Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship
Vianello, Paola, Sartori, Luca, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Vultaggio, Stefania, Zagarrí, Elisa, Varasi, Mario, Mercurio, Ciro
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration
Sartori, Luca, Mercurio, Ciro, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Vultaggio, Stefania, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Zagarrí, Elisa, Carettoni, Daniele, Iuzzolino, Lucia, Varasi, Mario, Vianello, Paola
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
Romussi, Alessia, Cappa, Anna, Vianello, Paola, Brambillasca, Silvia, Cera, Maria Rosaria, Dal Zuffo, Roberto, Fagà, Giovanni, Fattori, Raimondo, Moretti, Loris, Trifirò, Paolo, Villa, Manuela, Vultaggio, Stefania, Cecatiello, Valentina, Pasqualato, Sebastiano, Dondio, Giulio, So, Chi Wai Eric, Minucci, Saverio, Sartori, Luca, Varasi, Mario, Mercurio, Ciro
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
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Journal Article
New Selective Phosphodiesterase 4D Inhibitors Differently Acting on Long, Short, and Supershort Isoforms
Bruno, Olga, Romussi, Alessia, Spallarossa, Andrea, Brullo, Chiara, Schenone, Silvia, Bondavalli, Francesco, Vanthuyne, Nicolas, Roussel, Christian
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Journal Article
Relative stereochemistry of a diterpene from Salvia cinnabarina
Bisio, Angela, Pagano, Bruno, Romussi, Alessia, Bruno, Olga, De Tommasi, Nunziatina, Romussi, Giovanni, Mattia, Carlo Andrea
Published in Molecules (Basel, Switzerland) (10.10.2007)
Published in Molecules (Basel, Switzerland) (10.10.2007)
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Enrichment of DNA replication intermediates by EdU pull down
Pessina, Fabio, Romussi, Alessia, Piccini, Daniele, Mazzucco, Giulia, Varasi, Mario, Doksani, Ylli
Published in Methods in cell biology (2024)
Published in Methods in cell biology (2024)
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Journal Article
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment
Brullo, Chiara, Ricciarelli, Roberta, Prickaerts, Jos, Arancio, Ottavio, Massa, Matteo, Rotolo, Chiara, Romussi, Alessia, Rebosio, Claudia, Marengo, Barbara, Pronzato, Maria Adelaide, van Hagen, Britt T.J., van Goethem, Nick P., D'Ursi, Pasqualina, Orro, Alessandro, Milanesi, Luciano, Guariento, Sara, Cichero, Elena, Fossa, Paola, Fedele, Ernesto, Bruno, Olga
Published in European journal of medicinal chemistry (29.11.2016)
Published in European journal of medicinal chemistry (29.11.2016)
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Journal Article
THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
ZAGARRI, Elisa, VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, MORETTI, Loris, VILLA, Manuela, SARTORI, Luca, MERCURIO, Ciro, ROMUSSI, Alessia, MERONI, Giuseppe
Year of Publication 22.02.2023
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Year of Publication 22.02.2023
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Imidazoles as histone demethylase inhibitors
Trifiro', Paolo, Mercurio, Ciro, Romussi, Alessia, Varasi, Mario, Vianello, Paola, Cappa, Anna, Sartori, Luca
Year of Publication 08.07.2021
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Year of Publication 08.07.2021
Patent
Imidazoles as histone demethylase inhibitors
Trifiro′, Paolo, Mercurio, Ciro, Romussi, Alessia, Varasi, Mario, Vianello, Paola, Cappa, Anna, Sartori, Luca
Year of Publication 30.03.2021
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Year of Publication 30.03.2021
Patent
IMIDAZOLER SOM HISTONDEMETHYLASE-INHIBITORER
VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, ROMUSSI, Alessia, TRIFIRO', Paolo, SARTORI, Luca, MERCURIO, Ciro
Year of Publication 01.03.2021
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Year of Publication 01.03.2021
Patent
IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, ROMUSSI, Alessia, TRIFIRO', Paolo, SARTORI, Luca, MERCURIO, Ciro
Year of Publication 09.12.2020
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Year of Publication 09.12.2020
Patent
IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, ROMUSSI, Alessia, TRIFIRO', Paolo, SARTORI, Luca, MERCURIO, Ciro
Year of Publication 24.09.2020
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Year of Publication 24.09.2020
Patent
Derivados de morfolina que tienen una actividad de inhibición selectiva de PDE4D
BRULLO, Chiara, FEDELE, Ernesto, RICCIARELLI, Roberta, BRUNO, Olga, PRICKAERTS, Jos, ROMUSSI, Alessia, ARANCIO, Ottavio
Year of Publication 24.04.2020
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Year of Publication 24.04.2020
Patent
Imidazoles as histone demethylase inhibitors
Trifiro', Paolo, Mercurio, Ciro, Romussi, Alessia, Varasi, Mario, Vianello, Paola, Cappa, Anna, Sartori, Luca
Year of Publication 18.02.2020
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Year of Publication 18.02.2020
Patent
MORPHOLINE DERIVATIVES HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY
BRULLO, Chiara, FEDELE, Ernesto, RICCIARELLI, Roberta, BRUNO, Olga, PRICKAERTS, Jos, ROMUSSI, Alessia, ARANCIO, Ottavio
Year of Publication 07.08.2019
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Year of Publication 07.08.2019
Patent
IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, ROMUSSI, Alessia, TRIFIRO', Paolo, SARTORI, Luca, MERCURIO, Ciro
Year of Publication 23.05.2019
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Year of Publication 23.05.2019
Patent
IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
VARASI, Mario, CAPPA, Anna, VIANELLO, Paola, ROMUSSI, Alessia, TRIFIRO', Paolo, SARTORI, Luca, MERCURIO, Ciro
Year of Publication 27.03.2019
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Year of Publication 27.03.2019
Patent
Imidazoles as histone demethylase inhibitors
Trifiro', Paolo, Mercurio, Ciro, Romussi, Alessia, Varasi, Mario, Vianello, Paola, Cappa, Anna, Sartori, Luca
Year of Publication 17.01.2019
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Year of Publication 17.01.2019
Patent
Compounds having a selective PDE4D inhibiting activity
Arancio, Ottavio, Romussi, Alessia, Ricciarelli, Roberta, Bruno, Olga, Prickaerts, Jos, Brullo, Chiara, Fedele, Ernesto
Year of Publication 10.07.2018
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Year of Publication 10.07.2018
Patent