Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4
Wen, Bo, Roongta, Vikram, Liu, Liling, Moore, David J
Published in Drug metabolism and disposition (01.06.2014)
Published in Drug metabolism and disposition (01.06.2014)
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Journal Article
Discovering Drugs through Biological Transformation: Role of Pharmacologically Active Metabolites in Drug Discovery
Fura, Aberra, Shu, Yue-Zhong, Zhu, Mingshe, Hanson, Ronald L, Roongta, Vikram, Humphreys, W. Griffith
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Journal Article
Disposition of [1'-14C]Stavudine after Oral Administration to Humans
LIAN ZHOU, KAUL, Sanjeev, LIU-KREYCHE, Peggy, TRAN, Scott B, ESPINA, Robert R, WARRACK, Bethanne M, ROONGTA, Vikram A, LYER, Ramaswamy A
Published in Drug metabolism and disposition (01.04.2010)
Published in Drug metabolism and disposition (01.04.2010)
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Journal Article
AMIDE N-GLUCURONIDATION OF MAXIPOST CATALYZED BY UDP-GLUCURONOSYLTRANSFERASE 2B7 IN HUMANS
DONGLU ZHANG, WEIPING ZHAO, ROONGTA, Vikram A, MITROKA, James G, KLUNK, Lewis J, MINGSHE ZHU
Published in Drug metabolism and disposition (01.05.2004)
Published in Drug metabolism and disposition (01.05.2004)
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Journal Article
PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS
DONGLU ZHANG, OGAN, Marc, GEDAMKE, Richard, ROONGTA, Vikram, DAI, Renke, MINGSHE ZHU, RINEHART, J. Kent, KLUNK, Lewis, MITROKA, James
Published in Drug metabolism and disposition (01.07.2003)
Published in Drug metabolism and disposition (01.07.2003)
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Journal Article
In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor
Zhang, Donglu, Hanson, Ronald, Roongta, Vikram, Dischino, Douglas D, Gao, Qi, Sloan, Charles P, Polson, Craig, Keavy, Daniel, Zheng, Ming, Mitroka, James, Yeola, Suresh
Published in Current drug metabolism (01.12.2006)
Published in Current drug metabolism (01.12.2006)
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Journal Article
Metabolism of [14C]Omapatrilat, a Sulfhydryl-Containing Vasopeptidase Inhibitor in Humans
Ramaswamy A. Iyer, James Mitroka, Bimal Malhotra, Samuel Bonacorsi, Jr, Stephen C. Waller, J. Kent Rinehart, Vikram A. Roongta, Kishin Kripalani
Published in Drug metabolism and disposition (01.01.2001)
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Published in Drug metabolism and disposition (01.01.2001)
Journal Article
A validated HPLC–MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: Application to a clinical pharmacokinetic study
Furlong, Michael T., Savant, Ishani, Yuan, Moucun, Scott, Laura, Mylott, William, Mariannino, Thomas, Kadiyala, Pathanjali, Roongta, Vikram, Arnold, Mark E.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2013)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2013)
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Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists
Sidduri, Achyutharao, Budd, David C., Fuentes, Maria E., Lambros, Ted, Ren, Yonglin, Roongta, Vikram, Schoenfeld, Ryan C., Gillespie, Paul, Stevenson, Christopher S., Truitt, Theresa, Qian, Yimin
Published in Bioorganic & medicinal chemistry letters (15.09.2014)
Published in Bioorganic & medicinal chemistry letters (15.09.2014)
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Journal Article
Metabolomic analysis using optimized NMR and statistical methods
Aranı´bar, Nelly, Ott, Karl-Heinz, Roongta, Vikram, Mueller, Luciano
Published in Analytical biochemistry (01.08.2006)
Published in Analytical biochemistry (01.08.2006)
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Journal Article
LC-MS/MS Method for the Quantitative Determination of Tanespimycin and its Active Metabolite in Human Plasma: Method Validation and Overcoming an Insidious APCI Source Phenomenon
Faria, Morse, Ismaiel, Omnia, Waltrip, James, Mariannino, Tom, Yuan, Moucun, Mylott, William, Roongta, Vikram, Shen, Jim, Kadiya, Pathanjali
Published in Journal of applied bioanalysis (15.08.2020)
Published in Journal of applied bioanalysis (15.08.2020)
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Journal Article
Eosinophil Peroxidase Oxidation of Thiocyanate
Arlandson, Mary, Decker, Troy, Roongta, Vikram A., Bonilla, Leo, Mayo, Kevin H., MacPherson, Jennifer C., Hazen, Stanley L., Slungaard, Arne
Published in The Journal of biological chemistry (05.01.2001)
Published in The Journal of biological chemistry (05.01.2001)
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Journal Article
Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations
Yang, Zheng, Vakkalagadda, Blisse, Shen, Guoxiang, Ahlers, Christoph M, Has, Teresa, Christopher, Lisa J, Kurland, John F, Roongta, Vikram, Masson, Eric, Zhang, Steven
Published in Journal of clinical pharmacology (01.02.2013)
Published in Journal of clinical pharmacology (01.02.2013)
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Journal Article
Effect of distortions in the deoxyribose phosphate backbone conformation of duplex oligodeoxyribonucleotide dodecamers containing GT, GG, GA, AC, and GU base-pair mismatches on phosphorus-31 NMR spectra
Roongta, Vikram A, Jones, Claude R, Gorenstein, David G
Published in Biochemistry (Easton) (05.06.1990)
Published in Biochemistry (Easton) (05.06.1990)
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Journal Article
Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans
CHRISTOPHER, Lisa J, HAIZHENG HONG, LYER, Ramaswamy A, HUMPHREYS, William G, TAI WONG, ZHANG, Steven, VAKKALAGADDA, Blisse J, CLEMENS, Pamela L, HONG SU, ROONGTA, Vikram, ALLENTOFF, Alban, HAOJUN SUN, HELLER, Kevin, HARBISON, Christopher T
Published in Drug metabolism and disposition (01.11.2010)
Published in Drug metabolism and disposition (01.11.2010)
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Journal Article
Food increased the bioavailability of BMS-690514, an orally active EGFR/HER2/VEGF receptor kinase inhibitor, in healthy subjects
Vakkalagadda, Blisse, Park, Jong-Soon, Ahlers, Christoph M, Dorizio, Stephanie, Has, Teresa, Roongta, Vikram, Heller, Kevin N, Derbin, George M, Zhang, Steven
Published in Journal of clinical pharmacology (01.09.2012)
Published in Journal of clinical pharmacology (01.09.2012)
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Journal Article
Mechanistic Studies on a P450-Mediated Rearrangement of BMS-690514: Conversion of a Pyrrolotriazine to a Hydroxypyridotriazine
Hong, Haizheng, Caceres-Cortes, Janet, Su, Hong, Huang, Xiaohua, Roongta, Vikram, Bonacorsi, Samuel, Hong, Yang, Tian, Yuan, Iyer, Ramaswamy A, Humphreys, W. Griffith, Christopher, Lisa J
Published in Chemical research in toxicology (14.01.2011)
Published in Chemical research in toxicology (14.01.2011)
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Journal Article
Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system
Arlandson, M, Decker, T, Roongta, V A, Bonilla, L, Mayo, K H, MacPherson, J C, Hazen, S L, Slungaard, A
Published in The Journal of biological chemistry (05.01.2001)
Published in The Journal of biological chemistry (05.01.2001)
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