Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine
Singh, Juswinder, Hagel, Margit, Niu, Deqiang, St Martin, Thia, Sheets, Michael P, Qiao, Lixin, Bernard, Hugues, Karp, Russell M, Zhu, Zhendong, Labenski, Matthew T, Chaturvedi, Prasoon, Nacht, Mariana, Westlin, William F, Petter, Russell C
Published in Nature Chemical Biology (01.01.2011)
Published in Nature Chemical Biology (01.01.2011)
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Journal Article
The resurgence of covalent drugs
Singh, Juswinder, Petter, Russell C, Baillie, Thomas A, Whitty, Adrian
Published in Nature reviews. Drug discovery (01.04.2011)
Published in Nature reviews. Drug discovery (01.04.2011)
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Journal Article
Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines
Krenske, Elizabeth H, Petter, Russell C, Houk, K. N
Published in Journal of organic chemistry (02.12.2016)
Published in Journal of organic chemistry (02.12.2016)
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Journal Article
Targeted covalent drugs of the kinase family
Singh, Juswinder, Petter, Russell C, Kluge, Arthur F
Published in Current opinion in chemical biology (01.08.2010)
Published in Current opinion in chemical biology (01.08.2010)
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Journal Article
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
Walter, Annette O, Sjin, Robert Tjin Tham, Haringsma, Henry J, Ohashi, Kadoaki, Sun, Jing, Lee, Kwangho, Dubrovskiy, Aleksandr, Labenski, Matthew, Zhu, Zhendong, Wang, Zhigang, Sheets, Michael, St Martin, Thia, Karp, Russell, van Kalken, Dan, Chaturvedi, Prasoon, Niu, Deqiang, Nacht, Mariana, Petter, Russell C, Westlin, William, Lin, Kevin, Jaw-Tsai, Sarah, Raponi, Mitch, Van Dyke, Terry, Etter, Jeff, Weaver, Zoe, Pao, William, Singh, Juswinder, Simmons, Andrew D, Harding, Thomas C, Allen, Andrew
Published in Cancer discovery (01.12.2013)
Published in Cancer discovery (01.12.2013)
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Journal Article
Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans
Evans, Erica K, Tester, Richland, Aslanian, Sharon, Karp, Russell, Sheets, Michael, Labenski, Matthew T, Witowski, Steven R, Lounsbury, Heather, Chaturvedi, Prasoon, Mazdiyasni, Hormoz, Zhu, Zhendong, Nacht, Mariana, Freed, Martin I, Petter, Russell C, Dubrovskiy, Alex, Singh, Juswinder, Westlin, William F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
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Journal Article
Transition States and Energetics of Nucleophilic Additions of Thiols to Substituted α,β-Unsaturated Ketones: Substituent Effects Involve Enone Stabilization, Product Branching, and Solvation
Krenske, Elizabeth H, Petter, Russell C, Zhu, Zhendong, Houk, K. N
Published in Journal of organic chemistry (17.06.2011)
Published in Journal of organic chemistry (17.06.2011)
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Journal Article
Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase PI3Kα
Nacht, Mariana, Qiao, Lixin, Sheets, Michael P, St. Martin, Thia, Labenski, Matthew, Mazdiyasni, Hormoz, Karp, Russell, Zhu, Zhendong, Chaturvedi, Prasoon, Bhavsar, Deepa, Niu, Deqiang, Westlin, William, Petter, Russell C, Medikonda, Aravind Prasad, Singh, Juswinder
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing
Tjin Tham Sjin, Robert, Lee, Kwangho, Walter, Annette O, Dubrovskiy, Aleksandr, Sheets, Michael, Martin, Thia St, Labenski, Matthew T, Zhu, Zhendong, Tester, Richland, Karp, Russell, Medikonda, Aravind, Chaturvedi, Prasoon, Ren, Yixuan, Haringsma, Henry, Etter, Jeff, Raponi, Mitch, Simmons, Andrew D, Harding, Thomas C, Niu, Deqiang, Nacht, Mariana, Westlin, William F, Petter, Russell C, Allen, Andrew, Singh, Juswinder
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Journal Article
CNS Anticancer Drug Discovery and Development Conference White Paper
Levin, Victor A, Tonge, Peter J, Gallo, James M, Birtwistle, Marc R, Dar, Arvin C, Iavarone, Antonio, Paddison, Patrick J, Heffron, Timothy P, Elmquist, William F, Lachowicz, Jean E, Johnson, Ted W, White, Forest M, Sul, Joohee, Smith, Quentin R, Shen, Wang, Sarkaria, Jann N, Samala, Ramakrishna, Wen, Patrick Y, Berry, Donald A, Petter, Russell C
Published in Neuro-oncology (01.11.2015)
Published in Neuro-oncology (01.11.2015)
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Conference Proceeding
Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists
Vu, Chi B, Kiesman, William F, Conlon, Patrick R, Lin, Ko-Chung, Tam, Melissa, Petter, Russell C, Smits, Glenn, Lutterodt, Frank, Jin, Xiaowei, Chen, Liqing, Zhang, Jianbo
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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N-Terminally PEGylated Human Interferon-β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model
Baker, Darren P, Lin, Edward Y, Lin, KoChung, Pellegrini, Maria, Petter, Russell C, Chen, Ling Ling, Arduini, Robert M, Brickelmaier, Margot, Wen, Dingyi, Hess, Donna M, Chen, Liqing, Grant, Donna, Whitty, Adrian, Gill, Alan, Lindner, Daniel J, Pepinsky, R. Blake
Published in Bioconjugate chemistry (18.01.2006)
Published in Bioconjugate chemistry (18.01.2006)
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Journal Article
Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists
YAO, Gang, HAQUE, Serajul, PETTER, Russell C, LI SHA, KUMARAVEL, Gnanasambandam, WANG, Joy, ENGBER, Thomas M, WHALLEY, Eric T, CONLON, Patrick R, HEXI CHANG, KIESMAN, William F
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists
PENG, Hairuo, KUMARAVEL, Gnanasambandam, YAO, Gang, SHA, Li, WANG, Joy, VAN VLIJMEN, Herman, BOHNERT, Tonika, HUANG, Carol, VU, Chi B., ENSINGER, Carol L., CHANG, Hexi, ENGBER, Thomas M., WHALLEY, Eric T., PETTER, Russell C.
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
Potent and Orally Bioavailable 8-Bicyclo[2.2.2]octylxanthines as Adenosine A1 Receptor Antagonists
Kiesman, William F, Zhao, Jin, Conlon, Patrick R, Dowling, James E, Petter, Russell C, Lutterodt, Frank, Jin, Xiaowei, Smits, Glenn, Fure, Mary, Jayaraj, Andrew, Kim, John, Sullivan, Gail, Linden, Joel
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Journal Article
Novel Diamino Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists
Vu, Chi B, Pan, Deborah, Peng, Bo, Kumaravel, Gnanasambandam, Smits, Glenn, Jin, Xiaowei, Phadke, Deepali, Engber, Thomas, Huang, Carol, Reilly, Jennifer, Tam, Stacy, Grant, Donna, Hetu, Gregg, Petter, Russell C
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Piperazine Derivatives of [1,2,4]Triazolo[1,5-a][1,3,5]triazine as Potent and Selective Adenosine A2a Receptor Antagonists
VU, Chi B., PENG, Bo, KUMARAVEL, Gnanasambandam, SMITS, Glenn, JIN, Xiaowei, PHADKE, Deepali, ENGBER, Thomas, HUANG, Carol, REILLY, Jennifer, TAM, Stacy, GRANT, Donna, HETU, Gregg, CHEN, Liqing, ZHANG, Jianbo, PETTER, Russell C.
Published in Journal of medicinal chemistry (12.08.2004)
Published in Journal of medicinal chemistry (12.08.2004)
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Journal Article
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists
KIESMAN, William F, JIN ZHAO, CONLON, Patrick R, PETTER, Russell C, XIAOWEI JIN, SMITS, Glenn, LUTTERODT, Frank, SULLIVAN, Gail W, LINDEN, Joel
Published in Bioorganic & medicinal chemistry (01.06.2006)
Published in Bioorganic & medicinal chemistry (01.06.2006)
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