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Published in Nature (London) (13.02.2020)
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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
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Published in The lancet oncology (01.12.2010)
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
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Published in Cancer research (Chicago, Ill.) (01.05.2008)
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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
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Published in Journal of medicinal chemistry (13.11.2008)
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ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models
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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
TAHIR, Stephen K, XIUFEN YANG, ROSENBERG, Saul H, TSE, Christin, ANDERSON, Mark G, MORGAN-LAPPE, Susan E, SARTHY, Aparna V, JUN CHEN, WARNER, Robert B, NG, Shi-Chung, FESIK, Stephen W, ELMORE, Steve W
Published in Cancer research (Chicago, Ill.) (01.02.2007)
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Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models
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Published in Clinical cancer research (01.06.2008)
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ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors
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Published in Clinical cancer research (01.12.2009)
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The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
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Published in Cancer chemotherapy and pharmacology (01.10.2010)
Published in Cancer chemotherapy and pharmacology (01.10.2010)
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Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors
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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer
Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.08.2004)
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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR
Petros, Andrew M., Huth, Jeffrey R., Oost, Thorsten, Park, Cheol-Min, Ding, Hong, Wang, Xilu, Zhang, Haichao, Nimmer, Paul, Mendoza, Renaldo, Sun, Chaohong, Mack, Jamey, Walter, Karl, Dorwin, Sarah, Gramling, Emily, Ladror, Uri, Rosenberg, Saul H., Elmore, Steven W., Fesik, Stephen W., Hajduk, Philip J.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics
Chen, Zehan, Xiao, Zhan, Gu, Wen‐zhen, Xue, John, Bui, Mai H., Kovar, Peter, Li, Gaoquan, Wang, Gary, Tao, Zhi‐Fu, Tong, Yunsong, Lin, Nan‐Horng, Sham, Hing L., Wang, Jean Y. J., Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying
Published in International journal of cancer (15.12.2006)
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Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks
Liu, Xuesong, Shi, Yan, Guan, Ran, Donawho, Cherrie, Luo, Yanping, Palma, Joann, Zhu, Gui-Dong, Johnson, Eric F, Rodriguez, Luis E, Ghoreishi-Haack, Nayereh, Jarvis, Ken, Hradil, Vincent P, Colon-Lopez, Milagros, Cox, Bryan F, Klinghofer, Vered, Penning, Thomas, Rosenberg, Saul H, Frost, David, Giranda, Vincent L, Luo, Yan
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Published in Molecular cancer research (01.10.2008)
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ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
Ackler, Scott, Xiao, Yu, Mitten, Michael J, Foster, Kelly, Oleksijew, Anatol, Refici, Marion, Schlessinger, Sally, Wang, Baole, Chemburkar, Sanjay R, Bauch, Joy, Tse, Christin, Frost, David J, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W, Shoemaker, Alex R
Published in Molecular cancer therapeutics (01.10.2008)
Published in Molecular cancer therapeutics (01.10.2008)
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A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation
ZHAN XIAO, XUE, John, SOWIN, Thomas J, ROSENBERG, Saul H, HAIYING ZHANG
Published in Oncogene (17.02.2005)
Published in Oncogene (17.02.2005)
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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Lasko, Loren M., Jakob, Clarissa G., Edalji, Rohinton P., Qiu, Wei, Montgomery, Debra, Digiammarino, Enrico L., Hansen, T. Matt, Risi, Roberto M., Frey, Robin, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Hessler, Paul, Lam, Lloyd T., Uziel, Tamar, Faivre, Emily, Ferguson, Debra, Buchanan, Fritz G., Martin, Ruth L., Torrent, Maricel, Chiang, Gary G., Karukurichi, Kannan, Langston, J. William, Weinert, Brian T., Choudhary, Chunaram, de Vries, Peter, Kluge, Arthur F., Patane, Michael A., Van Drie, John H., Wang, Ce, McElligott, David, Kesicki, Ed, Marmorstein, Ronen, Sun, Chaohong, Cole, Philip A., Rosenberg, Saul H., Michaelides, Michael R., Lai, Albert, Bromberg, Kenneth D.
Published in Nature (London) (05.10.2017)
Published in Nature (London) (05.10.2017)
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