Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo
O'Brien, Patrick M, Sliskovic, Drago R, Blankley, C. John, Roth, Bruce. D, Wilson, Michael W, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L
Published in Journal of medicinal chemistry (01.06.1994)
Published in Journal of medicinal chemistry (01.06.1994)
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Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series
Song, Yuntao, Connor, David T, Sercel, Anthony D, Sorenson, Roderick J, Doubleday, Robert, Unangst, Paul C, Roth, Bruce D, Beylin, Vlad G, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Structure−Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors
O'Brien, Patrick M, Ortwine, Daniel F, Pavlovsky, Alexander G, Picard, Joseph A, Sliskovic, Drago R, Roth, Bruce D, Dyer, Richard D, Johnson, Linda L, Man, Chiu Fai, Hallak, Hussein
Published in Journal of medicinal chemistry (27.01.2000)
Published in Journal of medicinal chemistry (27.01.2000)
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Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor
Li, Jie Jack, Carson, Kenneth G, Trivedi, Bharat K, Yue, Wen Song, Ye, Qing, Glynn, Roberta A, Miller, Steven R, Connor, David T, Roth, Bruce D, Luly, Jay R, Low, Joseph E, Heilig, David J, Yang, Weixing, Qin, Shixin, Hunt, Stephen
Published in Bioorganic & medicinal chemistry (15.08.2003)
Published in Bioorganic & medicinal chemistry (15.08.2003)
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Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series
Song, Yuntao, Connor, David T, Doubleday, Robert, Sorenson, Roderick J, Sercel, Anthony D, Unangst, Paul C, Roth, Bruce D, Gilbertsen, Richard B, Chan, Kam, Schrier, Denis J, Guglietta, Antonio, Bornemeier, Dirk A, Dyer, Richard D
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists
Padia, Janak K, Field, Mark, Hinton, Joanna, Meecham, Ken, Pablo, Julius, Pinnock, Rob, Roth, Bruce D, Singh, Lakhbir, Suman-Chauhan, Nirmala, Trivedi, Bharat K, Webdale, Louise
Published in Journal of medicinal chemistry (26.03.1998)
Published in Journal of medicinal chemistry (26.03.1998)
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Metabolism and Excretion of Atorvastatin in Rats And Dogs
BLACK, A. E, HAYES, R. N, ROTH, B. D, WOO, P, WOOLF, T. F
Published in Drug metabolism and disposition (01.08.1999)
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Published in Drug metabolism and disposition (01.08.1999)
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X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity
PAVLOVSKY, ALEXANDER G., WILLIAMS, MARK G., YE, QI-ZHUANG, ORTWINE, DANIEL F., PURCHASE, CLAUDE F., WHITE, ANDREW D., DHANARAJ, V., ROTH, BRUCE D., JOHNSON, LINDA L., HUPE, DONALD, HUMBLET, CHRISTINE, BLUNDELL, TOM L.
Published in Protein science (01.07.1999)
Published in Protein science (01.07.1999)
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Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. CI-1011: An Acyl Sulfamate with Unique Cholesterol-Lowering Activity in Animals Fed Noncholesterol-Supplemented Diets
Lee, Helen T., Sliskovic, Drago R., Picard, Joseph A., Roth, Bruce D., Wierenga, Wendell, Hicks, James L., Bousley, Richard F., Hamelehle, Katherine L., Homan, Reynold, Speyer, Cecilia, Stanfield, Richard L., Krause, Brian R.
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Inhibitors of lipoprotein(a) assembly
Sexton, Karen E, Lee, Helen T, Massa, Mark, Padia, Janak, Patt, William C, Liao, Peggy, Pontrello, Jason K, Roth, Bruce D, Spahr, Mark A, Ramharack, Randy
Published in Bioorganic & medicinal chemistry (03.11.2003)
Published in Bioorganic & medicinal chemistry (03.11.2003)
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A simple method for preparation of N-mono- and N, N-di-alkylated α-amino acids
Song, Yuntao, Sercel, Anthony D., Johnson, Don R., Colbry, Norman L., Sun, Kuai-Lin, Roth, Bruce D.
Published in Tetrahedron letters (21.10.2000)
Published in Tetrahedron letters (21.10.2000)
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(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain
Song, Yuntao, Bowersox, S. Scott, Connor, David T, Dooley, David J, Lotarski, Susan M, Malone, Thomas, Miljanich, George, Millerman, Elizabeth, Rafferty, Michael F, Rock, David, Roth, Bruce D, Schmidt, Joann, Stoehr, Sally, Szoke, Balazs G, Taylor, Charles, Vartanian, Mark, Wang, Yong-Xiang
Published in Journal of medicinal chemistry (21.09.2000)
Published in Journal of medicinal chemistry (21.09.2000)
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Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation
Bocan, Thomas M.A., Mazur, Michelle J., Bak Mueller, Sandra, Brown, Edie Quenby, Sliskovic, D.Robert, O'Brien, Patrick M., Creswell, Mark W., Lee, Helen, Uhlendorf, Paul D., Roth, Bruce D., Newton, Roger S.
Published in Atherosclerosis (01.11.1994)
Published in Atherosclerosis (01.11.1994)
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Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents
Roth, Bruce D, Blankley, C. John, Hoefle, Milton L, Holmes, Ann, Roark, W. Howard, Trivedi, Bharat K, Essenburg, Arnold D, Kieft, Karen A, Krause, Brian R, Stanfield, Richard L
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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THE SYNTHESIS OF (4R-CIS)-1,1-DIMETHYLETHYL 6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE, A KEY INTERMEDIATE FOR THE PREPARATION OF CI-981, A HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE
BROWER, PL, BUTLER, DE, DEERING, CF, LE, TV, MILLAR, A, NANNINGA, TN, ROTH, BD
Published in Tetrahedron letters (01.04.1992)
Published in Tetrahedron letters (01.04.1992)
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Synthesis of novel 3-and 5-substituted indole-2-carboxamides
Bratton, LD, Roth, BD, Trivedi, BK, Unangst, PC
Published in Journal of heterocyclic chemistry (01.09.2000)
Published in Journal of heterocyclic chemistry (01.09.2000)
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