Molecular insights into lipid-assisted Ca 2+ regulation of the TRP channel Polycystin-2
Wilkes, Martin, Madej, M Gregor, Kreuter, Lydia, Rhinow, Daniel, Heinz, Veronika, De Sanctis, Silvia, Ruppel, Sabine, Richter, Rebecca M, Joos, Friederike, Grieben, Marina, Pike, Ashley C W, Huiskonen, Juha T, Carpenter, Elisabeth P, Kühlbrandt, Werner, Witzgall, Ralph, Ziegler, Christine
Published in Nature structural & molecular biology (01.02.2017)
Published in Nature structural & molecular biology (01.02.2017)
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Journal Article
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
Wilkes, Martin, Madej, M Gregor, Kreuter, Lydia, Rhinow, Daniel, Heinz, Veronika, De Sanctis, Silvia, Ruppel, Sabine, Richter, Rebecca M, Joos, Friederike, Grieben, Marina, Pike, Ashley C W, Huiskonen, Juha T, Carpenter, Elisabeth P, Kühlbrandt, Werner, Witzgall, Ralph, Ziegler, Christine
Published in Nature structural & molecular biology (01.02.2017)
Published in Nature structural & molecular biology (01.02.2017)
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Journal Article
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists
Irwin, Sean, Karr, Craig, Furman, Craig, Tsai, Jennifer, Gee, Patricia, Banka, Deepti, Wibowo, Ardian S., Dementiev, Alexey A., O’Shea, Morgan, Yang, Joyce, Lowe, Jason, Mitchell, Lorna, Ruppel, Sabine, Fekkes, Peter, Zhu, Ping, Korpal, Manav, Larsen, Nicholas A.
Published in The Journal of biological chemistry (01.11.2022)
Published in The Journal of biological chemistry (01.11.2022)
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Journal Article
MEK 억제제 및 이의 용도
PROUDFOOT JOHN, RUPPEL SABINE K, WYNN THOMAS A, BURKE MICHAEL J, CASTRO ALFREDO C
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
Patent
Abstract 3296: IK-595, a best-in-class MEK-RAF molecular glue, drives broad and potent anti-tumor activity across RAS-MAPK pathway-altered cancers as a monotherapy and in combination
Haines, Eric, Catterall, Rachel, De Jesus, Victor, Hidalgo, Daniel, Cavanaugh, Jill, Sanchez-Martin, Marta, Manna, Joseph D., Burke, Michael, Li, Bin, Wessel, Sarah R., Yang, Ao, Santillana, Sergio, Ecsedy, Jeffrey, Zhang, X. Michelle, Ruppel, Sabine K.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract B155: IK-595, a best-in-class MEK-RAF complex inhibitor, drives broad and potent anti-tumor activity in RAS/RAF-driven tumors
Haines, Eric, Catterall, Rachel, De Jesus, Victor, Li, Bin, Wessel, Sarah R, Cavanaugh, Jill, Burke, Michael, Manna, Joseph D, Zavidij, Okzana, Yang, Ao, Xu, Lan, Santillana, Sergio, Ecsedy, Jeffrey, Zhang, X. Michelle, Ruppel, Sabine K
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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화합물 및 그의 용도
DENG JING, RUPPEL SABINE K, BRUCELLE FRANCOIS, NETHERTON MATTHEW, VOIGT JOHANNES H, SCHILLER SHAWN E.R, ANTHONY NEVILLE JOHN
Year of Publication 01.11.2022
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Year of Publication 01.11.2022
Patent
Abstract PR10: IK-595, a MEK-RAF complex inhibitor, obviates CRAF mediated resistance resulting in superior RAS/MAPK pathway inhibition and anti-tumor activity in RAS/RAF altered cancers
Haines, Eric, Burke, Michael, Catterall, Rachel, De Jesus, Victor, Li, Bin, Manna, Joseph D., Punkosdy, George, Zavidij, Oksana, Wessel, Sarah R., Werosta, Grace, Cavanaugh, Jill, Newhouse, Sheila, Basavapathruni, Aravind, Xu, Lan, Santillana, Sergio, Zhang, X. Michelle, Ruppel, Sabine K.
Published in Molecular cancer research (01.05.2023)
Published in Molecular cancer research (01.05.2023)
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Journal Article
Abstract A058: Investigating the molecular role of BRD9 in synovial sarcoma
Topal, Salih, Dominici, Claudia, Collins, Michael, Lahr, David L, Zhou, Qianhe, Uzan, Flore, Mayhew, David, Adam, Ammar, Garbitt-Amaral, Victoria, Antonakos, Brandon, Mikse, Oliver, Ahmad, Hafiz, Parikh, Salonee, Lin, Mei Yun, Wu, Hsin-Jung, Sandoval, Gabriel, Soares, Luis M. M., Muwanguzi, Jordana, Chen, Huawei, Yang, Zhaoxia, Lowe, Jason T., Netherton, Matt, Zawadzke, Laura, Voigt, Johannes, Huang, Liyue, Ruppel, Sabine, Chan, Ho Man, Kruger, Ryan, Millan, David S., Innis, Scott, Bellon, Steven F.
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract A049: Investigation of FHD-609, a potent degrader of BRD9, in preclinical models of acute myeloid leukemia (AML)
Dominici, Claudia, Mayhew, David, Adam, Ammar, Uzan, Flore, Garbitt-Amaral, Victoria, Mikse, Oliver, Antonakos, Brandon, Ahmad, Hafiz, Parikh, Salonee, Lin, Mei Yun, Sandoval, Gabriel, Lahr, David, Wu, Hsin-Jung, Xu, Mengni, Brennan, Sean, Soares, Luis M. M., Muwanguzi, Jordana, Chen, Huawei, Yang, Zhaoxia, Lowe, Jason T, Netherton, Matt, Zawadzke, Laura, Voigt, Johannes, Huang, Liyue, Ruppel, Sabine, Chan, Ho Man, Kruger, Ryan, Milan, David S, Innis, Scott, Zhou, Qianhe, Bellon, Steven F
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
RIPK2의 저해제로서의 헤테로아릴 카복스아미드 화합물
LIU PINGRONG, PADYANA ANIL K, MILLER CRAIG ANDREW, RUPPEL SABINE, ZHANG ZHONGHUA, YU MAOLIN
Year of Publication 07.05.2019
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Year of Publication 07.05.2019
Patent
COMBINATIONS COMPRISING MEK INHIBITORS FOR USE IN THE TREATMENT OF CANCER
CASTRO, Alfredo C, BURKE, Michael J, WYNN, Thomas A, HAINES, Eric, RUPPEL, Sabine K
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
Patent
BRD9 DEGRADERS AND USES THEREOF
NETHERTON, Matthew, BRUCELLE, Francois, YANG, Zhaoxia, LOWE, Jason T, RUPPEL, Sabine K, VOIGT, Johannes H
Year of Publication 09.05.2024
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Year of Publication 09.05.2024
Patent
COMPOUNDS AND USES THEREOF
NETHERTON, Matthew, YANG, Zhaoxia, LOWE, Jason T, RUPPEL, Sabine K, VOIGT, Johannes H
Year of Publication 29.02.2024
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Year of Publication 29.02.2024
Patent
MEK INHIBITORS AND USES THEREOF
CASTRO, Alfredo C, PROUDFOOT, John, BURKE, Michael J, WYNN, Thomas A, RUPPEL, Sabine K
Year of Publication 21.02.2024
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Year of Publication 21.02.2024
Patent