Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Nintedanib: From Discovery to the Clinic
Roth, Gerald J, Binder, Rudolf, Colbatzky, Florian, Dallinger, Claudia, Schlenker-Herceg, Rozsa, Hilberg, Frank, Wollin, Stefan-Lutz, Kaiser, Rolf
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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Bortezomib, Dexamethasone, and Fibroblast Growth Factor Receptor 3–Specific Tyrosine Kinase Inhibitor in t(4;14) Myeloma
BISPING, Guido, WENNING, Doris, VOLPERT, Sarah, MESTERS, Rolf M, BERDEL, Wolfgang E, KIENAST, Joachim, KROPFF, Martin, GUSTAVUS, Dirk, MÜLLER-TIDOW, Carsten, STELLJES, Matthias, MUNZERT, Gerd, HILBERG, Frank, ROTH, Gerald J, STEFANIC, Martin
Published in Clinical cancer research (15.01.2009)
Published in Clinical cancer research (15.01.2009)
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BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
Hilberg, Frank, Roth, Gerald J, Krssak, Martin, Kautschitsch, Susanna, Sommergruber, Wolfgang, Tontsch-Grunt, Ulrike, Garin-Chesa, Pilar, Bader, Gerd, Zoephel, Andreas, Quant, Jens, Heckel, Armin, Rettig, Wolfgang J
Published in Cancer research (Chicago, Ill.) (15.06.2008)
Published in Cancer research (Chicago, Ill.) (15.06.2008)
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Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization
Baum, Patrick, Schmid, Ramona, Ittrich, Carina, Rust, Werner, Fundel-Clemens, Katrin, Siewert, Susanne, Baur, Martin, Mara, Lisa, Gruenbaum, Lore, Heckel, Armin, Eils, Roland, Kontermann, Roland E, Roth, Gerald J, Gantner, Florian, Schnapp, Andreas, Park, John E, Weith, Andreas, Quast, Karsten, Mennerich, Detlev
Published in PloS one (10.12.2010)
Published in PloS one (10.12.2010)
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Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
Lok, Si, Kaushansky, Kenneth, Holly, Richard D, Kuijper, Joseph L, Lofton-Day, Catherine E, Oort, Pieter J, Grant, Francis J, Heipel, Mark D, Burkhead, Steve K, Kramer, Janet M, Bell, L. Anne, Sprecher, Cindy A, Blumberg, Hal, Johnson, Rebecca, Prunkard, Donna, Ching, Andrew F. T, Mathewes, Shannon L, Bailey, Mason C, Forstrom, John W, Buddle, Michele M, Osborn, Sherri G, Evans, Simon J, Sheppard, Paul O, Presnell, Scott R, O'Hara, Patrick J, Hagen, Fredrick S, Roth, Gerald J, Foster, Donald C
Published in Nature (London) (16.06.1994)
Published in Nature (London) (16.06.1994)
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Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
Kaushansky, Kenneth, Lok, Si, Holly, Richard D, Broudy, Virginia C, Lin, Nancy, Bailey, Mason C, Forstrom, John W, Buddle, Michele M, Oort, Pieter J, Hagen, Fredrick S, Roth, Gerald J, Papayannopoulou, Thalia, Foster, Donald C
Published in Nature (London) (16.06.1994)
Published in Nature (London) (16.06.1994)
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Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors
Kulimova, Emma, Oelmann, Elisabeth, Bisping, Guido, Kienast, Joachim, Mesters, Rolf M., Schwäble, Joachim, Hilberg, Frank, Roth, Gerald J., Munzert, Gerd, Stefanic, Martin, Steffen, Björn, Brandts, Christian, Müller-Tidow, Carsten, Kolkmeyer, Astrid, Büchner, Thomas, Serve, Hubert, Berdel, Wolfgang E.
Published in Molecular cancer therapeutics (01.12.2006)
Published in Molecular cancer therapeutics (01.12.2006)
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Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo
Kuttruff, Christian A, Ferrara, Marco, Bretschneider, Tom, Hoerer, Stefan, Handschuh, Sandra, Nosse, Bernd, Romig, Helmut, Nicklin, Paul, Roth, Gerald J
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Design, Synthesis, and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor β Receptor I (TGFβRI)
Roth, Gerald J, Heckel, Armin, Brandl, Trixi, Grauert, Matthias, Hoerer, Stefan, Kley, Joerg T, Schnapp, Gisela, Baum, Patrick, Mennerich, Detlev, Schnapp, Andreas, Park, John E
Published in Journal of medicinal chemistry (28.10.2010)
Published in Journal of medicinal chemistry (28.10.2010)
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The Oncogenic TLS-ERG Fusion Protein Exerts Different Effects in Hematopoietic Cells and Fibroblasts
Zou, Junhui, Ichikawa, Hitoshi, Blackburn, Michael L., Hu, Hsien-Ming, Zielinska-Kwiatkowska, Anna, Mei, Qi, Roth, Gerald J., Chansky, Howard A., Yang, Liu
Published in Molecular and Cellular Biology (01.07.2005)
Published in Molecular and Cellular Biology (01.07.2005)
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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908
Oost, Thorsten, Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition
Roth, Gerald J., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan G., Oost, Thorsten, Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Schindler, Marcus, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414
Müller, Stephan G., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Lustenberger, Philipp, Oost, Thorsten, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Schindler, Marcus, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Paracrine interactions of vascular endothelial growth factor and platelet-derived growth factor in endothelial and lung cancer cells
REINMUTH, Niels, RENSINGHOFF, Sonja, THOMAS, Michael, MESTERS, Rolf M, RAEDEL, Miriam, FEHRMANN, Nicole, SCHWÖPPE, Christian, KESSLER, Torsten, BISPING, Guido, HILBERG, Frank, ROTH, Gerald J, BERDEL, Wolfgang
Published in International journal of oncology (01.09.2007)
Published in International journal of oncology (01.09.2007)
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Localization of binding sites within human von Willebrand factor for monomeric type III collagen
Roth, Gerald J, Titani, Koiti, Hoyer, Leon W, Hickey, Mark J
Published in Biochemistry (Easton) (01.12.1986)
Published in Biochemistry (Easton) (01.12.1986)
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Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups
Bisping, Guido, Kropff, Martin, Wenning, Doris, Dreyer, Britta, Bessonov, Sergey, Hilberg, Frank, Roth, Gerald J., Munzert, Gerd, Stefanic, Martin, Stelljes, Matthias, Scheffold, Christian, Müller-Tidow, Carsten, Liebisch, Peter, Lang, Nicola, Tchinda, Jöelle, Serve, Hubert L., Mesters, Rolf M., Berdel, Wolfgang E., Kienast, Joachim
Published in Blood (01.03.2006)
Published in Blood (01.03.2006)
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