Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Get full text
Journal Article
Discovery and SAR studies of novel GlyT1 inhibitors
Walter, Magnus W., Hoffman, Beth J., Gordon, Kimberly, Johnson, Kirk, Love, Patrick, Jones, Matthew, Man, Teresa, Phebus, Lee, Reel, Jon K., Rudyk, Helene C., Shannon, Harlan, Svensson, Kjell, Yu, Hong, Valli, Matthew J., Porter, Warren J.
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Get full text
Journal Article
Exploiting domino enyne metathesis mechanisms for skeletal diversity generation
Spandl, Richard J., Rudyk, Helene, Spring, David R.
Published in Chemical communications (Cambridge, England) (01.01.2008)
Published in Chemical communications (Cambridge, England) (01.01.2008)
Get full text
Journal Article
Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis
Thomas, Gemma L., Spandl, Richard J., Glansdorp, Freija G., Welch, Martin, Bender, Andreas, Cockfield, Joshua, Lindsay, Jodi A., Bryant, Clare, Brown, Derek F. J., Loiseleur, Olivier, Rudyk, Hélène, Ladlow, Mark, Spring, David R.
Published in Angewandte Chemie (International ed.) (31.03.2008)
Published in Angewandte Chemie (International ed.) (31.03.2008)
Get full text
Journal Article
In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion
Kirby, Louise, Birkett, Christopher R, Rudyk, Helene, Gilbert, Ian H, Hope, James
Published in Journal of general virology (01.04.2003)
Published in Journal of general virology (01.04.2003)
Get full text
Journal Article
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu(2) Receptor Agonist
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R., Hen, Steven S., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Getman, Brian G., Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (18.03.2016)
Published in Journal of medicinal chemistry (18.03.2016)
Get full text
Journal Article
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M. A., Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
Get full text
Journal Article
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt)
Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
Get full text
Journal Article
Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
Get full text
Journal Article
Synthesis and Pharmacological Characterization of C 4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 R ,2 S ,4 R ,5 R ,6 R )-2-Amino-4-(1 H -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu 2 Receptor Agonist
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R., Henry, Steven S., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Getman, Brian G., Catlow, John T., Swanson, Steven, Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
Get full text
Journal Article
Synthesis of Analogues of Congo Red and Evaluation of Their Anti-Prion Activity
Sellarajah, Shane, Lekishvili, Tamuna, Bowring, Claire, Thompsett, Andrew R, Rudyk, Helene, Birkett, Christopher R, Brown, David R, Gilbert, Ian H
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
Get full text
Journal Article
Synthesis of super(11)C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET
Schou, Magnus, Pike, Victor W, Sovago, Judit, Gulyas, Balazs, Gallagher, Peter T, Dobson, David R, Walter, Magnus W, Rudyk, Helene, Farde, Lars, Halldin, Christer
Published in Bioorganic & medicinal chemistry (01.01.2007)
Published in Bioorganic & medicinal chemistry (01.01.2007)
Get full text
Journal Article
Synthesis of 11C-labelled ( R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET
Schou, Magnus, Pike, Victor W., Sóvágó, Judit, Gulyás, Balázs, Gallagher, Peter T., Dobson, David R., Walter, Magnus W., Rudyk, Helene, Farde, Lars, Halldin, Christer
Published in Bioorganic & medicinal chemistry (2007)
Published in Bioorganic & medicinal chemistry (2007)
Get full text
Journal Article
ON THE WAY TO GLYCOPROCESSING INHIBITORS - A GENERAL ONE-POT SYNTHESIS OF IMIDAZOLOSUGARS
STREITH, J, BOIRON, A, FRANKOWSKI, A, LENOUEN, D, RUDYK, H, TSCHAMBER, T
Published in Synthesis (Stuttgart) (01.08.1995)
Published in Synthesis (Stuttgart) (01.08.1995)
Get more information
Journal Article
COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T
RICHARDSON, Timothy Ivo, MORPHY, John Richard, SAPMAZ, Selma, LUGAR, Charles Willis III, RUDYK, Helene, STITES, Ryan Edward
Year of Publication 14.04.2021
Get full text
Year of Publication 14.04.2021
Patent
Compounds useful for inhibiting RORγt
Richardson, Timothy Ivo, Sapmaz, Selma, Lugar, III, Charles Willis, Morphy, John Richard, Stites, Ryan Edward, Vaught, Grant Mathews, Rudyk, Helene, Clarke, Christian Alexander
Year of Publication 18.05.2021
Get full text
Year of Publication 18.05.2021
Patent
Compounds useful for inhibiting ROR-gamma-t
Richardson, Timothy Ivo, Sapmaz, Selma, Lugar, III, Charles Willis, Rudyk, Helene Catherine Eugenie, Morphy, John Richard, Stites, Ryan Edward
Year of Publication 31.03.2020
Get full text
Year of Publication 31.03.2020
Patent