Search Results - "RUCHELMAN ALEXANDER" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

by Matyskiela, Mary E, Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn'Al, Lander, Gabriel C, Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L, Handa, Hiroshi, Carmichael, James, Daniel, Thomas O, Cathers, Brian E, Lopez-Girona, Antonia, Chamberlain, Philip P
Published in Nature (London) (14.07.2016)

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Journal Article

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

Special issue of Medicinal Chemistry Research in honor of Professor Edmond J. LaVoie

by Ruchelman, Alexander L., Hu, Longqin
Published in Medicinal chemistry research (01.10.2022)

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Journal Article

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

by Ruchelman, Alexander L., Man, Hon-Wah, Zhang, Weihong, Chen, Roger, Capone, Lori, Kang, Jian, Parton, Anastasia, Corral, Laura, Schafer, Peter H., Babusis, Darius, Moghaddam, Mehran F., Tang, Yang, Shirley, Michael A., Muller, George W.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)

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Journal Article

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

by Ruchelman, Alexander L., Man, Hon-Wah, Chen, Roger, Liu, Wei, Lu, Ling, Cedzik, Dorota, Zhang, Ling, Leisten, Jim, Collette, Alice, Narla, Rama Krishna, Raymon, Heather K., Muller, George W.
Published in Bioorganic & medicinal chemistry (01.11.2011)

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5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-Alkyl Substituents Modulates Sensitivity to Efflux Transporters Associated with Multidrug Resistance

by Ruchelman, Alexander L, Houghton, Peter J, Zhou, Nai, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Journal of medicinal chemistry (10.02.2005)

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Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[ i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

by Zhu, Shejin, Ruchelman, Alexander L., Zhou, Nai, Liu, Angela A., Liu, Leroy F., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry (15.12.2005)

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Journal Article

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug

by LI, Tsai-Kun, HOUGHTON, Peter J, DESAI, Shyamal D, DAROUI, Parima, LIU, Angela A, HARS, Eszter S, RUCHELMAN, Alexander L, LAVOIE, Edmond J, LIU, Leroy F
Published in Cancer research (Chicago, Ill.) (01.12.2003)

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Journal Article

5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

by RUCHELMAN, Alexander L, SINGH, Sudhir K, RAY, Abhijit, XIAO HUA WU, YANG, Jin-Ming, LI, Tsai-Kun, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (01.05.2003)

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Journal Article

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5 -ones : Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5 -ones : Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

by SHEJIN ZHU, RUCHELMAN, Alexander L, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (01.05.2006)

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Journal Article

11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

by RUCHELMAN, Alexander L, SINGH, Sudhir K, RAY, Abhijit, XIAOHUA WU, YANG, Jin-Ming, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry (15.02.2004)

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Journal Article

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

by Singh, Sudhir K, Ruchelman, Alexander L, Li, Tsai-Kun, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Journal of medicinal chemistry (22.05.2003)

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Journal Article

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

by Ruchelman, Alexander L., Singh, Sudhir K., Wu, Xiaohua, Ray, Abhijit, Yang, Jin-Ming, Li, Tsai-Kun, Liu, Angela, Liu, Leroy F., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (18.11.2002)

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Journal Article

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

by Ruchelman, Alexander L, Kerrigan, John E, Li, Tsai-Kun, Zhou, Nai, Liu, Angela, Liu, Leroy F, LaVoie, Edmond J
Published in Bioorganic & medicinal chemistry (01.07.2004)

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Journal Article

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c, h][2,6]naphthyridin-5-ones with potent topoisomerase i-targeting activity and cytotoxicity

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c, h][2,6]naphthyridin-5-ones with potent topoisomerase i-targeting activity and cytotoxicity

by RUCHELMAN, Alexander L, SHEJIN ZHU, NAI ZHOU, LIU, Angela, LIU, Leroy F, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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Journal Article

Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation

Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation

by Ruchelman, Alexander L., Connolly, Terrence J.
Published in Tetrahedron: asymmetry (31.05.2015)

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Journal Article

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

by Matyskiela, Mary E., Lu, Gang, Ito, Takumi, Pagarigan, Barbra, Lu, Chin-Chun, Miller, Karen, Fang, Wei, Wang, Nai-Yu, Nguyen, Derek, Houston, Jack, Carmel, Gilles, Tran, Tam, Riley, Mariko, Nosaka, Lyn’Al, Lander, Gabriel C., Gaidarova, Svetlana, Xu, Shuichan, Ruchelman, Alexander L., Handa, Hiroshi, Carmichael, James, Daniel, Thomas O., Cathers, Brian E., Lopez-Girona, Antonia, Chamberlain, Philip P.
Published in Nature (London) (22.06.2016)

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5H-8,9-Dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c, h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

5H-8,9-Dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c, h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

by KERRIGAN, John E, PILCH, Daniel S, RUCHELMAN, Alexander L, NAI ZHOU, LIU, Angela, LIU, Leroy, LAVOIE, Edmond J
Published in Bioorganic & medicinal chemistry letters (20.10.2003)

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Journal Article

Protein Degradation via CRL4(CRBN) Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

Protein Degradation via CRL4(CRBN) Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1

by Hansen, Joshua D., Condroski, Kevin, Correa, Matthew, Muller, George, Man, Hon-Wah, Ruchelman, Alexander, Zhang, Weihong, Vocanson, Fan, Crea, Tim, Liu, Wei, Lu, Gang, Baculi, Frans, LeBrun, Laurie, Mahmoudi, Afshin, Carmel, Gilles, Hickman, Matt, Lu, Chin-Chun
Published in Journal of medicinal chemistry (25.01.2018)

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Pd-Catalyzed Chemoselective O‑Benzylation of Ambident 2‑Quinolinone Nucleophiles

Pd-Catalyzed Chemoselective O‑Benzylation of Ambident 2‑Quinolinone Nucleophiles

by Cadena, Melissa, Villatoro, Roberto Silva, Gupta, Jyoti Shah, Phillips, Cody, Allen, Jonathan B., Arman, Hadi D., Wherritt, Daniel J., Clanton, Nicholas A., Ruchelman, Alexander L., Simmons, Eric M., DelMonte, Albert J., Coombs, John R., Frantz, Doug E.
Published in ACS catalysis (19.08.2022)

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Journal Article

MK2 억제제, 이의 합성, 및 이의 중간체

MK2 억제제, 이의 합성, 및 이의 중간체

by GEORGE DAVID T, RUCHELMAN ALEXANDER L, COOMBS JOHN R, JOE CANDICE LEE, ZHENG BIN, LIN DONG, ZHU KEMING, LIM DANIEL
Year of Publication 11.10.2023

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