Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors
Noberini, Roberta, Koolpe, Mitchell, Peddibhotla, Satyamaheshwar, Dahl, Russell, Su, Ying, Cosford, Nicholas D.P., Roth, Gregory P., Pasquale, Elena B.
Published in The Journal of biological chemistry (24.10.2008)
Published in The Journal of biological chemistry (24.10.2008)
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Dual neuroprotective pathways of a pro‐electrophilic compound via HSF‐1‐activated heat‐shock proteins and Nrf2‐activated phase 2 antioxidant response enzymes
Satoh, Takumi, Rezaie, Tayebeh, Seki, Masaaki, Sunico, Carmen R., Tabuchi, Takahito, Kitagawa, Tomomi, Yanagitai, Mika, Senzaki, Mutsumi, Kosegawa, Chihiro, Taira, Hideharu, McKercher, Scott R., Hoffman, Jennifer K., Roth, Gregory P., Lipton, Stuart A.
Published in Journal of neurochemistry (01.11.2011)
Published in Journal of neurochemistry (01.11.2011)
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Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
Maloney, Patrick R., Khan, Pasha, Hedrick, Michael, Gosalia, Palak, Milewski, Monika, Li, Linda, Roth, Gregory P., Sergienko, Eduard, Suyama, Eigo, Sugarman, Eliot, Nguyen, Kevin, Mehta, Alka, Vasile, Stefan, Su, Ying, Stonich, Derek, Nguyen, Hung, Zeng, Fu-Yue, Novo, Arianna Mangravita, Vicchiarelli, Michael, Diwan, Jena, Chung, Thomas D.Y., Smith, Layton H., Pinkerton, Anthony B.
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
Satoh, Takumi, Stalder, Romain, McKercher, Scott R., Williamson, Robert E., Roth, Gregory P., Lipton, Stuart A.
Published in ASN neuro (01.07.2015)
Published in ASN neuro (01.07.2015)
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Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins
Hassig, Christian A, Zeng, Fu-Yue, Kung, Paul, Kiankarimi, Mehrak, Kim, Sylvia, Diaz, Paul W, Zhai, Dayong, Welsh, Kate, Morshedian, Shana, Su, Ying, O'Keefe, Barry, Newman, David J, Rusman, Yudi, Kaur, Harneet, Salomon, Christine E, Brown, Susan G, Baire, Beeraiah, Michel, Andrew R, Hoye, Thomas R, Francis, Subhashree, Georg, Gunda I, Walters, Michael A, Divlianska, Daniela B, Roth, Gregory P, Wright, Amy E, Reed, John C
Published in Journal of biomolecular screening (01.09.2014)
Published in Journal of biomolecular screening (01.09.2014)
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Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Hershberger, Paul M, Peddibhotla, Satyamaheshwar, Sessions, E Hampton, Divlianska, Daniela B, Correa, Ricardo G, Pinkerton, Anthony B, Reed, John C, Roth, Gregory P
Published in Beilstein journal of organic chemistry (08.05.2013)
Published in Beilstein journal of organic chemistry (08.05.2013)
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Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead
Moriarty, Kevin J., Winters, Michael, Qiao, Lei, Ryan, Declan, DesJarlis, Renee, Robinson, Darius, Cook, Brian N., Kashem, Mohammed A., Kaplita, Paul V., Liu, Lisa H., Farrell, Thomas M., Khine, Hnin Hnin, King, Josephine, Pullen, Steven S., Roth, Gregory P., Magolda, Ronald, Takahashi, Hidenori
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
Ahn, Byungyong, Soundarapandian, Mangala M, Sessions, Hampton, Peddibhotla, Satyamaheshwar, Roth, Gregory P, Li, Jian-Liang, Sugarman, Eliot, Koo, Ada, Malany, Siobhan, Wang, Miao, Yea, Kyungmoo, Brooks, Jeanne, Leone, Teresa C, Han, Xianlin, Vega, Rick B, Kelly, Daniel P
Published in The Journal of clinical investigation (01.09.2016)
Published in The Journal of clinical investigation (01.09.2016)
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Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors
Lechtenberg, Bernhard C, Mace, Peter D, Sessions, E. Hampton, Williamson, Robert, Stalder, Romain, Wallez, Yann, Roth, Gregory P, Riedl, Stefan J, Pasquale, Elena B
Published in ACS medicinal chemistry letters (13.07.2017)
Published in ACS medicinal chemistry letters (13.07.2017)
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Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6‑phosphogluconolactonase Inhibitor (R,Z)‑N‑((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro‑2H‑benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro
Preuss, Janina, Maloney, Patrick, Peddibhotla, Satyamaheshwar, Hedrick, Michael P, Hershberger, Paul, Gosalia, Palak, Milewski, Monika, Li, Yujie Linda, Sugarman, Eliot, Hood, Becky, Suyama, Eigo, Nguyen, Kevin, Vasile, Stefan, Sergienko, Eduard, Mangravita-Novo, Arianna, Vicchiarelli, Michael, McAnally, Danielle, Smith, Layton H, Roth, Gregory P, Diwan, Jena, Chung, Thomas D.Y, Jortzik, Esther, Rahlfs, Stefan, Becker, Katja, Pinkerton, Anthony B, Bode, Lars
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Journal Article
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
Khan, Pasha M, Correa, Ricardo G, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Sessions, E. Hampton, Magnuson, Gavin, Brown, Brock, Suyama, Eigo, Yuan, Hongbin, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Su, Ying, Vasile, Stefan, Smith, Layton H, Diaz, Paul W, Reed, John C, Roth, Gregory P
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Journal Article
Imidazole-derived agonists for the neurotensin 1 receptor
Hershberger, Paul M., Hedrick, Michael P., Peddibhotla, Satyamaheshwar, Mangravita-Novo, Arianna, Gosalia, Palak, Li, Yujie, Gray, Wilson, Vicchiarelli, Michael, Smith, Layton H., Chung, Thomas D. Y., Thomas, James B., Caron, Marc G., Pinkerton, Anthony B., Barak, Lawrence S., Roth, Gregory P.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Journal Article
Discovery of ML314, a Brain Penetrant Nonpeptidic β‑Arrestin Biased Agonist of the Neurotensin NTR1 Receptor
Peddibhotla, Satyamaheshwar, Hedrick, Michael P, Hershberger, Paul, Maloney, Patrick R, Li, Yujie, Milewski, Monika, Gosalia, Palak, Gray, Wilson, Mehta, Alka, Sugarman, Eliot, Hood, Becky, Suyama, Eigo, Nguyen, Kevin, Heynen-Genel, Susanne, Vasile, Stefan, Salaniwal, Sumeet, Stonich, Derek, Su, Ying, Mangravita-Novo, Arianna, Vicchiarelli, Michael, Roth, Gregory P, Smith, Layton H, Chung, Thomas D. Y, Hanson, Glen R, Thomas, James B, Caron, Marc G, Barak, Lawrence S, Pinkerton, Anthony B
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
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Exploratory analysis of kinetic solubility measurements of a small molecule library
Guha, Rajarshi, Dexheimer, Thomas S., Kestranek, Aimee N., Jadhav, Ajit, Chervenak, Andrew M., Ford, Michael G., Simeonov, Anton, Roth, Gregory P., Thomas, Craig J.
Published in Bioorganic & medicinal chemistry (01.07.2011)
Published in Bioorganic & medicinal chemistry (01.07.2011)
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