Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue
Wang, Li, Rubadue, Kasi J., Alberts, Jeffrey, Bedwell, David W., Ruterbories, Kenneth J.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.09.2017)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.09.2017)
Get full text
Journal Article
Signature peptide selection workflow for biomarker quantification using LC–MS-based targeted proteomics
Qiu, Xiazi I, Ruterbories, Kenneth J, Ji, Qin C, Jenkins, Gary J
Published in Bioanalysis (01.03.2023)
Published in Bioanalysis (01.03.2023)
Get full text
Journal Article
Comparison of three parallelism assessment methods of biomarker quantification by LC-MS/MS: a case study of the bioanalysis of creatinine in human urine samples
Qiu, Xiazi I, Savaryn, John P, Ruterbories, Kenneth J, Ji, Qin C, Jenkins, Gary
Published in Bioanalysis (01.03.2022)
Published in Bioanalysis (01.03.2022)
Get full text
Journal Article
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates
Rougée, Luc R A, Mohutsky, Michael A, Bedwell, David W, Ruterbories, Kenneth J, Hall, Stephen D
Published in Drug metabolism and disposition (01.09.2017)
Published in Drug metabolism and disposition (01.09.2017)
Get full text
Journal Article
The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
WILLIAMS, Eric T, JONES, Karen O, PONSLER, G. Douglas, LOWERY, Shane M, PERKINS, Everett J, WRIGHTON, Steven A, RUTERBORIES, Kenneth J, KAZUI, Miho, FARID, Nagy A
Published in Drug metabolism and disposition (01.07.2008)
Published in Drug metabolism and disposition (01.07.2008)
Get full text
Journal Article
Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human
WILLIAMS, Eric T, BACON, James A, WRIGHTON, Steven A, PERKINS, Everett J, BENDER, David M, LOWINGER, Jennifer J, GUO, Wen-Kai, EHSANI, Mariam E, XILIANG WANG, HE WANG, QIAN, Yue-Wei, RUTERBORIES, Kenneth J
Published in Drug metabolism and disposition (01.12.2011)
Published in Drug metabolism and disposition (01.12.2011)
Get full text
Journal Article
In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug
Moulton, Richard D, Ruterbories, Kenneth J, Bedwell, David W, Mohutsky, Michael A
Published in Drug metabolism and disposition (01.05.2015)
Published in Drug metabolism and disposition (01.05.2015)
Get full text
Journal Article
Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
Zhou, Xin, Rougée, Luc R A, Bedwell, David W, Cramer, Jeff W, Mohutsky, Michael A, Calvert, Nathan A, Moulton, Richard D, Cassidy, Kenneth C, Yumibe, Nathan P, Adams, Lisa A, Ruterbories, Kenneth J
Published in Drug metabolism and disposition (01.08.2016)
Published in Drug metabolism and disposition (01.08.2016)
Get full text
Journal Article
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates
Rougée, Luc R A, Mohutsky, Michael A, Bedwell, David W, Ruterbories, Kenneth J, Hall, Stephen D
Published in Drug metabolism and disposition (01.11.2016)
Published in Drug metabolism and disposition (01.11.2016)
Get full text
Journal Article
Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs
Zamek-Gliszczynski, Maciej J., Ruterbories, Kenneth J., Ajamie, Rose T., Wickremsinhe, Enaksha R., Pothuri, Lavanya, Rao, Mukkavilli V.S., Basavanakatti, Vinay N., Pinjari, Jakir, Ramanathan, Vikram K., Chaudhary, Ajai K.
Published in Journal of pharmaceutical sciences (01.06.2011)
Published in Journal of pharmaceutical sciences (01.06.2011)
Get full text
Journal Article
High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC–MS/MS
Wickremsinhe, Enaksha R., Lee, Lisa B., Schmalz, Chris A., Torchia, John, Ruterbories, Kenneth J.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.08.2013)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.08.2013)
Get full text
Journal Article
Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7
WILLIAMS, J. Andrew, RING, Barbara J, CANTRELL, Varon E, JONES, David R, ECKSTEIN, James, RUTERBORIES, Kenneth, HAMMAN, Mitchell A, HALL, Stephen D, WRIGHTON, Steven A
Published in Drug metabolism and disposition (01.08.2002)
Published in Drug metabolism and disposition (01.08.2002)
Get full text
Journal Article
Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse
Patel, Nita J, Wickremsinhe, Enaksha, Hui, Yu-Hua, Barr, Alexandar, Masterson, Nicholas, Ruterbories, Kenneth, Weller, Jennifer, Hanes, Jennifer, Kern, Tom, Perkins, Everett
Published in Journal of pharmacy & pharmaceutical sciences (01.10.2016)
Published in Journal of pharmacy & pharmaceutical sciences (01.10.2016)
Get full text
Journal Article
Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
Wickremsinhe, Enaksha R, Tian, Ye, Ruterbories, Kenneth J, Verburg, Elizabeth M, Weerakkody, Govinda J, Kurihara, Atsushi, Farid, Nagy A
Published in Drug metabolism and disposition (01.06.2007)
Published in Drug metabolism and disposition (01.06.2007)
Get full text
Journal Article
Preclinical bridging studies: understanding dried blood spot and plasma exposure profiles
Wickremsinhe, Enaksha R, Huang, Naijia H, Abdul, Basira G, Knotts, Kirk, Ruterbories, Kenneth J, Manro, Jason R
Published in Bioanalysis (01.01.2013)
Published in Bioanalysis (01.01.2013)
Get full text
Journal Article
Dried blood spot sampling: coupling bioanalytical feasibility, blood-plasma partitioning and transferability to in vivo preclinical studies
Wickremsinhe, Enaksha R, Abdul, Basira G, Huang, Naijia H, Richard, John W, Hanes, Jennifer L, Ruterbories, Kenneth J, Perkins, Everett J, Chaudhary, Ajai K
Published in Bioanalysis (01.07.2011)
Published in Bioanalysis (01.07.2011)
Get more information
Journal Article
Analytical method considerations regarding carryover for monophosphate prodrugs for in vivo samples by liquid chromatography-tandem mass spectrometry
Heinle, Lance, Patel, Hardikkumar, Jenkins, Gary, Ruterbories, Kenneth
Published in Journal of Chromatography A (22.11.2019)
Published in Journal of Chromatography A (22.11.2019)
Get full text
Journal Article
A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro
Fayer, Jessica L, Petullo, David M, Ring, Barbara J, Wrighton, Steven A, Ruterbories, Kenneth J
Published in Journal of pharmacological and toxicological methods (01.09.2001)
Published in Journal of pharmacological and toxicological methods (01.09.2001)
Get full text
Journal Article
Correction to: A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice
Varkhede, Ninad, Patel, Nita, Chang, William, Ruterbories, Kenneth, Forrest, M. Laird
Published in Pharmaceutical research (01.09.2018)
Published in Pharmaceutical research (01.09.2018)
Get full text
Journal Article