Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A., Hannan, Ross D.
Published in Cancer cell (10.07.2012)
Published in Cancer cell (10.07.2012)
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Journal Article
CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy
Siddiqui-Jain, Adam, Drygin, Denis, Streiner, Nicole, Chua, Peter, Pierre, Fabrice, O'Brien, Sean E, Bliesath, Josh, Omori, Mayuko, Huser, Nanni, Ho, Caroline, Proffitt, Chris, Schwaebe, Michael K, Ryckman, David M, Rice, William G, Anderes, Kenna
Published in Cancer research (Chicago, Ill.) (15.12.2010)
Published in Cancer research (Chicago, Ill.) (15.12.2010)
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Journal Article
Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy
Drygin, Denis, Haddach, Mustapha, Pierre, Fabrice, Ryckman, David M
Published in Journal of medicinal chemistry (11.10.2012)
Published in Journal of medicinal chemistry (11.10.2012)
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Journal Article
Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer
Pierre, Fabrice, Chua, Peter C, O’Brien, Sean E, Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K, Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P, Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Anderes, Kenna, Bliesath, Josh, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Trent, Katy, Rice, William G, Ryckman, David M
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Journal Article
Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer
Battistutta, Roberto, Cozza, Giorgio, Pierre, Fabrice, Papinutto, Elena, Lolli, Graziano, Sarno, Stefania, O’Brien, Sean E, Siddiqui-Jain, Adam, Haddach, Mustapha, Anderes, Kenna, Ryckman, David M, Meggio, Flavio, Pinna, Lorenzo A
Published in Biochemistry (Easton) (04.10.2011)
Published in Biochemistry (Easton) (04.10.2011)
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Journal Article
CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy
Siddiqui-Jain, Adam, Bliesath, Joshua, Macalino, Diwata, Omori, Mayuko, Huser, Nanni, Streiner, Nicole, Ho, Caroline B, Anderes, Kenna, Proffitt, Chris, O'Brien, Sean E, Lim, John K C, Von Hoff, Daniel D, Ryckman, David M, Rice, William G, Drygin, Denis
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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Journal Article
Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
Pierre, Fabrice, Chua, Peter C., O’Brien, Sean E., Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K., Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P., Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Bliesath, Joshua, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Rice, William G., Ryckman, David M., Anderes, Kenna
Published in Molecular and cellular biochemistry (01.10.2011)
Published in Molecular and cellular biochemistry (01.10.2011)
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Journal Article
Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells
Bliesath, Joshua, Huser, Nanni, Omori, Mayuko, Bunag, Daniel, Proffitt, Chris, Streiner, Nicole, Ho, Caroline, Siddiqui-Jain, Adam, O’Brien, Sean E, Lim, John K.C, Ryckman, David M, Anderes, Kenna, Rice, William G, Drygin, Denis
Published in Cancer letters (01.09.2012)
Published in Cancer letters (01.09.2012)
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Journal Article
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
Haddach, Mustapha, Schwaebe, Michael K, Michaux, Jerome, Nagasawa, Johnny, O'Brien, Sean E, Whitten, Jeffrey P, Pierre, Fabrice, Kerdoncuff, Pauline, Darjania, Levan, Stansfield, Ryan, Drygin, Denis, Anderes, Kenna, Proffitt, Chris, Bliesath, Josh, Siddiqui-Jain, Adam, Omori, May, Huser, Nanni, Rice, William G, Ryckman, David M
Published in ACS medicinal chemistry letters (12.07.2012)
Published in ACS medicinal chemistry letters (12.07.2012)
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Journal Article
Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer
Drygin, Denis, Ho, Caroline B., Omori, Mayuko, Bliesath, Joshua, Proffitt, Chris, Rice, Rachel, Siddiqui-Jain, Adam, O’Brien, Sean, Padgett, Claire, Lim, John K.C., Anderes, Kenna, Rice, William G., Ryckman, David
Published in Biochemical and biophysical research communications (11.11.2011)
Published in Biochemical and biophysical research communications (11.11.2011)
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Journal Article
7-(4 H-1,2,4-Triazol-3-yl)benzo[ c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity
Pierre, Fabrice, Stefan, Eric, Nédellec, Anne-Sophie, Chevrel, Marie-Claire, Regan, Collin F., Siddiqui-Jain, Adam, Macalino, Diwata, Streiner, Nicole, Drygin, Denis, Haddach, Mustapha, O’Brien, Sean E., Anderes, Kenna, Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor
Haddach, Mustapha, Michaux, Jerome, Schwaebe, Michael K, Pierre, Fabrice, O’Brien, Sean E, Borsan, Cosmin, Tran, Joe, Raffaele, Nicholas, Ravula, Suchitra, Drygin, Denis, Siddiqui-Jain, Adam, Darjania, Levan, Stansfield, Ryan, Proffitt, Chris, Macalino, Diwata, Streiner, Nicole, Bliesath, Joshua, Omori, May, Whitten, Jeffrey P, Anderes, Kenna, Rice, William G, Ryckman, David M
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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Journal Article
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
Pierre, Fabrice, Regan, Collin F., Chevrel, Marie-Claire, Siddiqui-Jain, Adam, Macalino, Diwata, Streiner, Nicole, Drygin, Denis, Haddach, Mustapha, O’Brien, Sean E., Rice, William G., Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
A Facile Synthesis of 5-Halopyrimidine-4-Carboxylic Acid Esters via a Minisci Reaction
Regan, Collin F., Pierre, Fabrice, Schwaebe, Michael K., Haddach, Mustapha, Jung, Michael E., Ryckman, David M.
Published in Synlett (01.02.2012)
Published in Synlett (01.02.2012)
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Journal Article
Novel potent pyrimido[4,5- c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties
Pierre, Fabrice, O’Brien, Sean E., Haddach, Mustapha, Bourbon, Pauline, Schwaebe, Michael K., Stefan, Eric, Darjania, Levan, Stansfield, Ryan, Ho, Caroline, Siddiqui-Jain, Adam, Streiner, Nicole, Rice, William G., Anderes, Kenna, Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs
Haddach, Mustapha, Pierre, Fabrice, Regan, Collin F., Borsan, Cosmin, Michaux, Jerome, Stefan, Eric, Kerdoncuff, Pauline, Schwaebe, Michael K., Chua, Peter C., Siddiqui-Jain, Adam, Macalino, Diwata, Drygin, Denis, O’Brien, Sean E., Rice, William G., Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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