TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Meller, Stephan, Di Domizio, Jeremy, Voo, Kui S, Friedrich, Heike C, Chamilos, Georgios, Ganguly, Dipyaman, Conrad, Curdin, Gregorio, Josh, Le Roy, Didier, Roger, Thierry, Ladbury, John E, Homey, Bernhard, Watowich, Stanley, Modlin, Robert L, Kontoyiannis, Dimitrios P, Liu, Yong-Jun, Arold, Stefan T, Gilliet, Michel
Published in Nature immunology (13.07.2015)
Published in Nature immunology (13.07.2015)
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Journal Article
High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates
Roger, Thierry, Schneider, Anina, Weier, Manuela, Sweep, Fred C. G. J., Le Roy, Didier, Bernhagen, Jürgen, Calandra, Thierry, Giannoni, Eric
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (23.02.2016)
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Journal Article
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
Demarco, Benjamin, Grayczyk, James P, Bjanes, Elisabet, Le Roy, Didier, Tonnus, Wulf, Assenmacher, Charles-Antoine, Radaelli, Enrico, Fettrelet, Timothée, Mack, Vanessa, Linkermann, Andreas, Roger, Thierry, Brodsky, Igor E, Chen, Kaiwen W, Broz, Petr
Published in Science advances (01.11.2020)
Published in Science advances (01.11.2020)
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Journal Article
Seasonal migration, site fidelity, and population structure of European seabass (Dicentrarchus labrax)
de Pontual, Helene, Heerah, Karine, Goossens, Jolien, Garren, François, Martin, Stephane, Le Ru, Loic, Le Roy, Didier, Woillez, Mathieu
Published in ICES journal of marine science (11.08.2023)
Published in ICES journal of marine science (11.08.2023)
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Journal Article
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome
Delaloye, Julie, Roger, Thierry, Steiner-Tardivel, Quynh-Giao, Le Roy, Didier, Knaup Reymond, Marlies, Akira, Shizuo, Petrilli, Virginie, Gomez, Carmen E, Perdiguero, Beatriz, Tschopp, Jürg, Pantaleo, Giuseppe, Esteban, Mariano, Calandra, Thierry
Published in PLoS pathogens (01.06.2009)
Published in PLoS pathogens (01.06.2009)
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Journal Article
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection
Ciarlo, Eleonora, Heinonen, Tytti, Théroude, Charlotte, Herderschee, Jacobus, Mombelli, Matteo, Lugrin, Jérôme, Pfefferlé, Marc, Tyrrell, Beatrice, Lensch, Sarah, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry
Published in Frontiers in immunology (28.08.2017)
Published in Frontiers in immunology (28.08.2017)
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Journal Article
Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’
Katzmarski, Natalie, Domínguez-Andrés, Jorge, Cirovic, Branko, Renieris, Georgios, Ciarlo, Eleonora, Le Roy, Didier, Lepikhov, Konstantin, Kattler, Kathrin, Gasparoni, Gilles, Händler, Kristian, Theis, Heidi, Beyer, Marc, van der Meer, Jos W. M., Joosten, Leo A. B., Walter, Jörn, Schultze, Joachim L., Roger, Thierry, Giamarellos-Bourboulis, Evangelos J., Schlitzer, Andreas, Netea, Mihai G.
Published in Nature immunology (01.02.2022)
Published in Nature immunology (01.02.2022)
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Journal Article
Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF
Kerschbaumer, Randolf J., Rieger, Manfred, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Garbaraviciene, Jurate, Boehncke, Wolf-Henning, Müllberg, Jürgen, Hoet, Rene M., Wood, Clive R., Antoine, Gerhard, Thiele, Michael, Savidis-Dacho, Helga, Dockal, Michael, Ehrlich, Hartmut, Calandra, Thierry, Scheiflinger, Friedrich
Published in The Journal of biological chemistry (02.03.2012)
Published in The Journal of biological chemistry (02.03.2012)
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Journal Article
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra, Thierry, Echtenacher, Bernd, Roy, Didier Le, Pugin, Jérôme, Metz, Christine N, Hültner, Lothar, Heumann, Didier, Männel, Daniela, Bucala, Richard, Glauser, Michel P
Published in Nature medicine (01.02.2000)
Published in Nature medicine (01.02.2000)
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Journal Article
A New Class of Isothiocyanate-Based Irreversible Inhibitors of Macrophage Migration Inhibitory Factor
Ouertatani-Sakouhi, Hajer, El-Turk, Farah, Fauvet, Bruno, Roger, Thierry, Le Roy, Didier, Karpinar, Damla Pinar, Leng, Lin, Bucala, Richard, Zweckstetter, Markus, Calandra, Thierry, Lashuel, Hilal A
Published in Biochemistry (Easton) (20.10.2009)
Published in Biochemistry (Easton) (20.10.2009)
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Journal Article
Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses
Heinonen, Tytti, Ciarlo, Eleonora, Le Roy, Didier, Roger, Thierry
Published in Frontiers in immunology (01.10.2019)
Published in Frontiers in immunology (01.10.2019)
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Journal Article
Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Brochut, Maëlick, Heinonen, Tytti, Snäkä, Tiia, Gilbert, Charly, Le Roy, Didier, Roger, Thierry
Published in Scientific reports (10.09.2024)
Published in Scientific reports (10.09.2024)
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Journal Article
Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection
Roger, Thierry, Lugrin, Jérôme, Le Roy, Didier, Goy, Geneviève, Mombelli, Matteo, Koessler, Thibaud, Ding, Xavier C., Chanson, Anne-Laure, Reymond, Marlies Knaup, Miconnet, Isabelle, Schrenzel, Jacques, François, Patrice, Calandra, Thierry
Published in Blood (27.01.2011)
Published in Blood (27.01.2011)
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Journal Article
Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells
Vacher, Gaëlle, Ciarlo, Eleonora, Savova-Bianchi, Dessislava, Le Roy, Didier, Hantier, Gregoire, Niculita-Hirzel, Hélène, Roger, Thierry
Published in Journal of Toxicology and Environmental Health, Part A (18.07.2015)
Published in Journal of Toxicology and Environmental Health, Part A (18.07.2015)
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Journal Article
The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size
Fuchs, Katharina, Cardona Gloria, Yamel, Wolz, Olaf‐Oliver, Herster, Franziska, Sharma, Lokesh, Dillen, Carly A, Täumer, Christoph, Dickhöfer, Sabine, Bittner, Zsofia, Dang, Truong‐Minh, Singh, Anurag, Haischer, Daniel, Schlöffel, Maria A, Koymans, Kirsten J, Sanmuganantham, Tharmila, Krach, Milena, Roger, Thierry, Le Roy, Didier, Schilling, Nadine A, Frauhammer, Felix, Miller, Lloyd S, Nürnberger, Thorsten, LeibundGut‐Landmann, Salomé, Gust, Andrea A, Macek, Boris, Frank, Martin, Gouttefangeas, Cécile, Dela Cruz, Charles S, Hartl, Dominik, Weber, Alexander NR
Published in EMBO reports (01.12.2018)
Published in EMBO reports (01.12.2018)
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Journal Article
COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry
Published in European journal of immunology (01.10.2022)
Published in European journal of immunology (01.10.2022)
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Journal Article
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia
Heinonen, Tytti, Ciarlo, Eleonora, Rigoni, Ersilia, Regina, Jean, Le Roy, Didier, Roger, Thierry
Published in Frontiers in immunology (26.11.2019)
Published in Frontiers in immunology (26.11.2019)
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