Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)
Hu, Essa, Kunz, Roxanne K, Chen, Ning, Rumfelt, Shannon, Siegmund, Aaron, Andrews, Kristin, Chmait, Samer, Zhao, Sharon, Davis, Carl, Chen, Hang, Lester-Zeiner, Dianna, Ma, Ji, Biorn, Christopher, Shi, Jianxia, Porter, Amy, Treanor, James, Allen, Jennifer R
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors
Hu, Essa, Kunz, Roxanne K., Rumfelt, Shannon, Chen, Ning, Bürli, Roland, Li, Chun, Andrews, Kristin L., Zhang, Jiandong, Chmait, Samer, Kogan, Jeffrey, Lindstrom, Michelle, Hitchcock, Stephen A., Treanor, James
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Initial characterization of a PDE10A selective positron emission tomography tracer [11 C]AMG 7980 in non-human primates
Hwang, Dah-Ren, Hu, Essa, Rumfelt, Shannon, Easwaramoorthy, Balu, Castrillon, John, Davis, Carl, Allen, Jennifer R, Chen, Hang, Treanor, James, Abi-Dargham, Anissa, Slifstein, Mark
Published in Nuclear medicine and biology (01.04.2014)
Published in Nuclear medicine and biology (01.04.2014)
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Journal Article
Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer
Hu, Essa, Ma, Ji, Biorn, Christopher, Lester-Zeiner, Dianna, Cho, Robert, Rumfelt, Shannon, Kunz, Roxanne K, Nixey, Thomas, Michelsen, Klaus, Miller, Silke, Shi, Jianxia, Wong, Jamie, Hill Della Puppa, Geraldine, Able, Jessica, Talreja, Santosh, Hwang, Dah-Ren, Hitchcock, Stephen A, Porter, Amy, Immke, David, Allen, Jennifer R, Treanor, James, Chen, Hang
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
Rzasa, Robert M., Hu, Essa, Rumfelt, Shannon, Chen, Ning, Andrews, Kristin L., Chmait, Samer, Falsey, James R., Zhong, Wenge, Jones, Adrie D., Porter, Amy, Louie, Steven W., Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer
Chen, Hang, Lester-Zeiner, Dianna, Shi, Jianxia, Miller, Silke, Glaus, Charlie, Hu, Essa, Chen, Ning, Able, Jessica, Biorn, Christopher, Wong, Jamie, Ma, Ji, Michelsen, Klaus, Hill Della Puppa, Geraldine, Kazules, Tim, Dou, Hui Hannah, Talreja, Santosh, Zhao, Xiaoning, Chen, Ada, Rumfelt, Shannon, Kunz, Roxanne K, Ye, Hu, Thiel, Oliver R, Williamson, Toni, Davis, Carl, Porter, Amy, Immke, David, Allen, Jennifer R, Treanor, James
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
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Journal Article
Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3)
Hu, Essa, Kunz, Roxanne K., Rumfelt, Shannon, Andrews, Kristin L., Li, Chun, Hitchcock, Stephen A., Lindstrom, Michelle, Treanor, James
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease
Chen, Jian Jeffrey, Qian, Wenyuan, Biswas, Kaustav, Yuan, Chester, Amegadzie, Albert, Liu, Qingyian, Nixey, Thomas, Zhu, Joe, Ncube, Mqhele, Rzasa, Robert M., Chavez, Frank, Chen, Ning, DeMorin, Frenel, Rumfelt, Shannon, Tegley, Christopher M., Allen, Jennifer R., Hitchcock, Stephen, Hungate, Randy, Bartberger, Michael D., Zalameda, Leeanne, Liu, Yichin, McCarter, John D., Zhang, Jianhua, Zhu, Li, Babu-Khan, Safura, Luo, Yi, Bradley, Jodi, Wen, Paul H., Reid, Darren L., Koegler, Frank, Dean, Charles, Hickman, Dean, Correll, Tiffany L., Williamson, Toni, Wood, Stephen
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Journal Article
Discovery of amido-benzisoxazoles as potent c-Kit inhibitors
Kunz, Roxanne K., Rumfelt, Shannon, Chen, Ning, Zhang, Dawei, Tasker, Andrew S., Bürli, Roland, Hungate, Randall, Yu, Violeta, Nguyen, Yen, Whittington, Douglas A., Meagher, Kristin L., Plant, Matthew, Tudor, Yanyan, Schrag, Michael, Xu, Yang, Ng, Gordon Y., Hu, Essa
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
HU ESSA, KUNZ ROXANNE, RUMFELT SHANNON, CHEN NING, BOURBEAU MATTHEW P, ALLEN JENNIFER R
Year of Publication 20.07.2011
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Year of Publication 20.07.2011
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PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
NISHIMURA NOBUKO, LOW JONATHAN D, AMEGADZIE ALBERT, HARRINGTON PAUL E, MA VU VAN, WHITE RYAN, ALLEN JENNIFER R, SMITH ADRIAN L, SHAM KELVIN, XUE QIUFEN, QIAN WENYUAN, RUMFELT SHANNON, FROHN MICHAEL J, GUZMAN PEREZ ANGEL, BROWN JAMES, RZASA ROBERT M, MINATTI ANA ELENA, LOPEZ PATRICIA
Year of Publication 06.11.2015
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Year of Publication 06.11.2015
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NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS
HARRINGTON ESSA HU, CHEN JIAN J, LIU QINGYIAN, RUMFELT SHANNON, FROHN MICHAEL J, ZHONG WENGE, RZASA ROBERT M, PICKRELL ALEXANDER J, ALLEN JENNIFER R
Year of Publication 19.06.2013
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Year of Publication 19.06.2013
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PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
HU ESSA, PICKRELL ALEX, DEMORIN FRENEL FILS, FALSEY JAMES R, FROHN MIKE, REICHELT ANDREAS, RZASA ROB, ALLEN JENNIFER R, NGUYEN TOM, YAO GUOMIN, HARRINGTON PAUL, CHAVEZ FRANK JR, SHAM KELVIN, BISWAS KAUSTAV, KUNZ ROXANNE, RUMFELT SHANNON, CHEN NING, MONENSCHEIN HOLGER, HORNE DANIEL B, KALLER MATTHEW R
Year of Publication 28.07.2011
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Year of Publication 28.07.2011
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derivados de piridina e pirimidina como inibidores de fosfodiesterase 10
Ning Chen, Essa Hu, Jennifer R. Allen, Shannon Rumfelt, Roxanne Kunz, Matthew P. Bourbeau
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
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CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
MINATTI, ANA ELENA, ALLEN, JENNIFER R, QIAN, WENYUAN, CHENG, YUAN, GUZMAN-PEREZ, ANGEL, CHEN, JIAN J, WHITE, RYAN D, LIU, LONGBIN, AMEGADZIE, ALBERT, MANNING, JAMES R, PICKRELL, ALEXANDER J, RUMFELT, SHANNON, NISHIMURA, NOBUKO, LIU, QINGYIAN, STEC, MARKIAN M, LOW, JONATHAN D, RZASA, ROBERT M, NGUYEN, THOMAS T, NORMAN, MARK H, BROWN, JAMES A, MA, VU VAN, PETTUS, LIPING H, BOURBEAU, MATTHEW P, HARRINGTON, PAUL E, SIEGMUND, AARON C, FROHN, MICHAEL J, XUE, QIUFEN
Year of Publication 24.01.2023
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Year of Publication 24.01.2023
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PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
MINATTI, ANA ELENA, ZHONG, WENGE, RUMFELT, SHANNON, CHEN, NING, LOPEZ, PATRICIA, LIU, QINGYIAN, ALLEN, JENNIFER R, LOW, JONATHAN D, CHEN, JIAN, TAMAYO, NURIA A, QIAN, WENYUAN, RZASA, ROBERT M, CHENG, YUAN, YANG, BRYANT, JUDD, TED, XUE, QIUFEN
Year of Publication 13.10.2020
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Year of Publication 13.10.2020
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PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
MINATTI, ANA ELENA, WHITE, RYAN, RUMFELT, SHANNON, SMITH, ADRIAN L, SHAM, KELVIN, LOPEZ, PATRICIA, NISHIMURA, NOBUKO, ALLEN, JENNIFER R, LOW, JONATHAN D, QIAN, WENYUAN, RZASA, ROBERT M, MA, VU, GUZMAN-PEREZ, ANGEL, BROWN, JAMES, HARRINGTON, PAUL E, FROHN, MICHAEL J, XUE, QIUFEN, AMEGADZIE, ALBERT
Year of Publication 20.07.2021
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Year of Publication 20.07.2021
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PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
JUDD, Ted, MINATTI, Ana Elena, LOPEZ, Patricia, XUE, Qiufen, QIAN, Wenyuan, ZHONG, Wenge, ALLEN, Jennifer R, RZASA, Robert M, YANG, Bryant, CHENG, Yuan, RUMFELT, Shannon, CHEN, Jian, CHEN, Ning, LOW, Jonathan D, LIU, Qingyian, TAMAYO, Nuria A
Year of Publication 09.10.2019
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Year of Publication 09.10.2019
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NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS
HARRINGTON ,ESSAU HU, PICKRELL AKEXANDER J, CHEN JIAN J, RUMFELT SHANNON, LIU QINGYIAN, ZHONG WENGE, FROHN MICHAEL J, RZASA ROBERT M, ALLEN JENNIFER R
Year of Publication 29.11.2017
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Year of Publication 29.11.2017
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Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
Cheng, Yuan, Minatti, Ana Elena, Chen, Ning, Low, Jonathan D, Rumfelt, Shannon, Rzasa, Robert M, Yang, Bryant, Lopez, Patricia, Xue, Qiufen, Judd, Ted, Chen, Jian, Liu, Qingyian, Allen, Jenifer R, Qian, Wenyuan, Zhong, Wenge, Tamayo, Nuria A
Year of Publication 18.10.2018
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Year of Publication 18.10.2018
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