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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
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miR-375 maintains normal pancreatic α- and β-cell mass
Poy, Matthew N, Hausser, Jean, Trajkovski, Mirko, Braun, Matthias, Collins, Stephan, Rorsman, Patrik, Zavolan, Mihaela, Stoffel, Markus
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2009)
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A method for the generation of human stem cell-derived alpha cells
Peterson, Quinn P, Veres, Adrian, Chen, Lihua, Slama, Michael Q, Kenty, Jennifer H R, Hassoun, Shaimaa, Brown, Matthew R, Dou, Haiqiang, Duffy, Caden D, Zhou, Quan, Matveyenko, Aleksey V, Tyrberg, Björn, Sörhede-Winzell, Maria, Rorsman, Patrik, Melton, Douglas A
Published in Nature communications (07.05.2020)
Published in Nature communications (07.05.2020)
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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
Haythorne, Elizabeth, Lloyd, Matthew, Walsby-Tickle, John, Tarasov, Andrei I, Sandbrink, Jonas, Portillo, Idoia, Exposito, Raul Terron, Sachse, Gregor, Cyranka, Malgorzata, Rohm, Maria, Rorsman, Patrik, McCullagh, James, Ashcroft, Frances M
Published in Nature communications (14.11.2022)
Published in Nature communications (14.11.2022)
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α-cell glucokinase suppresses glucose-regulated glucagon secretion
Basco, Davide, Zhang, Quan, Salehi, Albert, Tarasov, Andrei, Dolci, Wanda, Herrera, Pedro, Spiliotis, Ioannis, Berney, Xavier, Tarussio, David, Rorsman, Patrik, Thorens, Bernard
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Published in Nature communications (07.02.2018)
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Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity
Philippaert, Koenraad, Pironet, Andy, Mesuere, Margot, Sones, William, Vermeiren, Laura, Kerselaers, Sara, Pinto, Sílvia, Segal, Andrei, Antoine, Nancy, Gysemans, Conny, Laureys, Jos, Lemaire, Katleen, Gilon, Patrick, Cuypers, Eva, Tytgat, Jan, Mathieu, Chantal, Schuit, Frans, Rorsman, Patrik, Talavera, Karel, Voets, Thomas, Vennekens, Rudi
Published in Nature communications (31.03.2017)
Published in Nature communications (31.03.2017)
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Voltage-Gated Ion Channels in Human Pancreatic β-Cells: Electrophysiological Characterization and Role in Insulin Secretion
Braun, Matthias, Ramracheya, Reshma, Bengtsson, Martin, Zhang, Quan, Karanauskaite, Jovita, Partridge, Chris, Johnson, Paul R, Rorsman, Patrik
Published in Diabetes (New York, N.Y.) (01.06.2008)
Published in Diabetes (New York, N.Y.) (01.06.2008)
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Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
Brereton, Melissa F, Iberl, Michaela, Shimomura, Kenju, Zhang, Quan, Adriaenssens, Alice E, Proks, Peter, Spiliotis, Ioannis I, Dace, William, Mattis, Katia K, Ramracheya, Reshma, Gribble, Fiona M, Reimann, Frank, Clark, Anne, Rorsman, Patrik, Ashcroft, Frances M
Published in Nature communications (22.08.2014)
Published in Nature communications (22.08.2014)
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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
Shigeto, Makoto, Ramracheya, Reshma, Tarasov, Andrei I, Cha, Chae Young, Chibalina, Margarita V, Hastoy, Benoit, Philippaert, Koenraad, Reinbothe, Thomas, Rorsman, Nils, Salehi, Albert, Sones, William R, Vergari, Elisa, Weston, Cathryn, Gorelik, Julia, Katsura, Masashi, Nikolaev, Viacheslav O, Vennekens, Rudi, Zaccolo, Manuela, Galione, Antony, Johnson, Paul R V, Kaku, Kohei, Ladds, Graham, Rorsman, Patrik
Published in The Journal of clinical investigation (01.12.2015)
Published in The Journal of clinical investigation (01.12.2015)
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Briant, Linford J. B., Zhang, Quan, Vergari, Elisa, Kellard, Joely A., Rodriguez, Blanca, Ashcroft, Frances M., Rorsman, Patrik
Published in Journal of the Royal Society interface (01.03.2017)
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A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
Ye, Yingying, Barghouth, Mohammad, Dou, Haiqiang, Luan, Cheng, Wang, Yongzhi, Karagiannopoulos, Alexandros, Jiang, Xiaoping, Krus, Ulrika, Fex, Malin, Zhang, Quan, Eliasson, Lena, Rorsman, Patrik, Zhang, Enming, Renström, Erik
Published in Nature communications (22.07.2022)
Published in Nature communications (22.07.2022)
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Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes
Kim, Angela, Knudsen, Jakob G, Madara, Joseph C, Benrick, Anna, Hill, Thomas G, Abdul Kadir, Lina, Kellard, Joely A, Mellander, Lisa, Miranda, Caroline, Lin, Haopeng, James, Timothy, Suba, Kinga, Spigelman, Aliya F, Wu, Yanling, MacDonald, Patrick E, Wernstedt Asterholm, Ingrid, Magnussen, Tore, Christensen, Mikkel, Vilsbøll, Tina, Salem, Victoria, Knop, Filip K, Rorsman, Patrik, Lowell, Bradford B, Briant, Linford Jb
Published in eLife (17.11.2021)
Published in eLife (17.11.2021)
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Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells
Wu, Bingbing, Wei, Shunhui, Petersen, Natalia, Ali, Yusuf, Wang, Xiaorui, Bacaj, Taulant, Rorsman, Patrik, Hong, Wanjin, Südhof, Thomas C., Han, Weiping
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
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Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes
Zhang, Quan, Ramracheya, Reshma, Lahmann, Carolina, Tarasov, Andrei, Bengtsson, Martin, Braha, Orit, Braun, Matthias, Brereton, Melissa, Collins, Stephan, Galvanovskis, Juris, Gonzalez, Alejandro, Groschner, Lukas N., Rorsman, Nils J.G., Salehi, Albert, Travers, Mary E., Walker, Jonathan N., Gloyn, Anna L., Gribble, Fiona, Johnson, Paul R.V., Reimann, Frank, Ashcroft, Frances M., Rorsman, Patrik
Published in Cell metabolism (03.12.2013)
Published in Cell metabolism (03.12.2013)
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets
Briant, Linford J.B., Dodd, Michael S., Chibalina, Margarita V., Rorsman, Nils J.G., Johnson, Paul R.V., Carmeliet, Peter, Rorsman, Patrik, Knudsen, Jakob G.
Published in Cell reports (Cambridge) (12.06.2018)
Published in Cell reports (Cambridge) (12.06.2018)
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