High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain
Herzig, Martin C, Bidinosti, Michael, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Weiss, Andreas, Danner, Simone, Vidotto, Nella, Stauffer, Daniela, Barske, Carmen, Mayer, Franziska, Schmid, Peter, Rovelli, Giorgio, van der Putten, P Herman, Shimshek, Derya R
Published in PloS one (15.05.2012)
Published in PloS one (15.05.2012)
Get full text
Journal Article
Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate
Krumova, Petranka, Reyniers, Lauran, Meyer, Marc, Lobbestael, Evy, Stauffer, Daniela, Gerrits, Bertran, Muller, Lionel, Hoving, Sjouke, Kaupmann, Klemens, Voshol, Johannes, Fabbro, Doriano, Bauer, Andreas, Rovelli, Giorgio, Taymans, Jean-Marc, Bouwmeester, Tewis, Baekelandt, Veerle
Published in The FASEB journal (01.07.2015)
Published in The FASEB journal (01.07.2015)
Get more information
Journal Article
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
HERZIG, Martin C, KOLLY, Carine, SCHNELL, Christian R, MUELLER, Matthias, KINZEL, Bernd, GREVOT, Armelle, BOLOGNANI, Federico, STIRN, Martina, KUHN, Rainer R, KAUPMANN, Klemens, VAN DER PUTTEN, P. Herman, ROVELLI, Giorgio, PERSOHN, Elke, SHIMSHEK, Derya R, THEIL, Diethilde, SCHWEIZER, Tatjana, HAFNER, Thomas, STEMMELEN, Christine, TROXLER, Thomas J, SCHMID, Peter, DANNER, Simone
Published in Human molecular genetics (01.11.2011)
Published in Human molecular genetics (01.11.2011)
Get full text
Journal Article
Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins
Friedmann, Elena, Lemberg, Marius K., Weihofen, Andreas, Dev, Kumlesh K., Dengler, Uwe, Rovelli, Giorgio, Martoglio, Bruno
Published in The Journal of biological chemistry (03.12.2004)
Published in The Journal of biological chemistry (03.12.2004)
Get full text
Journal Article
Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis
Huebscher, Karen J., Lee, Janet, Rovelli, Giorgio, Ludin, Beat, Matus, Andrew, Stauffer, Daniela, Fürst, Peter
Published in Gene (29.11.1999)
Published in Gene (29.11.1999)
Get full text
Journal Article
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
Herzig, Martin C., Kolly, Carine, Persohn, Elke, Theil, Diethilde, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Troxler, Thomas J., Schmid, Peter, Danner, Simone, Schnell, Christian R., Mueller, Matthias, Kinzel, Bernd, Grevot, Armelle, Bolognani, Federico, Stirn, Martina, Kuhn, Rainer R., Kaupmann, Klemens, van der Putten, P. Herman, Rovelli, Giorgio, Shimshek, Derya R.
Published in Human molecular genetics (01.11.2011)
Published in Human molecular genetics (01.11.2011)
Get full text
Journal Article
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production
Martoglio, Bruno, Friedmann, Elena, Hauben, Ehud, Maylandt, Kerstin, Schleeger, Simone, Vreugde, Sarah, Lichtenthaler, Stefan F, Kuhn, Peer-Hendrik, Stauffer, Daniela, Rovelli, Giorgio
Published in Nature cell biology (01.08.2006)
Published in Nature cell biology (01.08.2006)
Get full text
Journal Article
Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway
Carballo-Carbajal, Iria, Weber-Endress, Susanne, Rovelli, Giorgio, Chan, Diane, Wolozin, Benjamin, Klein, Christian L., Patenge, Nadja, Gasser, Thomas, Kahle, Philipp J.
Published in Cellular signalling (01.05.2010)
Published in Cellular signalling (01.05.2010)
Get full text
Journal Article
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2
Troxler, Thomas, Greenidge, Paulette, Zimmermann, Kaspar, Desrayaud, Sandrine, Drückes, Peter, Schweizer, Tatjana, Stauffer, Daniela, Rovelli, Giorgio, Shimshek, Derya R.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease
Vitte, Jérémie, Traver, Sabine, Maués De Paula, André, Lesage, Suzanne, Rovelli, Giorgio, Corti, Olga, Duyckaerts, Charles, Brice, Alexis
Published in Journal of neuropathology and experimental neurology (01.09.2010)
Published in Journal of neuropathology and experimental neurology (01.09.2010)
Get full text
Journal Article
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function
Galvez, Thierry, Duthey, Béatrice, Kniazeff, Julie, Blahos, Jaroslav, Rovelli, Giorgio, Bettler, Bernhard, Prézeau, Laurent, Pin, Jean-Philippe
Published in The EMBO journal (01.05.2001)
Published in The EMBO journal (01.05.2001)
Get full text
Journal Article
Transphosphorylation of the Neurotrophin Trk Receptors (∗)
Canossa, Marco, Rovelli, Giorgio, Shooter, Eric M.
Published in The Journal of biological chemistry (08.03.1996)
Published in The Journal of biological chemistry (08.03.1996)
Get full text
Journal Article
Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1
Rovelli, Giorgio, Stone, Stuart R, Guidolin, Angelo, Sommer, Juerg, Monard, Denis
Published in Biochemistry (Easton) (07.04.1992)
Published in Biochemistry (Easton) (07.04.1992)
Get full text
Journal Article
C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABAB Receptors
Pagano, Adriana, Rovelli, Giorgio, Mosbacher, Johannes, Lohmann, Tania, Duthey, Beatrice, Stauffer, Daniela, Ristig, Dorothee, Schuler, Valerie, Meigel, Ingeborg, Lampert, Christina, Stein, Thomas, Prezeau, Laurent, Blahos, Jaroslav, Pin, Jean-Philippe, Froestl, Wolfgang, Kuhn, Rainer, Heid, Jakob, Kaupmann, Klemens, Bettler, Bernhard
Published in The Journal of neuroscience (15.02.2001)
Published in The Journal of neuroscience (15.02.2001)
Get full text
Journal Article
Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors
Weihofen, Andreas, Lemberg, Marius K., Friedmann, Elena, Rueeger, Heinrich, Schmitz, Albert, Paganetti, Paolo, Rovelli, Giorgio, Martoglio, Bruno
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
Get full text
Journal Article
Part I: Parkin-associated proteins and Parkinson’s disease
Dev, Kumlesh K., van der Putten, Herman, Sommer, Bernd, Rovelli, Giorgio
Published in Neuropharmacology (01.07.2003)
Published in Neuropharmacology (01.07.2003)
Get full text
Book Review
Journal Article
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals
Dev, Kumlesh K., Chatterjee, Sandipan, Osinde, Maribel, Stauffer, Daniela, Morgan, Hannah, Kobialko, Monika, Dengler, Uwe, Rueeger, Heinrich, Martoglio, Bruno, Rovelli, Giorgio
Published in European journal of pharmacology (01.07.2006)
Published in European journal of pharmacology (01.07.2006)
Get full text
Journal Article