The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs
Abramovitz, Mark, Adam, Mohammed, Boie, Yves, Carrière, Marie-Claude, Denis, Danielle, Godbout, Claude, Lamontagne, Sonia, Rochette, Chantal, Sawyer, Nicole, Tremblay, Nathalie M, Belley, Michel, Gallant, Michel, Dufresne, Claude, Gareau, Yves, Ruel, Rejean, Juteau, Helene, Labelle, Marc, Ouimet, Nathalie, Metters, Kathleen M
Published in Biochimica et biophysica acta (17.01.2000)
Published in Biochimica et biophysica acta (17.01.2000)
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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Fares, Iman, Chagraoui, Jalila, Gareau, Yves, Gingras, Stéphane, Ruel, Réjean, Mayotte, Nadine, Csaszar, Elizabeth, Knapp, David J. H. F., Miller, Paul, Ngom, Mor, Imren, Suzan, Roy, Denis-Claude, Watts, Kori L., Kiem, Hans-Peter, Herrington, Robert, Iscove, Norman N., Humphries, R. Keith, Eaves, Connie J., Cohen, Sandra, Marinier, Anne, Zandstra, Peter W., Sauvageau, Guy
Published in Science (American Association for the Advancement of Science) (19.09.2014)
Published in Science (American Association for the Advancement of Science) (19.09.2014)
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Identification of small molecules that support human leukemia stem cell activity ex vivo
Pabst, Caroline, Krosl, Jana, Fares, Iman, Boucher, Geneviève, Ruel, Réjean, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy
Published in Nature methods (01.04.2014)
Published in Nature methods (01.04.2014)
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Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen
Pelletier, Benoit, Duhamel, Stéphanie, Tambutet, Guillaume, Jarvis, Scott, Cléroux, Patrick, David, Maud, Tanguay, Pierre-Luc, Voisin, Laure, James, Clint, Lavoie, Rico, Gareau, Yves, Flynn-Robitaille, Joël, Lorca, Thierry, Ruel, Réjean, Marinier, Anne, Meloche, Sylvain
Published in ACS chemical biology (19.05.2023)
Published in ACS chemical biology (19.05.2023)
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Chemogenomic Landscape of RUNX1 -mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
Simon, Laura, Lavallée, Vincent-Philippe, Bordeleau, Marie-Eve, Krosl, Jana, Baccelli, Irène, Boucher, Geneviève, Lehnertz, Bernhard, Chagraoui, Jalila, MacRae, Tara, Ruel, Réjean, Chantigny, Yves, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy
Published in Clinical cancer research (15.11.2017)
Published in Clinical cancer research (15.11.2017)
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Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
Qiao, Jennifer X, Wang, Tammy C, Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A, Spronk, Steven A, Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M, Abell, Lynn M, Hua, Ji, Price, Laura A, Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E, Bostwick, Jeffrey S, Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia
Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Spinella, Jean-François, Fortier, Simon, Boivin, Isabel, Mendoza-Sanchez, Rodrigo, Thavonekham, Bounkham, MacRae, Tara, Mayotte, Nadine, Bonneil, Eric, Wittman, Mark, Carmichael, James, Ruel, Réjean, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy
Published in Science advances (22.03.2024)
Published in Science advances (22.03.2024)
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New azole antagonists with high affinity for the P2Y(1) receptor
Ruel, Rejean, L'Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Journal Article
Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML
Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Fortier, Simon, Boivin, Isabel, Spinella, Jean-Francois, Macrae, Tara, Ruel, Rejean, Hebert, Josee, Marinier, Anne, Sauvageau, Guy
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Identification of a Novel Cyclin K Degrader Molecule with Selective Anti-AML Activity
Gracias, Deanne, Moison, Céline, Mendoza-Sanchez, Rodrigo, Fortier, Simon, Girard, Simon, Spinella, Jean-Francois, Macrae, Tara, Thavonekham, Bounkham, Ruel, Rejean, Hebert, Josee, Marinier, Anne, Sauvageau, Guy
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
Krosl, Jana, Bordeleau, Marie-Eve, Moison, Céline, MacRae, Tara, Boivin, Isabel, Mayotte, Nadine, Gracias, Deanne, Baccelli, Irène, Lavallée, Vincent-Philippe, Bisaillon, Richard, Lehnertz, Bernhard, Mendoza-Sanchez, Rodrigo, Ruel, Réjean, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Boucher, Geneviève, Noronha, Nandita, Pabst, Caroline, Tyers, Mike, Gendron, Patrick, Lemieux, Sébastien, Barabé, Frédéric, Marinier, Anne, Hébert, Josée, Sauvageau, Guy
Published in Blood advances (25.01.2022)
Published in Blood advances (25.01.2022)
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New azole antagonists with high affinity for the P2Y1 receptor
Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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1023 – THE IMPORTANCE OF STEM CELL EXPANSION IN TOMORROW'S MEDICINE
Sauvageau, Guy, Chagraoui, Jalila, Tomellini, Elisa, Rojas-Sutterlin, Shanti, Corneau, Sophie, Girard, Simon, Tellelchea, Maria Florencia, Gingras, Stephane, Gareau, Yves, Ruel, Rejean, Cohen, Sandra, Milano, Filippo, Marinier, Anne
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
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Journal Article
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds
Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Lapointe, Philippe, Martel, Alain, Qiao, Jennifer X., Hua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1 '-Neopentylspiro[indoline-3,4 '-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y(1) Antagonist
Qiao, Jennifer X., Wang, Tammy C., Ruel, Rejean, Thibeault, Carl, L'Heureux, Alexandre, Schumacher, William A., Spronk, Steven A., Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M., Abell, Lynn M., Hua, Ji, Price, Laura A., Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E., Bostwick, Jeffrey S., Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A., Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Journal of medicinal chemistry (28.11.2013)
Published in Journal of medicinal chemistry (28.11.2013)
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Journal Article
Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine
Thibault, Carl, L'Heureux, Alexandre, Bhide, Rajeev S, Ruel, Réjean
Published in Organic letters (25.12.2003)
Published in Organic letters (25.12.2003)
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Journal Article
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)- N-(2-methyl-1 H-pyrrolo[2,3- b]pyridin-5-yl)pyrrolo[2,1- f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor
Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Martel, Alain, Cai, Zhen-Wei, Wei, Donna, Qian, Ligang, Barrish, Joel C., Mathur, Arvind, D’Arienzo, Celia, Hunt, John T., Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Derbin, George, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Henley, Benjamin, Tejwani, Ravindra, Bhide, Rajeev S., Trainor, George L., Fargnoli, Joseph, Lombardo, Louis J.
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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