Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
KONECNY, Gottfried E, PEGRAM, Mark D, KEITH, Barry R, GILMER, Tona M, BERGER, Mark, PODRATZ, Karl C, SLAMON, Dennis J, VENKATESAN, Natarajan, FINN, Richard, GUORONG YANG, RAHMEH, Martina, UNTCH, Michael, RUSNAK, David W, SPEHAR, Glenn, MULLIN, Robert J
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
WOOD, Edgar R, TRUESDALE, Anne T, ALLIGOOD, Krystal J, RUSNAK, David W, GILMER, Tona M, SHEWCHUK, Lisa, MCDONALD, Octerloney B, YUAN, Derek, HASSELL, Anne, DICKERSON, Scott H, ELLIS, Byron, PENNISI, Christopher, HORNE, Earnest, LACKEY, Karen
Published in Cancer research (Chicago, Ill.) (15.09.2004)
Published in Cancer research (Chicago, Ill.) (15.09.2004)
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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
Xia, Wenle, Mullin, Robert J, Keith, Barry R, Liu, Lei-Hua, Ma, Hong, Rusnak, David W, Owens, Gary, Alligood, Krystal J, Spector, Neil L
Published in Oncogene (12.09.2002)
Published in Oncogene (12.09.2002)
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Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series
Petrov, Kimberly G., Zhang, Yue-Mei, Carter, Malcolm, Cockerill, G. Stuart, Dickerson, Scott, Gauthier, Cassandra A., Guo, Yu, Mook, Robert A., Rusnak, David W., Walker, Ann L., Wood, Edgar R., Lackey, Karen E.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580
James G. Conway, McDonald, Brad, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Jansen, Marilyn, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, James, Ian, Karen Fuller, Timothy J. Chambers, Kull, Frederick C., Stanley D. Chamberlain, Hutchins, Jeff T., Schlessinger, Joseph
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2005)
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Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles
Hegde, Priti S, Rusnak, David, Bertiaux, Melissa, Alligood, Krystal, Strum, Jay, Gagnon, Robert, Gilmer, Tona M
Published in Molecular cancer therapeutics (01.05.2007)
Published in Molecular cancer therapeutics (01.05.2007)
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Journal Article
Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors
Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib
GILMER, Tona M, CABLE, Louann, WOOD, Edgar R, ALLIGOOD, Krystal, RUSNAK, David, SPEHAR, Glenn, GALLAGHER, Kathleen T, WOLDU, Ermias, CARTER, H. Luke, TRUESDALE, Anne T, SHEWCHUK, Lisa
Published in Cancer research (Chicago, Ill.) (15.01.2008)
Published in Cancer research (Chicago, Ill.) (15.01.2008)
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Journal Article
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors
Waterson, Alex G., Petrov, Kimberly G., Hornberger, Keith R., Hubbard, Robert D., Sammond, Douglas M., Smith, Stephon C., Dickson, Hamilton D., Caferro, Thomas R., Hinkle, Kevin W., Stevens, Kirk L., Dickerson, Scott H., Rusnak, David W., Spehar, Glenn M., Wood, Edgar R., Griffin, Robert J., Uehling, David E.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines
Hubbard, Robert D., Dickerson, Scott H., Emerson, Holly K., Griffin, Robert J., Reno, Michael J., Hornberger, Keith R., Rusnak, David W., Wood, Edgar R., Uehling, David E., Waterson, Alex G.
Published in Bioorganic & medicinal chemistry (01.11.2008)
Published in Bioorganic & medicinal chemistry (01.11.2008)
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Journal Article
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
KING, Alastair J, PATRICK, Denis R, HUGGER, Erin, LIFU WANG, KARRETH, Florian, LOUGHEED, Julie C, LEE, Jae, CHAU, David, STOUT, Thomas J, MAY, Earl W, ROMINGER, Cynthia M, SCHABER, Michael D, BATORSKY, Roberta S, LUSONG LUO, LAKDAWALA, Ami S, ADAMS, Jerry L, CONTRACTOR, Rooja G, SMALLEY, Keiran S. M, HERLYN, Meenhard, MORRISSEY, Michael M, TUVESON, David A, HUANG, Pearl S, HO, Maureen L, DO, Hieu T, SHU YUN ZHANG, KUMAR, Rakesh, RUSNAK, David W, TAKLE, Andrew K, WILSON, David M
Published in Cancer research (Chicago, Ill.) (01.12.2006)
Published in Cancer research (Chicago, Ill.) (01.12.2006)
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo
Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M
Published in Molecular cancer therapeutics (01.12.2001)
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Published in Molecular cancer therapeutics (01.12.2001)
Journal Article
Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines
Greshock, Joel, Cheng, Jie, Rusnak, David, Martin, Anne Marie, Wooster, Richard, Gilmer, Tona, Lee, Kwan, Weber, Barbara L, Zaks, Tal
Published in Molecular cancer therapeutics (01.04.2008)
Published in Molecular cancer therapeutics (01.04.2008)
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Journal Article
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors
Waterson, Alex G., Stevens, Kirk L., Reno, Michael J., Zhang, Yue-Mei, Boros, Eric E., Bouvier, Frederic, Rastagar, Abdullah, Uehling, David E., Dickerson, Scott H., Reep, Bryan, McDonald, Octerloney B., Wood, Edgar R., Rusnak, David W., Alligood, Krystal J., Rudolph, Sharon K.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines
Gaul, Micheal D, Guo, Yu, Affleck, Karen, Cockerill, G.Stuart, Gilmer, Tona M, Griffin, Robert J, Guntrip, Stephen, Keith, Barry R, Knight, Wilson B, Mullin, Robert J, Murray, Doris M, Rusnak, David W, Smith, Kathryn, Tadepalli, Sarva, Wood, Edgar R, Lackey, Karen
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assays
RUSNAK, David W, ZHIHONG LAI, LANSING, Timothy J, RHODES, Nelson, GILMER, Tona M, COPELAND, Robert A
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Cloud security in a bioanalytical world: considerations for use of third-party cloud services for bioanalysis
Davis, Scott, Mitra-Kaushik, Shibani, Woolf, Eric, Evens, John, Dawes, Michelle, Kentner, Jason, Subbarao, Nanda, Sundman, Phillip, Rusnak, David
Published in Bioanalysis (01.12.2023)
Published in Bioanalysis (01.12.2023)
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Journal Article
A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)
Wood, Edgar R., Truesdale, Anne T., McDonald, Octerloney B., Yuan, Derek, Hassell, Anne, Dickerson, Scott H., Ellis, Byron, Pennisi, Christopher, Horne, Earnest, Lackey, Karen, Alligood, Krystal J., Rusnak, David W., Gilmer, Tona M., Shewchuk, Lisa
Published in Cancer research (Chicago, Ill.) (15.09.2004)
Published in Cancer research (Chicago, Ill.) (15.09.2004)
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