Structure-based discovery of opioid analgesics with reduced side effects
Manglik, Aashish, Lin, Henry, Aryal, Dipendra K, McCorvy, John D, Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C, Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F, Giguère, Patrick M, Löber, Stefan, Da Duan, Scherrer, Grégory, Kobilka, Brian K, Gmeiner, Peter, Roth, Bryan L, Shoichet, Brian K
Published in Nature (London) (08.09.2016)
Published in Nature (London) (08.09.2016)
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Journal Article
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.
Published in Cell (11.01.2018)
Published in Cell (11.01.2018)
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Journal Article
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
Peng, Yao, McCorvy, John D., Harpsøe, Kasper, Lansu, Katherine, Yuan, Shuguang, Popov, Petr, Qu, Lu, Pu, Mengchen, Che, Tao, Nikolajsen, Louise F., Huang, Xi-Ping, Wu, Yiran, Shen, Ling, Bjørn-Yoshimoto, Walden E., Ding, Kang, Wacker, Daniel, Han, Gye Won, Cheng, Jianjun, Katritch, Vsevolod, Jensen, Anders A., Hanson, Michael A., Zhao, Suwen, Gloriam, David E., Roth, Bryan L., Stevens, Raymond C., Liu, Zhi-Jie
Published in Cell (08.02.2018)
Published in Cell (08.02.2018)
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Journal Article
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
Neumaier, John F, Ferguson, Susan M, Eskenazi, Daniel, Ishikawa, Masago, Wanat, Matthew J, Phillips, Paul E M, Dong, Yan, Roth, Bryan L
Published in Nature neuroscience (01.01.2011)
Published in Nature neuroscience (01.01.2011)
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Journal Article
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace
Baumann, Michael H., Majumdar, Susruta, Le Rouzic, Valerie, Hunkele, Amanda, Uprety, Rajendra, Huang, Xi Ping, Xu, Jin, Roth, Bryan L., Pan, Ying-Xian, Pasternak, Gavril W.
Published in Neuropharmacology (15.05.2018)
Published in Neuropharmacology (15.05.2018)
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Journal Article
Translating genome-wide association findings into new therapeutics for psychiatry
Breen, Gerome, Li, Qingqin, Roth, Bryan L, O'Donnell, Patricio, Didriksen, Michael, Dolmetsch, Ricardo, O'Reilly, Paul F, Gaspar, Héléna A, Manji, Husseini, Huebel, Christopher, Kelsoe, John R, Malhotra, Dheeraj, Bertolino, Alessandro, Posthuma, Danielle, Sklar, Pamela, Kapur, Shitij, Sullivan, Patrick F, Collier, David A, Edenberg, Howard J
Published in Nature neuroscience (01.11.2016)
Published in Nature neuroscience (01.11.2016)
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Journal Article
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Urban, Jonathan D, Clarke, William P, von Zastrow, Mark, Nichols, David E, Kobilka, Brian, Weinstein, Harel, Javitch, Jonathan A, Roth, Bryan L, Christopoulos, Arthur, Sexton, Patrick M, Miller, Keith J, Spedding, Michael, Mailman, Richard B
Published in The Journal of pharmacology and experimental therapeutics (01.01.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2007)
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Journal Article
Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats
Marchant, Nathan J, Whitaker, Leslie R, Bossert, Jennifer M, Harvey, Brandon K, Hope, Bruce T, Kaganovsky, Konstantin, Adhikary, Sweta, Prisinzano, Thomas E, Vardy, Eyal, Roth, Bryan L, Shaham, Yavin
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2016)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2016)
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Journal Article
HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
KROEZE, Wesley K, HUFEISEN, Sandra J, POPADAK, Beth A, RENOCK, Sean M, STEINBERG, Seanna, ERNSBERGER, Paul, JAYATHILAKE, Karu, MELTZER, Herbert Y, ROTH, Bryan L
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2003)
Published in Neuropsychopharmacology (New York, N.Y.) (01.03.2003)
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Journal Article
G-protein-coupled receptors at a glance
Kroeze, Wesley K, Sheffler, Douglas J, Roth, Bryan L
Published in Journal of cell science (15.12.2003)
Published in Journal of cell science (15.12.2003)
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Journal Article
Salvinorin A: A Potent Naturally Occurring Nonnitrogenous κ Opioid Selective Agonist
Roth, Bryan L., Baner, Karen, Westkaemper, Richard, Siebert, Daniel, Rice, Kenner C., Steinberg, SeAnna, Ernsberger, Paul, Rothman, Richard B.
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2002)
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Journal Article
The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells
Elphick, Gwendolyn F., Querbes, William, Jordan, Joslynn A., Gee, Gretchen V., Eash, Sylvia, Manley, Kate, Dugan, Aisling, Stanifer, Megan, Bhatnagar, Anushree, Kroeze, Wesley K., Roth, Bryan L., Atwood, Walter J.
Published in Science (American Association for the Advancement of Science) (19.11.2004)
Published in Science (American Association for the Advancement of Science) (19.11.2004)
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