Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate
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Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
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Published in ACS chemical neuroscience (20.04.2016)
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Palladium-Catalyzed Coupling of Pyrazole Triflates with Arylboronic Acids
Dvorak, Curt A, Rudolph, Dale A, Ma, Sandy, Carruthers, Nicholas I
Published in Journal of organic chemistry (13.05.2005)
Published in Journal of organic chemistry (13.05.2005)
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Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y2 Receptor
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Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor
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Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX 2R) antagonists
McAtee, Laura C, Sutton, Steven W, Rudolph, Dale A, Li, Xiaobing, Aluisio, Leah E, Phuong, Victor K, Dvorak, Curt A, Lovenberg, Timothy W, Carruthers, Nicholas I, Jones, Todd K
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists
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Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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Novel non-peptidic neuropeptide Y Y2 receptor antagonists
JABLONOWSKI, Jill A, WENYING CHAI, CARRUTHERS, Nicholas I, XIAOBING LI, RUDOLPH, Dale A, MURRAY, William V, YOUNGMAN, Mark A, DAX, Scott L, NEPOMUCENO, Diane, BONAVENTURE, Pascal, LOVENBERG, Timothy W
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyra- zolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate
Dvorak, Curt A., Rudolph, Dale A., Nepomuceno, Diane, Dvorak, Lisa, Lord, Brian, Fraser, Ian, Bonaventure, Pascal, Lovenberg, Timothy, Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT 7/2 inhibitors leading to the identification of a clinical candidate
Dvorak, Curt A, Rudolph, Dale A, Nepomuceno, Diane, Dvorak, Lisa, Lord, Brian, Fraser, Ian, Bonaventure, Pascal, Lovenberg, Timothy, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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치환된 1H-이미다조[4,5-b]피리딘-2(3H)-온 및 GLUN2B 수용체 조절제로서의 이의 용도
LETAVIC MICHAEL A, STENNE BRICE M, CHROVIAN CHRISTA C, JOHNSON AKINOLA SOYODE, RUDOLPH DALE A, RECH JASON C, WALL JESSICA L
Year of Publication 24.05.2019
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Year of Publication 24.05.2019
Patent
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor
Swanson, Devin M, Wong, Victoria D, Jablonowski, Jill A, Shah, Chandra, Rudolph, Dale A, Dvorak, Curt A, Seierstad, Mark, Dvorak, Lisa K, Morton, Kirsten, Nepomuceno, Diane, Atack, John R, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 11.12.2017
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Year of Publication 11.12.2017
Patent
34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 08.12.2017
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Year of Publication 08.12.2017
Patent
Corrigendum to “2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists” [Bioorg. Med. Chem. Lett. 18 (2008) 2103–2108]
Shireman, Brock T., Dvorak, Curt A., Rudolph, Dale A., Bonaventure, Pascal, Nepomuceno, Diane, Dvorak, Lisa, Miller, Kirsten L., Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.07.2008)
Published in Bioorganic & medicinal chemistry letters (15.07.2008)
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Novel human histamine H3 receptor antagonists
SHAH, Chandra, MCATEE, Laura, BREITENBUCHER, J. Guy, RUDOLPH, Dale, XIAOBING LI, LOVENBERG, Timothy W, MAZUR, Curt, WILSON, Sandy J, CARRUTHERS, Nicholas I
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Journal Article
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT 2A antagonists
Shireman, Brock T., Dvorak, Curt A., Rudolph, Dale A., Bonaventure, Pascal, Nepomuceno, Diane, Dvorak, Lisa, Miller, Kirsten L., Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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