Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
Hancock, Laura A., Hennessy, Corinne E., Solomon, George M., Dobrinskikh, Evgenia, Estrella, Alani, Hara, Naoko, Hill, David B., Kissner, William J., Markovetz, Matthew R., Grove Villalon, Diane E., Voss, Matthew E., Tearney, Guillermo J., Carroll, Kate S., Shi, Yunlong, Schwarz, Marvin I., Thelin, William R., Rowe, Steven M., Yang, Ivana V., Evans, Christopher M., Schwartz, David A.
Published in Nature communications (18.12.2018)
Published in Nature communications (18.12.2018)
Get full text
Journal Article
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist
Nichols, David P, Morgan, Sarah J, Skalland, Michelle, Vo, Anh T, Van Dalfsen, Jill M, Singh, Sachinkumar Bp, Ni, Wendy, Hoffman, Lucas R, McGeer, Kailee, Heltshe, Sonya L, Clancy, John P, Rowe, Steven M, Jorth, Peter, Singh, Pradeep K
Published in The Journal of clinical investigation (15.05.2023)
Published in The Journal of clinical investigation (15.05.2023)
Get full text
Journal Article
The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis
Shei, Ren-Jay, Peabody, Jacelyn E, Kaza, Niroop, Rowe, Steven M
Published in Current opinion in pharmacology (01.12.2018)
Published in Current opinion in pharmacology (01.12.2018)
Get full text
Journal Article
Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression
Roy, Bijoyita, Friesen, Westley J., Tomizawa, Yuki, Leszyk, John D., Zhuo, Jin, Johnson, Briana, Dakka, Jumana, Trotta, Christopher R., Xue, Xiaojiao, Mutyam, Venkateshwar, Keeling, Kim M., Mobley, James A., Rowe, Steven M., Bedwell, David M., Welch, Ellen M., Jacobson, Allan
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Get full text
Journal Article
Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD
Dransfield, Mark T, Wilhelm, Andrew M, Flanagan, Brian, Courville, Clifford, Tidwell, Sherry L, Raju, S Vamsee, Gaggar, Amit, Steele, Chad, Tang, Li Ping, Liu, Bo, Rowe, Steven M
Published in Chest (01.08.2013)
Published in Chest (01.08.2013)
Get more information
Journal Article
An ex vivo rat trachea model reveals abnormal airway physiology and a gland secretion defect in cystic fibrosis
Harris, Elex, Easter, Molly, Ren, Janna, Krick, Stefanie, Barnes, Jarrod, Rowe, Steven M
Published in PloS one (24.10.2023)
Published in PloS one (24.10.2023)
Get full text
Journal Article
A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease
Sloane, Peter A, Shastry, Suresh, Wilhelm, Andrew, Courville, Clifford, Tang, Li Ping, Backer, Kyle, Levin, Elina, Raju, S Vamsee, Li, Yao, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William, Sorscher, Eric J, Dransfield, Mark T, Rowe, Steven M
Published in PloS one (29.06.2012)
Published in PloS one (29.06.2012)
Get full text
Journal Article
A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial
Boyle, Michael P, Bell, Scott C, Konstan, Michael W, McColley, Susanna A, Rowe, Steven M, Rietschel, Ernst, Huang, Xiaohong, Waltz, David, Patel, Naimish R, Rodman, David
Published in The lancet respiratory medicine (01.07.2014)
Published in The lancet respiratory medicine (01.07.2014)
Get more information
Journal Article
Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography
Liu, Linbo, Chu, Kengyeh K, Houser, Grace H, Diephuis, Bradford J, Li, Yao, Wilsterman, Eric J, Shastry, Suresh, Dierksen, Gregory, Birket, Susan E, Mazur, Marina, Byan-Parker, Suzanne, Grizzle, William E, Sorscher, Eric J, Rowe, Steven M, Tearney, Guillermo J
Published in PloS one (23.01.2013)
Published in PloS one (23.01.2013)
Get full text
Journal Article
Efficacy and safety of ivacaftor in patients with cystic fibrosis who have an Arg117His-CFTR mutation: a double-blind, randomised controlled trial
Moss, Richard B, Flume, Patrick A, Elborn, J Stuart, Cooke, Jon, Rowe, Steven M, McColley, Susanna A, Rubenstein, Ronald C, Higgins, Mark
Published in The lancet respiratory medicine (01.07.2015)
Published in The lancet respiratory medicine (01.07.2015)
Get more information
Journal Article
The therapeutic potential of CFTR modulators for COPD and other airway diseases
Solomon, George M, Fu, Lianwu, Rowe, Steven M, Collawn, James F
Published in Current opinion in pharmacology (01.06.2017)
Published in Current opinion in pharmacology (01.06.2017)
Get full text
Journal Article
Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats
Tuggle, Katherine L, Birket, Susan E, Cui, Xiaoxia, Hong, Jeong, Warren, Joe, Reid, Lara, Chambers, Andre, Ji, Diana, Gamber, Kevin, Chu, Kengyeh K, Tearney, Guillermo, Tang, Li Ping, Fortenberry, James A, Du, Ming, Cadillac, Joan M, Bedwell, David M, Rowe, Steven M, Sorscher, Eric J, Fanucchi, Michelle V
Published in PloS one (07.03.2014)
Published in PloS one (07.03.2014)
Get full text
Journal Article
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR
Birket, Susan E, Davis, Joy M, Fernandez-Petty, Courtney M, Henderson, Alexander G, Oden, Ashley M, Tang, LiPing, Wen, Hui, Hong, Jeong, Fu, Lianwu, Chambers, Andre, Fields, Alvin, Zhao, Gojun, Tearney, Guillermo J, Sorscher, Eric J, Rowe, Steven M
Published in American journal of respiratory and critical care medicine (01.11.2020)
Published in American journal of respiratory and critical care medicine (01.11.2020)
Get full text
Journal Article
Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells
Li, Chao, Liu, Zhong, Anderson, Justin, Liu, Zhongyu, Tang, Liping, Li, Yao, Peng, Ning, Chen, Jianguo, Liu, Xueming, Fu, Lianwu, Townes, Tim M, Rowe, Steven M, Bedwell, David M, Guimbellot, Jennifer, Zhao, Rui
Published in PloS one (29.11.2023)
Published in PloS one (29.11.2023)
Get full text
Journal Article
A Critical Role for LTA₄H in Limiting Chronic Pulmonary Neutrophilic Inflammation
Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin
Published in Science (American Association for the Advancement of Science) (01.10.2010)
Published in Science (American Association for the Advancement of Science) (01.10.2010)
Get full text
Journal Article
Reduced sialylation of airway mucin impairs mucus transport by altering the biophysical properties of mucin
Harris, Elex S., McIntire, Hannah J., Mazur, Marina, Schulz-Hildebrandt, Hinnerk, Leung, Hui Min, Tearney, Guillermo J., Krick, Stefanie, Rowe, Steven M., Barnes, Jarrod W.
Published in Scientific reports (17.07.2024)
Published in Scientific reports (17.07.2024)
Get full text
Journal Article
Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor
Xue, Xiaojiao, Mutyam, Venkateshwar, Tang, Liping, Biswas, Silpak, Du, Ming, Jackson, Laura A, Dai, Yanying, Belakhov, Valery, Shalev, Moran, Chen, Fuquan, Schacht, Jochen, J Bridges, Robert, Baasov, Timor, Hong, Jeong, Bedwell, David M, Rowe, Steven M
Published in American journal of respiratory cell and molecular biology (01.04.2014)
Published in American journal of respiratory cell and molecular biology (01.04.2014)
Get full text
Journal Article