Stabilizing the closed SARS-CoV-2 spike trimer
Juraszek, Jarek, Rutten, Lucy, Blokland, Sven, Bouchier, Pascale, Voorzaat, Richard, Ritschel, Tina, Bakkers, Mark J G, Renault, Ludovic L R, Langedijk, Johannes P M
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses
Bos, Rinke, Rutten, Lucy, van der Lubbe, Joan E. M., Bakkers, Mark J. G., Hardenberg, Gijs, Wegmann, Frank, Zuijdgeest, David, de Wilde, Adriaan H., Koornneef, Annemart, Verwilligen, Annemiek, van Manen, Danielle, Kwaks, Ted, Vogels, Ronald, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Li, Zhenfeng, Barouch, Dan H., Vellinga, Jort, Langedijk, Johannes P. M., Zahn, Roland C., Custers, Jerome, Schuitemaker, Hanneke
Published in npj vaccines (28.09.2020)
Published in npj vaccines (28.09.2020)
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Journal Article
A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers
Rutten, Lucy, Lai, Yen-Ting, Blokland, Sven, Truan, Daphne, Bisschop, Ilona J.M., Strokappe, Nika M., Koornneef, Annemart, van Manen, Danielle, Chuang, Gwo-Yu, Farney, S. Katie, Schuitemaker, Hanneke, Kwong, Peter D., Langedijk, Johannes P.M.
Published in Cell reports (Cambridge) (10.04.2018)
Published in Cell reports (Cambridge) (10.04.2018)
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Journal Article
CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits
Koornneef, Annemart, Vanshylla, Kanika, Hardenberg, Gijs, Rutten, Lucy, Strokappe, Nika M, Tolboom, Jeroen, Vreugdenhil, Jessica, Boer, Karin Feddes-de, Perkasa, Aditya, Blokland, Sven, Burger, Judith A, Huang, Wei-Chiao, Lovell, Jonathan F, van Manen, Danielle, Sanders, Rogier W, Zahn, Roland C, Schuitemaker, Hanneke, Langedijk, Johannes P M, Wegmann, Frank
Published in Nature communications (11.04.2024)
Published in Nature communications (11.04.2024)
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Journal Article
Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike
Yu, Xiaodi, Juraszek, Jarek, Rutten, Lucy, Bakkers, Mark J G, Blokland, Sven, Melchers, Jelle M, van den Broek, Niels J F, Verwilligen, Annemiek Y W, Abeywickrema, Pravien, Vingerhoets, Johan, Neefs, Jean-Marc, Bakhash, Shah A Mohamed, Roychoudhury, Pavitra, Greninger, Alex, Sharma, Sujata, Langedijk, Johannes P M
Published in PLoS pathogens (01.05.2023)
Published in PLoS pathogens (01.05.2023)
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Journal Article
Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity
Rutten, Lucy, Swart, Maarten, Koornneef, Annemart, Bouchier, Pascale, Blokland, Sven, Sadi, Ava, Juraszek, Jarek, Vijayan, Aneesh, Schmit-Tillemans, Sonja, Verspuij, Johan, Choi, Ying, Daal, Chenandly E, Perkasa, Aditya, Torres Morales, Shessy, Myeni, Sebenzile K, Kikkert, Marjolein, Tolboom, Jeroen, van Manen, Daniëlle, Kuipers, Harmjan, Schuitemaker, Hanneke, Zahn, Roland, Langedijk, Johannes P M
Published in Scientific reports (08.03.2024)
Published in Scientific reports (08.03.2024)
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Journal Article
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition
Lutje Hulsik, David, Liu, Ying-ying, Strokappe, Nika M, Battella, Simone, El Khattabi, Mohamed, McCoy, Laura E, Sabin, Charles, Hinz, Andreas, Hock, Miriam, Macheboeuf, Pauline, Bonvin, Alexandre M J J, Langedijk, Johannes P M, Davis, David, Forsman Quigley, Anna, Aasa-Chapman, Marlén M I, Seaman, Michael S, Ramos, Alejandra, Poignard, Pascal, Favier, Adrien, Simorre, Jean-Pierre, Weiss, Robin A, Verrips, C Theo, Weissenhorn, Winfried, Rutten, Lucy
Published in PLoS pathogens (01.03.2013)
Published in PLoS pathogens (01.03.2013)
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Journal Article
Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies
Calpe, Silvia, Wagner, Koen, El Khattabi, Mohamed, Rutten, Lucy, Zimberlin, Cheryl, Dolk, Edward, Verrips, C Theo, Medema, Jan Paul, Spits, Hergen, Krishnadath, Kausilia K
Published in Molecular cancer therapeutics (01.11.2015)
Published in Molecular cancer therapeutics (01.11.2015)
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Journal Article
Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1
McCoy, Laura E, Rutten, Lucy, Frampton, Dan, Anderson, Ian, Granger, Luke, Bashford-Rogers, Rachael, Dekkers, Gillian, Strokappe, Nika M, Seaman, Michael S, Koh, Willie, Grippo, Vanina, Kliche, Alexander, Verrips, Theo, Kellam, Paul, Fassati, Ariberto, Weiss, Robin A
Published in PLoS pathogens (01.12.2014)
Published in PLoS pathogens (01.12.2014)
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Journal Article
Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase
Gover, Sheila, Kotaka, Masayo, Au, Shannon W. N., Lam, Veronica M. S., Vandeputte-Rutten, Lucy, Adams, Margaret J.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2005)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2005)
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Journal Article
Absolute quantitation of binding antibodies from clinical samples
Tang, Chan, Verwilligen, Annemiek, Sadoff, Jerald, Brandenburg, Boerries, Sneekes-Vriese, Eveline, van den Kerkhof, Tom, Dillen, Lieve, Rutten, Lucy, Juraszek, Jarek, Callewaert, Katleen, Janssen, Sarah, Huizingh, Jeroen, Euler, Zelda, Schilperoord, Tom, Verhemeldonck, Marc, Langedijk, Johannes P M, Hendriks, Jenny, Stieh, Daniel J
Published in npj vaccines (06.01.2024)
Published in npj vaccines (06.01.2024)
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Journal Article
Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
Strokappe, Nika M., Hock, Miriam, Rutten, Lucy, Mccoy, Laura E., Back, Jaap W., Caillat, Christophe, Haffke, Matthias, Weiss, Robin A., Weissenhorn, Winfried, Verrips, Theo
Published in Antibodies (Basel) (18.06.2019)
Published in Antibodies (Basel) (18.06.2019)
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Journal Article
Two-Partner Secretion Systems of Neisseria meningitidis Associated with Invasive Clonal Complexes
van Ulsen, Peter, Rutten, Lucy, Feller, Moniek, Tommassen, Jan, van der Ende, Arie
Published in Infection and Immunity (01.10.2008)
Published in Infection and Immunity (01.10.2008)
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Journal Article
Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium
Rutten, Lucy, Mannie, Jean-Paul B.A, Stead, Christopher M, Raetz, Christian R.H, Reynolds, C. Michael, Bonvin, Alexandre M.J.J, Tommassen, Jan P, Egmond, Maarten R, Trent, M. Stephen, Gros, Piet
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
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Journal Article
Crystal Structure and Catalytic Mechanism of the LPS 3-O-Deacylase PagL from Pseudomonas aeruginosa
Rutten, Lucy, Geurtsen, Jeroen, Lambert, Wietske, Smolenaers, Jeroen J. M., Bonvin, Alexandre M., de Haan, Alex, van der Ley, Peter, Egmond, Maarten R., Gros, Piet, Tommassen, Jan
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2006)
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Journal Article
A single amino acid change (Y318F) in the L-arabitol dehydrogenase (LadA) from Aspergillus niger results in a significant increase in affinity for D-sorbitol
Rutten, Lucy, Ribot, Cecile, Trejo-Aguilar, Blanca, Wösten, Han A B, de Vries, Ronald P
Published in BMC microbiology (12.08.2009)
Published in BMC microbiology (12.08.2009)
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Journal Article
Autotransporter secretion: varying on a theme
Grijpstra, Jan, Arenas, Jesús, Rutten, Lucy, Tommassen, Jan
Published in Research in microbiology (01.07.2013)
Published in Research in microbiology (01.07.2013)
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Journal Article
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
Mercado, Noe B, Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H, He, Xuan, Martinez, David R, Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P, Kwaks, Ted, Bakkers, Mark J G, Zuijdgeest, David, Rosendahl Huber, Sietske K, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Bondzie, Esther A, Dagotto, Gabriel, Gebre, Makda S, Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H, Maxfield, Lori F, Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P, Patel, Shivani, Ventura, John D, Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G, Cai, Yongfei, Chen, Bing, Schmidt, Aaron G, Reeves, R Keith, Baric, Ralph S, Lauffenburger, Douglas A, Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, Barouch, Dan H
Published in Nature (London) (22.10.2020)
Published in Nature (London) (22.10.2020)
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