High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
Christensen, Karen E, Mikael, Leonie G, Leung, Kit-Yi, Lévesque, Nancy, Deng, Liyuan, Wu, Qing, Malysheva, Olga V, Best, Ana, Caudill, Marie A, Greene, Nicholas DE, Rozen, Rima
Published in The American journal of clinical nutrition (01.03.2015)
Published in The American journal of clinical nutrition (01.03.2015)
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Journal Article
Epigenome-Wide Association of Liver Methylation Patterns and Complex Metabolic Traits in Mice
Orozco, Luz D., Morselli, Marco, Rubbi, Liudmilla, Guo, Weilong, Go, James, Shi, Huwenbo, Lopez, David, Furlotte, Nicholas A., Bennett, Brian J., Farber, Charles R., Ghazalpour, Anatole, Zhang, Michael Q., Bahous, Renata, Rozen, Rima, Lusis, Aldons J., Pellegrini, Matteo
Published in Cell metabolism (02.06.2015)
Published in Cell metabolism (02.06.2015)
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Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism
Cosín-Tomás, Marta, Luan, Yan, Leclerc, Daniel, Malysheva, Olga V, Lauzon, Nidia, Bahous, Renata H, Christensen, Karen E, Caudill, Marie A, Rozen, Rima
Published in Nutrients (08.06.2020)
Published in Nutrients (08.06.2020)
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Journal Article
Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice
Christensen, Karen E, Malysheva, Olga V, Carlin, Stephanie, Matias, Fernando, MacFarlane, Amanda J, Jacobs, René L, Caudill, Marie A, Rozen, Rima
Published in Nutrients (28.12.2021)
Published in Nutrients (28.12.2021)
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Journal Article
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study
Kahn, Susan R., MD, MSc, Platt, Robert, PhD, McNamara, Helen, MD, MSc, Rozen, Rima, MD, PhD, Chen, Moy Fong, MD, Genest, Jacques, MD, Goulet, Lise, MD, PhD, Lydon, John, PhD, Seguin, Louise, MD, MPH, Dassa, Clement, PhD, Masse, André, MD, Asselin, Guylaine, MD, Benjamin, Alice, MD, Miner, Louise, MD, Ghanem, Antoinette, RN, MSc, Kramer, Michael S., MD
Published in American journal of obstetrics and gynecology (01.02.2009)
Published in American journal of obstetrics and gynecology (01.02.2009)
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Journal Article
High intake of folic acid disrupts embryonic development in mice
Pickell, Laura, Brown, Katharine, Li, Deqiang, Wang, Xiao-Ling, Deng, Liyuan, Wu, Qing, Selhub, Jacob, Luo, Li, Jerome-Majewska, Loydie, Rozen, Rima
Published in Birth defects research. A Clinical and molecular teratology (01.01.2011)
Published in Birth defects research. A Clinical and molecular teratology (01.01.2011)
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Journal Article
Strain-Specific Defects in Testicular Development and Sperm Epigenetic Patterns in 5,10-Methylenetetrahydrofolate Reductase-Deficient Mice
Chan, Donovan, Cushnie, Duncan W, Neaga, Oana R, Lawrance, Andrea K, Rozen, Rima, Trasler, Jacquetta M
Published in Endocrinology (Philadelphia) (01.07.2010)
Published in Endocrinology (Philadelphia) (01.07.2010)
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Journal Article
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase
Elmore, C. Lee, Wu, Xuchu, Leclerc, Daniel, Watson, Erica D., Bottiglieri, Teodoro, Krupenko, Natalia I., Krupenko, Sergey A., Cross, James C., Rozen, Rima, Gravel, Roy A., Matthews, Rowena G.
Published in Molecular genetics and metabolism (01.05.2007)
Published in Molecular genetics and metabolism (01.05.2007)
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Journal Article
Infertility in 5,10-Methylenetetrahydrofolate Reductase (MTHFR)-Deficient Male Mice Is Partially Alleviated by Lifetime Dietary Betaine Supplementation
KELLY, Tamara L. J, NEAGA, Oana R, SCHWAHN, Bernd C, ROZEN, Rima, TRASLER, Jacquetta M
Published in Biology of reproduction (01.03.2005)
Published in Biology of reproduction (01.03.2005)
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Journal Article
Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase
Celtikci, Basak, Lawrance, Andrea K, Wu, Qing, Rozen, Rima
Published in Anti-cancer drugs (01.10.2009)
Published in Anti-cancer drugs (01.10.2009)
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Journal Article
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency
Roy, Marc, Leclerc, Daniel, Wu, Qing, Gupta, Sapna, Kruger, Warren D., Rozen, Rima
Published in Journal of cellular biochemistry (01.10.2008)
Published in Journal of cellular biochemistry (01.10.2008)
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Journal Article
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: Risk of placental abruption
Ananth, Cande V., Elsasser, Denise A., Kinzler, Wendy L., Peltier, Morgan R., Getahun, Darios, Leclerc, Daniel, Rozen, Rima R.
Published in Molecular genetics and metabolism (01.05.2007)
Published in Molecular genetics and metabolism (01.05.2007)
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Journal Article
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption
Ananth, Cande V., PhD, MPH, Peltier, Morgan R., PhD, De Marco, Celeste, RN, BSN, Elsasser, Denise A., MPH, Getahun, Darios, MD, MPH, Rozen, Rima, PhD, Smulian, John C., MD, MPH
Published in American journal of obstetrics and gynecology (01.10.2007)
Published in American journal of obstetrics and gynecology (01.10.2007)
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Journal Article
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
JACQUES, P. F, BOSTOM, A. G, WILLIAMS, R. R, ELLISON, R. C, ECKFELDT, J. H, ROSENBERG, I. H, SELHUB, J, ROZEN, R
Published in Circulation (New York, N.Y.) (1996)
Published in Circulation (New York, N.Y.) (1996)
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