A Chemical Approach to Introduce 2,6-Diaminopurine and 2‑Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups
Madaoui, Mimouna, Datta, Dhrubajyoti, Wassarman, Kelly, Zlatev, Ivan, Egli, Martin, Ross, Bruce S., Manoharan, Muthiah
Published in Organic letters (26.08.2022)
Published in Organic letters (26.08.2022)
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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina
Published in Nature (London) (17.03.2016)
Published in Nature (London) (17.03.2016)
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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates
Ross, Bruce S, Ganapati Reddy, P, Zhang, Hai-Ren, Rachakonda, Suguna, Sofia, Michael J
Published in Journal of organic chemistry (21.10.2011)
Published in Journal of organic chemistry (21.10.2011)
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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase
Wang, Peiyuan, Chun, Byoung-Kwon, Rachakonda, Suguna, Du, Jinfa, Khan, Noshena, Shi, Junxing, Stec, Wojciech, Cleary, Darryl, Ross, Bruce S, Sofia, Michael J
Published in Journal of organic chemistry (04.09.2009)
Published in Journal of organic chemistry (04.09.2009)
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Stereoselective Synthesis of PSI-352938: A β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV
Reddy, P. Ganapati, Chun, Byoung-Kwon, Zhang, Hai-Ren, Rachakonda, Suguna, Ross, Bruce S, Sofia, Michael J
Published in Journal of organic chemistry (20.05.2011)
Published in Journal of organic chemistry (20.05.2011)
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Characteristics of lower extremity clonus after human cervical spinal cord injury
Wallace, Douglas M, Ross, Bruce H, Thomas, Christine K
Published in Journal of neurotrauma (20.03.2012)
Published in Journal of neurotrauma (20.03.2012)
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Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides
Prakash, Thazha P, Kawasaki, Andrew M, Wancewicz, Edward V, Shen, Lijiang, Monia, Brett P, Ross, Bruce S, Bhat, Balkrishen, Manoharan, Muthiah
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2‘-O-Ribonucleic Acid Modifications
Egli, Martin, Minasov, George, Tereshko, Valentina, Pallan, Pradeep S, Teplova, Marianna, Inamati, Gopal B, Lesnik, Elena A, Owens, Steve R, Ross, Bruce S, Prakash, Thazha P, Manoharan, Muthiah
Published in Biochemistry (Easton) (28.06.2005)
Published in Biochemistry (Easton) (28.06.2005)
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2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
Reddy, P. Ganapati, Bao, Donghui, Chang, Wonsuk, Chun, Byoung-Kwon, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Ross, Bruce S., Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L., Keilman, Meg, Lam, Angela M., Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661
Furman, Phillip A., Murakami, Eisuke, Niu, Congrong, Lam, Angela M., Espiritu, Christine, Bansal, Shalini, Bao, Haiying, Tolstykh, Tatiana, Micolochick Steuer, Holly, Keilman, Meg, Zennou, Veronique, Bourne, Nigel, Veselenak, Ronald L., Chang, Wonsuk, Ross, Bruce S., Du, Jinfa, Otto, Michael J., Sofia, Michael J.
Published in Antiviral research (01.08.2011)
Published in Antiviral research (01.08.2011)
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