Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer
Ganson, Nancy J., PhD, Povsic, Thomas J., MD, Sullenger, Bruce A., PhD, Alexander, John H., MD, Zelenkofske, Steven L., DO, Sailstad, Jeffrey M., PhD, Rusconi, Christopher P., PhD, Hershfield, Michael S., MD
Published in Journal of allergy and clinical immunology (01.05.2016)
Published in Journal of allergy and clinical immunology (01.05.2016)
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Journal Article
Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer
Povsic, Thomas J., MD, PhD, Lawrence, Monica G., MD, Lincoff, A. Michael, MD, Mehran, Roxana, MD, Rusconi, Christopher P., PhD, Zelenkofske, Steven L., DO, Huang, Zhen, MS, Sailstad, Jeffrey, BS, Armstrong, Paul W., MD, Steg, P. Gabriel, MD, Bode, Christoph, MD, Becker, Richard C., MD, Alexander, John H., MD, MHS, Adkinson, N. Franklin, MD, Levinson, Arnold I., MD
Published in Journal of allergy and clinical immunology (01.12.2016)
Published in Journal of allergy and clinical immunology (01.12.2016)
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Journal Article
Aptamers: an emerging class of therapeutics
Nimjee, Shahid M, Rusconi, Christopher P, Sullenger, Bruce A
Published in Annual review of medicine (01.01.2005)
Published in Annual review of medicine (01.01.2005)
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Journal Article
Antidote-mediated control of an anticoagulant aptamer in vivo
Rusconi, Christopher P, Sullenger, Bruce A, Roberts, Joseph D, Pitoc, George A, Nimjee, Shahid M, White, Rebekah R, Quick, George, Scardino, Elizabeth, Fay, William P
Published in Nature biotechnology (01.11.2004)
Published in Nature biotechnology (01.11.2004)
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Journal Article
First Clinical Application of an Actively Reversible Direct Factor IXa Inhibitor as an Anticoagulation Strategy in Patients Undergoing Percutaneous Coronary Intervention
COHEN, Mauricio G, PURDY, Drew A, ZELENKOFSKE, Steven, ALEXANDER, John H, HARRINGTON, Robert A, RUSCONI, Christopher P, BECKER, Richard C, ROSSI, Joseph S, GRINFELD, Liliana R, MYLES, Shelley K, ABERLE, Laura H, GREENBAUM, Adam B, FRY, Edward, CHAN, Mark Y, TONKENS, Ross M
Published in Circulation (New York, N.Y.) (10.08.2010)
Published in Circulation (New York, N.Y.) (10.08.2010)
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Journal Article
Factor IXa Inhibitors as Novel Anticoagulants
Howard, Emily L, Becker, Kristian C.D, Rusconi, Christopher P, Becker, Richard C
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2007)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2007)
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Journal Article
An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase
Buddai, Sai K., Layzer, Juliana M., Lu, Genmin, Rusconi, Christopher P., Sullenger, Bruce A., Monroe, Dougald M., Krishnaswamy, Sriram
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Journal Article
Inhibition of Rat Corneal Angiogenesis by a Nuclease-Resistant RNA Aptamer Specific for Angiopoietin-2
White, Rebekah R., Shan, Siqing, Rusconi, Christopher P., Shetty, Geetha, Dewhirst, Mark W., Kontos, Christopher D., Sullenger, Bruce A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
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Journal Article
A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial
Povsic, Thomas J., MD, PhD, Cohen, Mauricio G., MD, Mehran, Roxana, MD, Buller, Christopher E., MD, Bode, Christoph, MD, Cornel, Jan H., MD, Kasprzak, Jarosław D., MD, Montalescot, Gilles, MD, Joseph, Diane, Wargin, William A., PhD, Rusconi, Christopher P., PhD, Zelenkofske, Steven L., DO, Becker, Richard C., MD, Alexander, John H., MD, MHS
Published in The American heart journal (01.02.2011)
Published in The American heart journal (01.02.2011)
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Journal Article
To PEGylate or Not To PEGylate Therapeutics?
Maier, Keith E, Rusconi, Christopher P, Levy, Matthew
Published in Cell chemical biology (16.05.2019)
Published in Cell chemical biology (16.05.2019)
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Journal Article
First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology : A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
DYKE, Christopher K, STEINHUBL, Steven R, BECKER, Richard C, RUSCONI, Christopher P, KLEIMAN, Neal S, CANNON, Richard O, ABERLE, Laura G, MIN LIN, MYLES, Shelley K, MELLONI, Chiara, HARRINGTON, Robert A, ALEXANDER, John H
Published in Circulation (New York, N.Y.) (05.12.2006)
Published in Circulation (New York, N.Y.) (05.12.2006)
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Journal Article
RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins
Jeter, Martha L, Ly, Linda V, Fortenberry, Yolanda M, Whinna, Herbert C, White, Rebekah R, Rusconi, Christopher P, Sullenger, Bruce A, Church, Frank C
Published in FEBS letters (18.06.2004)
Published in FEBS letters (18.06.2004)
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Journal Article
Blocking the initiation of coagulation by RNA aptamers to factor VIIa
Rusconi, C P, Yeh, A, Lyerly, H K, Lawson, J H, Sullenger, B A
Published in Thrombosis and haemostasis (01.11.2000)
Published in Thrombosis and haemostasis (01.11.2000)
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Journal Article
Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease
CHAN, Mark Y, COHEN, Mauricio G, VORCHHEIMER, David A, CHRONOS, Nicholas, MELLONI, Chiara, ALEXANDER, John H, HARRINGTON, Robert A, TONKENS, Ross M, BECKER, Richard C, RUSCONI, Christopher P, DYKE, Christopher K, MYLES, Shelley K, ABERLE, Laura G, MIN LIN, WALDER, James, STEINHUBL, Steven R, GILCHRIST, Ian C, KLEIMAN, Neal S
Published in Circulation (New York, N.Y.) (03.06.2008)
Published in Circulation (New York, N.Y.) (03.06.2008)
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Journal Article
Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes
Staudacher, Dawid L, Putz, Vera, Heger, Lukas, Reinöhl, Jochen, Hortmann, Marcus, Zelenkofske, Steven L, Becker, Richard C, Rusconi, Christopher P, Bode, Christoph, Ahrens, Ingo
Published in European heart journal. Acute cardiovascular care (01.09.2019)
Published in European heart journal. Acute cardiovascular care (01.09.2019)
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Journal Article
Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy
Povsic, Thomas J., Wargin, William A., Alexander, John H., Krasnow, Joshua, Krolick, Merill, Cohen, Mauricio G., Mehran, Roxana, Buller, Christopher E., Bode, Christoph, Zelenkofske, Steven L., Rusconi, Christopher P., Becker, Richard C.
Published in European heart journal (01.10.2011)
Published in European heart journal (01.10.2011)
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Journal Article
The potential of aptamers as anticoagulants
Nimjee, Shahid M., Rusconi, Christopher P., Harrington, Robert A., Sullenger, Bruce A.
Published in Trends in cardiovascular medicine (2005)
Published in Trends in cardiovascular medicine (2005)
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