Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis
Poon, Michael M, Lorrain, Kym I, Stebbins, Karin J, Edu, Geraldine C, Broadhead, Alexander R, Lorenzana, Ariana J, Roppe, Jeffrey R, Baccei, Jill M, Baccei, Christopher S, Chen, Austin C, Green, Ari J, Lorrain, Daniel S, Chan, Jonah R
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2024)
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Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
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Published in Scientific reports (08.05.2024)
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Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
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Published in Synapse (New York, N.Y.) (15.06.2005)
Published in Synapse (New York, N.Y.) (15.06.2005)
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In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [ 3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine
Anderson, Jeffery J., Bradbury, Margaret J., Giracello, Darlene R., Chapman, Deborah F., Holtz, Greg, Roppe, Jeffrey, King, Chris, Cosford, Nicholas D.P., Varney, Mark A.
Published in European journal of pharmacology (18.07.2003)
Published in European journal of pharmacology (18.07.2003)
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[ 3H]-Methoxymethyl-MTEP and [ 3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor
Cosford, Nicholas D.P, Roppe, Jeffrey, Tehrani, Lida, Schweiger, Edwin J, Seiders, T.Jon, Chaudary, Ashok, Rao, Sara, Varney, Mark A
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization
Symons, Kent T, Massari, Mark E, Nguyen, Phan M, Lee, Tom T, Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E, Smith, Nicholas D, Noble, Stewart A, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A
Published in Molecular pharmacology (01.07.2009)
Published in Molecular pharmacology (01.07.2009)
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5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
Roppe, Jeffrey R, Wang, Bowei, Huang, Dehua, Tehrani, Lida, Kamenecka, Theodore, Schweiger, Edwin J, Anderson, Jeffery J, Brodkin, Jesse, Jiang, Xiaohui, Cramer, Merryl, Chung, Janice, Reyes-Manalo, Grace, Munoz, Benito, Cosford, Nicholas D.P
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
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2-{2-[3-(Pyridin-3-yloxy)phenyl]-2 H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist
Huang, Dehua, Poon, Steve F., Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Reger, Thomas S., Roppe, Jeffrey R., Tehrani, Lida, Cosford, Nicholas D.P., Smith, Nicholas D.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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3-[Substituted]-5-(5-pyridin-2-yl-2 H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists
Tehrani, Lida R., Smith, Nicholas D., Huang, Dehua, Poon, Steve F., Roppe, Jeffrey R., Seiders, Thomas Jon, Chapman, Deborah F., Chung, Janice, Cramer, Merryl, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity
Smith, Nicholas D., Poon, Steve F., Huang, Dehua, Green, Mitchell, King, Christopher, Tehrani, Lida, Roppe, Jeffrey R., Chung, Janice, Chapman, Deborah P., Cramer, Merryl, Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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LPAR1 안타고니스트 및 이의 용도
XIONG YIFENG, VALDEZ LINO, ROPPE JEFFREY ROGER, CHEN AUSTIN CHIH YU, SCHRADER THOMAS
Year of Publication 08.04.2024
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Year of Publication 08.04.2024
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무스카린성 아세틸콜린 M1 수용체 길항제의 결정질 화합물
XIONG YIFENG, BRAVO YALDA, ROPPE JEFFREY, CHEN AUSTIN CHIH YU, BACCEI JILL MELISSA, SCHRADER THOMAS
Year of Publication 19.12.2023
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Year of Publication 19.12.2023
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Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand ^sup 11^C-BMT-136088 for Lung Imaging in Rhesus Monkeys
Gallezot, Jean-Dominique, Nabulsi, Nabeel B, Holden, Daniel, Lin, Shu-Fei, Labaree, David, Ropchan, Jim, Najafzadeh, Soheila, Donnelly, David J, Cao, Kai, Bonacorsi, Samuel, Seiders, Jon, Roppe, Jeffrey, Hayes, Wendy, Huang, Yiyun, Du, Shuyan, Carson, Richard E
Published in The Journal of nuclear medicine (1978) (01.02.2018)
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Published in The Journal of nuclear medicine (1978) (01.02.2018)
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무스카린성 아세틸콜린 M1 수용체 안타고니스트
XIONG YIFENG, BRAVO YALDA, ROPPE JEFFREY, CHEN AUSTIN CHIH YU, BACCEI JILL MELISSA, SCHRADER THOMAS
Year of Publication 12.07.2022
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Year of Publication 12.07.2022
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5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor
Stock, Nicholas S, Bain, Gretchen, Zunic, Jasmine, Li, Yiwei, Ziff, Jeannie, Roppe, Jeffrey, Santini, Angelina, Darlington, Janice, Prodanovich, Pat, King, Christopher D, Baccei, Christopher, Lee, Catherine, Rong, Haojing, Chapman, Charles, Broadhead, Alex, Lorrain, Dan, Correa, Lucia, Hutchinson, John H, Evans, Jilly F, Prasit, Peppi
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
Cosford, Nicholas D. P, Tehrani, Lida, Roppe, Jeffrey, Schweiger, Edwin, Smith, Nicholas D, Anderson, Jeffrey, Bristow, Linda, Brodkin, Jesse, Jiang, Xiaohui, McDonald, Ian, Rao, Sara, Washburn, Mark, Varney, Mark A
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11 C-BMT-136088 for Lung Imaging in Rhesus Monkeys
Gallezot, Jean-Dominique, Nabulsi, Nabeel B, Holden, Daniel, Lin, Shu-Fei, Labaree, David, Ropchan, Jim, Najafzadeh, Soheila, Donnelly, David J, Cao, Kai, Bonacorsi, Samuel, Seiders, Jon, Roppe, Jeffrey, Hayes, Wendy, Huang, Yiyun, Du, Shuyan, Carson, Richard E
Published in Journal of Nuclear Medicine (01.02.2018)
Published in Journal of Nuclear Medicine (01.02.2018)
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5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3- tert -Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 H -indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor
Stock, Nicholas S., Bain, Gretchen, Zunic, Jasmine, Li, Yiwei, Ziff, Jeannie, Roppe, Jeffrey, Santini, Angelina, Darlington, Janice, Prodanovich, Pat, King, Christopher D., Baccei, Christopher, Lee, Catherine, Rong, Haojing, Chapman, Charles, Broadhead, Alex, Lorrain, Dan, Correa, Lucia, Hutchinson, John H., Evans, Jilly F., Prasit, Peppi
Published in Journal of medicinal chemistry (08.12.2011)
Published in Journal of medicinal chemistry (08.12.2011)
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Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models
Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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