONNELL, Thomas N
Published in Drug metabolism and disposition (2010)
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Published in Drug metabolism and disposition (2010)
Journal Article
Biotransformation of an α 4 β 2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N -Carbamoyl Glucuronide Metabolite
Shaffer, Christopher L., Ryder, Tim F., Venkatakrishnan, Karthik, Henne, Ilana K., O'Connell, Thomas N.
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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Journal Article
Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne, Thomas N. O'Connell
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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