Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul
Published in Nature biotechnology (01.08.2008)
Published in Nature biotechnology (01.08.2008)
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Journal Article
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
CAREY, Kendall D, GARTON, Andrew J, ROMERO, Maria S, KAHLER, Jennifer, THOMSON, Stuart, ROSS, Sarajane, PARK, Frances, HALEY, John D, GIBSON, Neil, SLIWKOWSKI, Mark X
Published in Cancer research (Chicago, Ill.) (15.08.2006)
Published in Cancer research (Chicago, Ill.) (15.08.2006)
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Journal Article
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
Jin, Hongkui, Yang, Renhui, Zheng, Zhong, Romero, Mally, Ross, Jed, Bou-Reslan, Hani, Carano, Richard A D, Kasman, Ian, Mai, Elaine, Young, Judy, Zha, Jiping, Zhang, Zemin, Ross, Sarajane, Schwall, Ralph, Colbern, Gail, Merchant, Mark
Published in Cancer research (Chicago, Ill.) (01.06.2008)
Published in Cancer research (Chicago, Ill.) (01.06.2008)
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Journal Article
Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma
Polson, Andrew G., Yu, Shang-Fan, Elkins, Kristi, Zheng, Bing, Clark, Suzanna, Ingle, Gladys S., Slaga, Dionysos S., Giere, Lynne, Du, Changchun, Tan, Christine, Hongo, Jo-Anne, Gogineni, Alvin, Cole, Mary J., Vandlen, Richard, Stephan, Jean-Philippe, Young, Judy, Chang, Wesley, Scales, Suzie J., Ross, Sarajane, Eaton, Dan, Ebens, Allen
Published in Blood (15.07.2007)
Published in Blood (15.07.2007)
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Journal Article
Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma
Strickland, Laura A, Ross, Jed, Williams, Simon, Ross, Sarajane, Romero, Maria, Spencer, Susan, Erickson, Rich, Sutcliffe, Julie, Verbeke, Caroline, Polakis, Paul, van Bruggen, Nicholas, Koeppen, Hartmut
Published in The Journal of pathology (01.07.2009)
Published in The Journal of pathology (01.07.2009)
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Journal Article
EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer
WEIGUANG MAO, LUIS, Elizabeth, POLAKIS, Paul, ROSS, Sarajane, SILVA, Johnny, TAN, Christine, CROWLEY, Craig, CHUI, Clarissa, FRANZ, Gretchen, SENTER, Peter, KOEPPEN, Hartmut
Published in Cancer research (Chicago, Ill.) (01.02.2004)
Published in Cancer research (Chicago, Ill.) (01.02.2004)
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Journal Article
Mapping In Vivo Tumor Oxygenation within Viable Tumor by 19F-MRI and Multispectral Analysis
Shi, Yunzhou, Oeh, Jason, Eastham-Anderson, Jeffrey, Yee, Sharon, Finkle, David, Peale, Franklin V., Ross, Jed, Hedehus, Maj, van Bruggen, Nicholas, Venook, Rayna, Ross, Sarajane, Sampath, Deepak, Carano, Richard A.D.
Published in Neoplasia (New York, N.Y.) (01.11.2013)
Published in Neoplasia (New York, N.Y.) (01.11.2013)
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Journal Article
Inhibition of Epithelial Ductal Branching in the Prostate by Sonic Hedgehog Is Indirectly Mediated by Stromal Cells
Wang, Bu-Er, Shou, Jianyong, Ross, Sarajane, Koeppen, Hartmut, De Sauvage, Frederic J, Gao, Wei-Qiang
Published in The Journal of biological chemistry (16.05.2003)
Published in The Journal of biological chemistry (16.05.2003)
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Journal Article
Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake
Shang, Yonglei, Mao, Yifan, Batson, Jennifer, Scales, Suzie J, Phillips, Gail, Lackner, Mark R, Totpal, Klara, Williams, Simon, Yang, Jihong, Tang, Zhijun, Modrusan, Zora, Tan, Christine, Liang, Wei-Ching, Tsai, Siao Ping, Vanderbilt, Alexander, Kozuka, Kenji, Hoeflich, Klaus, Tien, Janet, Ross, Sarajane, Li, Congfen, Lee, Sang Hoon, Song, An, Wu, Yan, Stephan, Jean-Philippe, Ashkenazi, Avi, Zha, Jiping
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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Journal Article
Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1
Lewis, M T, Ross, S, Strickland, P A, Sugnet, C W, Jimenez, E, Scott, M P, Daniel, C W
Published in Development (Cambridge) (15.11.1999)
Published in Development (Cambridge) (15.11.1999)
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Journal Article
Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
Bostrom, Jenny, Yu, Shang-Fan, Kan, David, Appleton, Brent A, Lee, Chingwei V, Billeci, Karen, Man, Wenyan, Peale, Franklin, Ross, Sarajane, Wiesmann, Christian, Fuh, Germaine
Published in Science (American Association for the Advancement of Science) (20.03.2009)
Published in Science (American Association for the Advancement of Science) (20.03.2009)
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Journal Article
An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells
Wilson, Nicholas S., Yang, Becky, Yang, Annie, Loeser, Stefanie, Marsters, Scot, Lawrence, David, Li, Yun, Pitti, Robert, Totpal, Klara, Yee, Sharon, Ross, Sarajane, Vernes, Jean-Michel, Lu, Yanmei, Adams, Cam, Offringa, Rienk, Kelley, Bob, Hymowitz, Sarah, Daniel, Dylan, Meng, Gloria, Ashkenazi, Avi
Published in Cancer cell (18.01.2011)
Published in Cancer cell (18.01.2011)
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Journal Article
Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth
Pan, Qi, Chanthery, Yvan, Liang, Wei-Ching, Stawicki, Scott, Mak, Judy, Rathore, Nisha, Tong, Raymond K., Kowalski, Joe, Yee, Sharon Fong, Pacheco, Glenn, Ross, Sarajane, Cheng, Zhiyong, Le Couter, Jennifer, Plowman, Greg, Peale, Franklin, Koch, Alexander W., Wu, Yan, Bagri, Anil, Tessier-Lavigne, Marc, Watts, Ryan J.
Published in Cancer cell (2007)
Published in Cancer cell (2007)
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Journal Article
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Qing, Jing, Du, Xiangnan, Chen, Yongmei, Chan, Pamela, Li, Hao, Wu, Ping, Marsters, Scot, Stawicki, Scott, Tien, Janet, Totpal, Klara, Ross, Sarajane, Stinson, Susanna, Dornan, David, French, Dorothy, Wang, Qian-Rena, Stephan, Jean-Philippe, Wu, Yan, Wiesmann, Christian, Ashkenazi, Avi
Published in The Journal of clinical investigation (01.05.2009)
Published in The Journal of clinical investigation (01.05.2009)
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Journal Article
Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast
Lewis, M T, Ross, S, Strickland, P A, Snyder, C J, Daniel, C W
Published in Cell and tissue research (01.06.1999)
Published in Cell and tissue research (01.06.1999)
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Journal Article
Imaging tumors with an albumin-binding fab, a novel tumor-targeting agent
DENNIS, Mark S, HONGKUI JIN, DUGGER, Debra, RENHUI YANG, MCFARLAND, Leanne, OGASAWARA, Annie, WILLIAMS, Simon, COLE, Mary J, ROSS, Sarajane, SCHWALL, Ralph
Published in Cancer research (Chicago, Ill.) (2007)
Published in Cancer research (Chicago, Ill.) (2007)
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Journal Article
An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models
Scales, Suzie J, Gupta, Nidhi, Pacheco, Glenn, Firestein, Ron, French, Dorothy M, Koeppen, Hartmut, Rangell, Linda, Barry-Hamilton, Vivian, Luis, Elizabeth, Chuh, Josefa, Zhang, Yin, Ingle, Gladys S, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Ross, Sarajane, Dennis, Mark S, Spencer, Susan D
Published in Molecular cancer therapeutics (01.11.2014)
Published in Molecular cancer therapeutics (01.11.2014)
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Journal Article
Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model
Pastuskovas, Cinthia V, Mundo, Eduardo E, Williams, Simon P, Nayak, Tapan K, Ho, Jason, Ulufatu, Sheila, Clark, Suzanna, Ross, Sarajane, Cheng, Eric, Parsons-Reponte, Kathryn, Cain, Gary, Van Hoy, Marjie, Majidy, Nicholas, Bheddah, Sheila, dela Cruz Chuh, Josefa, Kozak, Katherine R, Lewin-Koh, Nicholas, Nauka, Peter, Bumbaca, Daniela, Sliwkowski, Mark, Tibbitts, Jay, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Boswell, C Andrew
Published in Molecular cancer therapeutics (01.03.2012)
Published in Molecular cancer therapeutics (01.03.2012)
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