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Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2

by Schaffhauser, Hervé, Rowe, Blake A, Morales, Sylvia, Chavez-Noriega, Laura E, Yin, Ruoyuan, Jachec, Christine, Rao, Sara P, Bain, Gretchen, Pinkerton, Anthony B, Vernier, Jean-Michel, Bristow, Linda J, Varney, Mark A, Daggett, Lorrie P
Published in Molecular pharmacology (01.10.2003)

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Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

by Rowe, Blake A, Schaffhauser, Hervé, Morales, Sylvia, Lubbers, Laura S, Bonnefous, Celine, Kamenecka, Theodore M, McQuiston, Jeffrey, Daggett, Lorrie P
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)

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Unique challenges required reassessment and alterations to critical reagents to rescue a neutralizing antibody assay

Unique challenges required reassessment and alterations to critical reagents to rescue a neutralizing antibody assay

by Rowe, Blake A, Medina-Carle, Katie, Chen, Keguan, Reese, Kimberly J, McCarthy, Kenneth M, Concannon, Amy A, Gunn, George R, Gehman, Andrew P, Jiang, Yong, Meyer, Erik
Published in Bioanalysis (17.07.2024)

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Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

by Melamed, Jeffrey Y., Zartman, Amy E., Kett, Nathan R., Gotter, Anthony L., Uebele, Victor N., Reiss, Duane R., Condra, Cindra L., Fandozzi, Christine, Lubbers, Laura S., Rowe, Blake A., McGaughey, Georgia B., Henault, Martin, Stocco, Rino, Renger, John J., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (01.08.2010)

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Phenyl-tetrazolyl Acetophenones: Discovery of Positive Allosteric Potentiatiors for the Metabotropic Glutamate 2 Receptor

Phenyl-tetrazolyl Acetophenones: Discovery of Positive Allosteric Potentiatiors for the Metabotropic Glutamate 2 Receptor

by Pinkerton, Anthony B, Vernier, Jean-Michel, Schaffhauser, Hervé, Rowe, Blake A, Campbell, Una C, Rodriguez, Dana E, Lorrain, Daniel S, Baccei, Christopher S, Daggett, Lorrie P, Bristow, Linda J
Published in Journal of medicinal chemistry (26.08.2004)

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Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor

by Bonnefous, Céline, Vernier, Jean-Michel, Hutchinson, John H., Gardner, Michael F., Cramer, Merryl, James, Joyce K., Rowe, Blake A., Daggett, Lorrie P., Schaffhauser, Hervé, Kamenecka, Theodore M.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)

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Journal Article

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia

by Govek, Steven P., Bonnefous, Celine, Hutchinson, John H., Kamenecka, Theodore, McQuiston, Jeffrey, Pracitto, Richard, Zhao, Lucy X., Gardner, Michael F., James, Joyce K., Daggett, Lorrie P., Rowe, Blake A., Schaffhauser, Hervé, Bristow, Linda J., Campbell, Una C., Rodriguez, Dana E., Vernier, Jean-Michel
Published in Bioorganic & medicinal chemistry letters (15.09.2005)

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

by Pinkerton, Anthony B., Cube, Rowena V., Hutchinson, John H., James, Joyce K., Gardner, Michael F., Rowe, Blake A., Schaffhauser, Hervé, Rodriguez, Dana E., Campbell, Una C., Daggett, Lorrie P., Vernier, Jean-Michel
Published in Bioorganic & medicinal chemistry letters (15.03.2005)

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MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice

MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice

by Dillon, Gregory M, Lubbers, Laura S, Ferguson, Mitchell T, Lao, Julie Z, Huang, Ruey-Ruey C, Xiao, Jing C, Fong, Tung M, Hale, Jeffrey J, Rupprecht, Kathleen, Miao, Shouwu, Rowe, Blake A, Kornecook, Thomas J, Dodart, Jean-Cosme
Published in Behavioural pharmacology (01.04.2011)

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3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)

3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)

by Cube, Rowena V., Vernier, Jean-Michel, Hutchinson, John H., Gardner, Michael F., James, Joyce K., Rowe, Blake A., Schaffhauser, Herve, Daggett, Lorrie, Pinkerton, Anthony B.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)

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PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ

PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ

by Lubbers, Laura S., Rowe, Blake A., Hodge, Lisa M., Browne, Susan E., Gundersdorf, Richard, Jones, Philip, Hess, Fred J., Reynolds, Ian J.
Published in Journal of pharmacological and toxicological methods (01.05.2010)

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

by PINKERTON, Anthony B, CUBE, Rowena V, HUTCHINSON, John H, ROWE, Blake A, SCHAFFHAUSER, Hervé, XIUMIN ZHAO, DAGGETT, Lorrie P, VERNIER, Jean-Michel
Published in Bioorganic & medicinal chemistry letters (01.11.2004)

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-Thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-Thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators

by Pinkerton, Anthony B., Cube, Rowena V., Hutchinson, John H., James, Joyce K., Gardner, Michael F., Schaffhauser, Hervé, Rowe, Blake A., Daggett, Lorrie P., Vernier, Jean-Michel
Published in Bioorganic & medicinal chemistry letters (06.12.2004)

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Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

by HU, Essa, CHUA, Peter C, TEHRANI, Lida, NAGASAWA, Johnny Y, PINKERTON, Anthony B, ROWE, Blake A, VERNIER, Jean-Michel, HUTCHINSON, John H, COSFORD, Nicholas D. P
Published in Bioorganic & medicinal chemistry letters (18.10.2004)

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Journal Article

Cerebrospinal Fluid Levels of α-Secretase—Cleaved Soluble Amyloid Precursor Protein Mirror Cognition in a Swedish Family With Alzheimer Disease and a Gene Mutation

Cerebrospinal Fluid Levels of α-Secretase—Cleaved Soluble Amyloid Precursor Protein Mirror Cognition in a Swedish Family With Alzheimer Disease and a Gene Mutation

by Almkvist, Ove, Basun, Hans, Wagner, Steven L, Rowe, Blake A, Wahlund, Lars-Olof, Lannfelt, Lars
Published in Archives of neurology (Chicago) (01.05.1997)

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Journal Article Conference Proceeding

Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease

Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease

by Lannfelt, L, Basun, H, Wahlund, L O, Rowe, B A, Wagner, S L
Published in Nature medicine (1995)

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Allosteric Potentiators of the Metabotropic Glutamate Receptor 2 (mGlu2). Part 1. Identification and Synthesis of Phenyl-tetrazolyl Acetophenones

Allosteric Potentiators of the Metabotropic Glutamate Receptor 2 (mGlu2). Part 1. Identification and Synthesis of Phenyl-tetrazolyl Acetophenones

by Pinkerton, Anthony B., Cube, Rowena V., Hutchinson, John H., Rowe, Blake A., Schaffhauser, Herve, Zhao, Xiumin, Daggett, Lorrie P., Vernier, Jean-Michel
Published in ChemInform (22.02.2005)

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Journal Article

Pyrimidine Methyl Anilines: Selective Potentiators for the Metabotropic Glutamate 2 Receptor

Pyrimidine Methyl Anilines: Selective Potentiators for the Metabotropic Glutamate 2 Receptor

by Hu, Essa, Chua, Peter C., Tehrani, Lida, Nagasawa, Johnny Y., Pinkerton, Anthony B., Rowe, Blake A., Vernier, Jean-Michel, Hutchinson, John H., Cosford, Nicholas D. P.
Published in ChemInform (18.01.2005)

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Journal Article