Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne, Collins, Ian, Davies, Faith E, Pearl, Laurence H
Published in The EMBO journal (02.03.2011)
Published in The EMBO journal (02.03.2011)
Get full text
Journal Article
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa, Workman, Paul
Published in Cancer research (Chicago, Ill.) (15.04.2008)
Published in Cancer research (Chicago, Ill.) (15.04.2008)
Get full text
Journal Article
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
Get full text
Journal Article
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
Jones, Alan M., Westwood, Isaac M., Osborne, James D., Matthews, Thomas P., Cheeseman, Matthew D., Rowlands, Martin G., Jeganathan, Fiona, Burke, Rosemary, Lee, Diane, Kadi, Nadia, Liu, Manjuan, Richards, Meirion, McAndrew, Craig, Yahya, Norhakim, Dobson, Sarah E., Jones, Keith, Workman, Paul, Collins, Ian, van Montfort, Rob L. M.
Published in Scientific reports (06.10.2016)
Published in Scientific reports (06.10.2016)
Get full text
Journal Article
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70
Cheeseman, Matthew D, Westwood, Isaac M, Barbeau, Olivier, Rowlands, Martin, Dobson, Sarah, Jones, Alan M, Jeganathan, Fiona, Burke, Rosemary, Kadi, Nadia, Workman, Paul, Collins, Ian, van Montfort, Rob L. M, Jones, Keith
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
Get full text
Journal Article
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
Stimson, Lindsay, Rowlands, Martin G, Newbatt, Yvette M, Smith, Nicola F, Raynaud, Florence I, Rogers, Paul, Bavetsias, Vassilios, Gorsuch, Stephen, Jarman, Michael, Bannister, Andrew, Kouzarides, Tony, McDonald, Edward, Workman, Paul, Aherne, G Wynne
Published in Molecular cancer therapeutics (01.10.2005)
Published in Molecular cancer therapeutics (01.10.2005)
Get full text
Journal Article
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration
Caldwell, John J, Davies, Thomas G, Donald, Alastair, McHardy, Tatiana, Rowlands, Martin G, Aherne, G. Wynne, Hunter, Lisa K, Taylor, Kevin, Ruddle, Ruth, Raynaud, Florence I, Verdonk, Marcel, Workman, Paul, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (10.04.2008)
Published in Journal of medicinal chemistry (10.04.2008)
Get full text
Journal Article
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
Cheung, Kwai-Ming J., Matthews, Thomas P., James, Karen, Rowlands, Martin G., Boxall, Katherine J., Sharp, Swee Y., Maloney, Alison, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Aherne, G. Wynne, McDonald, Edward, Workman, Paul
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Published in Bioorganic & medicinal chemistry letters (15.07.2005)
Get full text
Journal Article
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)
Gorsuch, Stephen, Bavetsias, Vassilios, Rowlands, Martin G., Aherne, G. Wynne, Workman, Paul, Jarman, Michael, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.01.2009)
Published in Bioorganic & medicinal chemistry (15.01.2009)
Get full text
Journal Article
Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design
Donald, Alastair, McHardy, Tatiana, Rowlands, Martin G, Hunter, Lisa-Jane K, Davies, Thomas G, Berdini, Valerio, Boyle, Robert G, Aherne, G. Wynne, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
Get full text
Journal Article
Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies
Day, James E. H., Sharp, Swee Y., Rowlands, Martin G., Aherne, Wynne, Lewis, William, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Workman, Paul, Moody, Christopher J.
Published in Chemistry : a European journal (10.09.2010)
Published in Chemistry : a European journal (10.09.2010)
Get full text
Journal Article
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
SHARP, Swee Y, BOXALL, Kathy, PATTERSON, Lisa, MATTHEWS, Thomas P, CHEUNG, Kwai-Ming J, BALL, Karen, HAYES, Angela, RAYNAUD, Florence, MARAIS, Richard, PEARL, Laurence, ECCLES, Sue, AHERNE, Wynne, ROWLANDS, Martin, MCDONALD, Edward, WORKMAN, Paul, PRODROMOU, Chrisostomos, ROE, S. Mark, MALONEY, Alison, POWERS, Marissa, CLARKE, Paul A, BOX, Gary, SANDERSON, Sharon
Published in Cancer research (Chicago, Ill.) (01.03.2007)
Published in Cancer research (Chicago, Ill.) (01.03.2007)
Get full text
Journal Article
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Pierrat, Olivier A., Liu, Manjuan, Collie, Gavin W., Shetty, Kartika, Rodrigues, Matthew J., Le Bihan, Yann-Vaï, Gunnell, Emma A., McAndrew, P. Craig, Stubbs, Mark, Rowlands, Martin G., Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R., Cheung, Kwai-Ming J., Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A., Lloyd, Matthew G., Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I., Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W., Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L. M.
Published in Scientific reports (03.11.2022)
Published in Scientific reports (03.11.2022)
Get full text
Journal Article
Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies
Day, James E. H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Hayes, Angela, Raynaud, Florence I, Lewis, William, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul, Moody, Christopher J
Published in ACS chemical biology (16.12.2011)
Published in ACS chemical biology (16.12.2011)
Get full text
Journal Article
Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit
Rowlands, Martin, McAndrew, Craig, Prodromou, Chris, Pearl, Laurence, Kalusa, Andrew, Jones, Keith, Workman, Paul, Aherne, Wynne
Published in SLAS discovery (01.03.2010)
Published in SLAS discovery (01.03.2010)
Get full text
Journal Article
Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor α
Gallo, Dominique, Jacquemotte, Françoise, Cleeren, Anny, Laïos, Ioanna, Hadiy, Samira, Rowlands, Martin G., Caille, Olivier, Nonclercq, Denis, Laurent, Guy, Jacquot, Yves, Leclercq, Guy
Published in Molecular and cellular endocrinology (30.03.2007)
Published in Molecular and cellular endocrinology (30.03.2007)
Get full text
Journal Article
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Collins, Ian, Caldwell, John, Fonseca, Tatiana, Donald, Alastair, Bavetsias, Vassilios, Hunter, Lisa-Jane K., Garrett, Michelle D., Rowlands, Martin G., Aherne, G. Wynne, Davies, Thomas G., Berdini, Valerio, Woodhead, Steven J., Davis, Deborah, Seavers, Lisa C.A., Wyatt, Paul G., Workman, Paul, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.02.2006)
Published in Bioorganic & medicinal chemistry (15.02.2006)
Get full text
Journal Article