AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval
Rekić, Dinko, Azarov, Ivan, Knöchel, Jane, Sokolov, Victor, Nilsson, Catarina, Wernevik, Linda, Han, David, Rydén‐Bergsten, Tina, Ebrahimi, Ahmad, Dota, Corina, Carlsson, Björn
Published in British journal of clinical pharmacology (01.11.2022)
Published in British journal of clinical pharmacology (01.11.2022)
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Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide
Clewe, Oskar, Rekić, Dinko, Quartino, Angelica L., Carlsson, Björn, Higashimori, Mitsuo, Wernevik, Linda, Hofherr, Alexis, Rydén‐Bergsten, Tina, Nilsson, Catarina, Knöchel, Jane
Published in British journal of clinical pharmacology (01.06.2024)
Published in British journal of clinical pharmacology (01.06.2024)
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Effect of Tenapanor on Interdialytic Weight Gain in Patients on Hemodialysis
Block, Geoffrey A, Rosenbaum, David P, Leonsson-Zachrisson, Maria, Stefansson, Bergur V, Rydén-Bergsten, Tina, Greasley, Peter J, Johansson, Susanne A, Knutsson, Mikael, Carlsson, Björn C
Published in Clinical journal of the American Society of Nephrology (07.09.2016)
Published in Clinical journal of the American Society of Nephrology (07.09.2016)
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An oral antisense oligonucleotide for PCSK9 inhibition
Gennemark, Peter, Walter, Katrin, Clemmensen, Niclas, Rekić, Dinko, Nilsson, Catarina A M, Knöchel, Jane, Hölttä, Mikko, Wernevik, Linda, Rosengren, Birgitta, Kakol-Palm, Dorota, Wang, Yanfeng, Yu, Rosie Z, Geary, Richard S, Riney, Stan J, Monia, Brett P, Isaksson, Rikard, Jansson-Löfmark, Rasmus, Rocha, Cristina S J, Lindén, Daniel, Hurt-Camejo, Eva, Crooke, Rosanne, Tillman, Lloyd, Rydén-Bergsten, Tina, Carlsson, Björn, Andersson, Ulf, Elebring, Marie, Tivesten, Anna, Davies, Nigel
Published in Science translational medicine (12.05.2021)
Published in Science translational medicine (12.05.2021)
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Inhibition of the prostaglandin D2–GPR44/DP2 axis improves human islet survival and function
Abadpour, Shadab, Tyrberg, Björn, Schive, Simen W., Huldt, Charlotte Wennberg, Gennemark, Peter, Ryberg, Erik, Rydén-Bergsten, Tina, Smith, David M., Korsgren, Olle, Skrtic, Stanko, Scholz, Hanne, Winzell, Maria Sörhede
Published in Diabetologia (01.07.2020)
Published in Diabetologia (01.07.2020)
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Inhibition of the prostaglandin D 2 -GPR44/DP2 axis improves human islet survival and function
Abadpour, Shadab, Tyrberg, Björn, Schive, Simen W, Huldt, Charlotte Wennberg, Gennemark, Peter, Ryberg, Erik, Rydén-Bergsten, Tina, Smith, David M, Korsgren, Olle, Skrtic, Stanko, Scholz, Hanne, Winzell, Maria Sörhede
Published in Diabetologia (2020)
Published in Diabetologia (2020)
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A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II
Knöchel, Jane, Nilsson, Catarina, Carlsson, Björn, Wernevik, Linda, Hofherr, Alexis, Gennemark, Peter, Jansson‐Löfmark, Rasmus, Isaksson, Rikard, Rydén‐Bergsten, Tina, Hamrén, Bengt, Rekić, Dinko
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
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Satisfaction with glucose-lowering treatment and well-being in patients with type 2 diabetes and myocardial infarction: A DIGAMI2 QoL sub-study
Venskutonyte, Laura, Brismar, Kerstin, Rydén-Bergsten, Tina, Rydén, Lars, Kjellström, Barbro
Published in Diabetes & vascular disease research (01.05.2013)
Published in Diabetes & vascular disease research (01.05.2013)
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Abstract 11482: The PCSK9-Targeted Antisense Oligonucleotide AZD8233 Reduces LDL-C, ApoB, and Lp(a) in Patients With Dyslipidemia on Statin Treatment - Data From the Phase 2b ETESIAN Study
Hofherr, Alexis, Schumi, Jennifer, Rudvik, Anna, Vega, Rick, Ryden-Bergsten, Tina, Hurt-Camejo, Eva, Johanson, Per, Carlsson, Bjorn C
Published in Circulation (New York, N.Y.) (08.11.2022)
Published in Circulation (New York, N.Y.) (08.11.2022)
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Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients
Skrtic, Stanko, Tyrberg, Björn, Broberg, Malin, Ericsson, Hans, Schnecke, Volker, Kjaer, Magnus, Hompesch, Marcus, Andersson, Eva-Marie, Ryberg, Erik, Aivazidis, Alexander, Wennberg Huldt, Charlotte, Löfgren, Lars, Morrow, Linda, Parkinson, Joanna, Rydén-Bergsten, Tina, Watkins, Elaine, Sörhede Winzell, Maria
Published in PloS one (2018)
Published in PloS one (2018)
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ETESIAN: A PHASE 2B STUDY OF THE EFFICACY, SAFETY AND TOLERABILITY OF AZD8233, A PCSK9-TARGETED ANTISENSE OLIGONUCLEOTIDE, IN PATIENTS WITH DYSLIPIDEMIA
Koren, Michael J., Hofherr, Alexis, Schumi, Jennifer, Rekic, Dinko, Knochel, Jane, Nilsson, Catarina A.M., Rudvik, Anna, Wernevik, Linda, Ryden-Bergsten, Tina, Carlsson, Bjorn C.L.
Published in Journal of the American College of Cardiology (01.03.2022)
Published in Journal of the American College of Cardiology (01.03.2022)
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Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability
King, Andrew J, Siegel, Matthew, He, Ying, Nie, Baoming, Wang, Ji, Koo-McCoy, Samantha, Minassian, Natali A, Jafri, Qumber, Pan, Deng, Kohler, Jill, Kumaraswamy, Padmapriya, Kozuka, Kenji, Lewis, Jason G, Dragoli, Dean, Rosenbaum, David P, O'Neill, Debbie, Plain, Allein, Greasley, Peter J, Jönsson-Rylander, Ann-Cathrine, Karlsson, Daniel, Behrendt, Margareta, Strömstedt, Maria, Ryden-Bergsten, Tina, Knöpfel, Thomas, Pastor Arroyo, Eva M, Hernando, Nati, Marks, Joanne, Donowitz, Mark, Wagner, Carsten A, Alexander, R Todd, Caldwell, Jeremy S
Published in Science translational medicine (29.08.2018)
Published in Science translational medicine (29.08.2018)
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IL-33 as a Novel Target for the Treatment of Diabetic Kidney Disease: PO0645
Musial, Barbara, Seth, Asha, Baker, David J., Heasman, Stephanie C., Conway, James, Slidel, Tim, Wang, Xiaozhen J., Ryden-Bergsten, Tina, Laerkegaard Hansen, Pernille B., Woollard, Kevin, Marin, Elena Liarte
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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Exploring the insulin secretory properties of the PGD(2)-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients
Skrtic, Stanko, Tyrberg, B., Broberg, M., Ericsson, H., Schnecke, V., Kjaer, M., Hompesch, M., Andersson, E. M., Ryberg, E., Aivazidis, A., Huldt, C. W., Lofgren, L., Morrow, L., Parkinson, J., Ryden-Bergsten, T., Watkins, E., Winzell, M. S.
Published in PloS one (17.12.2018)
Published in PloS one (17.12.2018)
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Exploring the insulin secretory properties of the PGD.sub.2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients
Skrtic, Stanko, Tyrberg, Björn, Broberg, Malin, Ericsson, Hans, Schnecke, Volker, Kjaer, Magnus, Hompesch, Marcus, Andersson, Eva-Marie, Ryberg, Erik, Aivazidis, Alexander, Wennberg Huldt, Charlotte, Löfgren, Lars, Morrow, Linda, Parkinson, Joanna, Rydén-Bergsten, Tina, Watkins, Elaine, Sörhede Winzell, Maria
Published in PloS one (17.12.2018)
Published in PloS one (17.12.2018)
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