CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models
Drake, Penelope M, Carlson, Adam, McFarland, Jesse M, Bañas, Stefanie, Barfield, Robyn M, Zmolek, Wesley, Kim, Yun Cheol, Huang, Betty C B, Kudirka, Romas, Rabuka, David
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates
Kudirka, Romas A, Barfield, Robyn M, McFarland, Jesse M, Drake, Penelope M, Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W, Rabuka, David
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile
Kim, Han K, Monnier, Justin, Fu, Chi-Ling, Zhou, Matthew, Melrose, Jennifer E, Dao, Hung, Ponath, Paul D, McEachin, Katelynn A, Omstead, David T, Kreder, Cindy, Chun, Stefan, Lee, Ying Yueh, Grgich, Rachel, Lin, Tracey J, Walker, Joshua A, Henning, Karla A, Kudirka, Romas, Ackerman, Shelley E, Carrera, Diane, Chapin, Steven J, Mallet, William, Jackson, Dowdy, Gao, Changshou, Alonso, Michael N
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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784 BDC-2034: discovery of a CEA-targeting immune-stimulating antibody conjugate (ISAC) for solid tumors
Mallet, William, Gadkari, Rishali, Pearson, Cecelia, Torrez Dulgeroff, Laughing Bear, Luo, Angela, Luo, AAngela Luondrew, Melrose, Jennifer, Nolin, Jess, Lee, Arthur, Zhou, Matthew, Anand, Puneet, Sarma, Ganapathy, Henning, Karla, Blum, Lisa, Chapin, Steven, Bogaert, Liz, Ackerman, Shelley, Kudirka, Romas, Shen, Yuyi, Husain, Amreen, Perez, Edith, Kowanetz, Marcin, Alonso, Michael, Safina, Brian, Dornan, David
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes
Drake, Penelope M, Albers, Aaron E, Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M, Bhat, Abhijit S, de Hart, Gregory W, Garofalo, Albert W, Holder, Patrick, Jones, Lesley C, Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David
Published in Bioconjugate chemistry (16.07.2014)
Published in Bioconjugate chemistry (16.07.2014)
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Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates
Agarwal, Paresh, Kudirka, Romas, Albers, Aaron E, Barfield, Robyn M, de Hart, Gregory W, Drake, Penelope M, Jones, Lesley C, Rabuka, David
Published in Bioconjugate chemistry (19.06.2013)
Published in Bioconjugate chemistry (19.06.2013)
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Shaken, Not Stirred: Collapsing a Peptoid Monolayer To Produce Free-Floating, Stable Nanosheets
Sanii, Babak, Kudirka, Romas, Cho, Andrew, Venkateswaran, Neeraja, Olivier, Gloria K, Olson, Alexander M, Tran, Helen, Harada, R. Marika, Tan, Li, Zuckermann, Ronald N
Published in Journal of the American Chemical Society (28.12.2011)
Published in Journal of the American Chemical Society (28.12.2011)
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Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates
Albers, Aaron E., Garofalo, Albert W., Drake, Penelope M., Kudirka, Romas, de Hart, Gregory W., Barfield, Robyn M., Baker, Jeanne, Banas, Stefanie, Rabuka, David
Published in European journal of medicinal chemistry (17.12.2014)
Published in European journal of medicinal chemistry (17.12.2014)
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Folding of a single-chain, information-rich polypeptoid sequence into a highly ordered nanosheet
Kudirka, Romas, Tran, Helen, Sanii, Babak, Nam, Ki Tae, Choi, Philip H., Venkateswaran, Neeraja, Chen, Ritchie, Whitelam, Stephen, Zuckermann, Ronald N.
Published in Biopolymers (2011)
Published in Biopolymers (2011)
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Abstract 2911: The CEA-targeted ISAC, BDC-2034, shows preclinical efficacy associated with innate immune activation, phagocytosis, and myeloid reprogramming
Blum, Lisa K., Pearson, Cecelia I., Dulgeroff, Laughing Bear Torrez, Gadkari, Rishali, Luo, Angela, Luo, Andrew, Melrose, Jennifer E., Nolin, Jess L., Li, Hai, Lee, Arthur, Zhou, Matthew N., Anand, Puneet, Sarma, Ganapathy, Henning, Karla A., Chapin, Steven J., Ackerman, Shelley E., Kudirka, Romas, Shen, Yuyi, Hug, Bruce, Perez, Edith A., Kowanetz, Marcin, Alonso, Michael N., Safina, Brian S., Dornan, David, Mallet, William G.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 4252: PD-L1-targeted ISAC combines myeloid cell activation, immune-checkpoint inhibition and ADCP to improve anti-tumor efficacy over anti-PD-L1 antibodies in preclinical models
Kenkel, Justin A., Gadkari, Rishali, Ho, Po Y., Blum, Lisa K., Kudirka, Romas, Henning, Karla A., Mallet, William G., Melrose, Jennifer E., Sarma, Ganapathy, Chapin, Steven J., Zhou, Matthew, Deol, Suprit, Kreder, Cindy, Shen, Yuyi, Hug, Bruce, Anand, Puneet, Lee, Arthur, Li, Hai, Ackerman, Shelley E., Safina, Brian S., Dornan, David, Alonso, Michael N., Kowanetz, Marcin
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Creating Peptoid Nanosheets by Buckling a Gibbs Monolayer
Sanii, Babak, Kudirka, Romas, Cho, Andrew, Tran, Helen, Tan, Li, Zuckermann, Ron N.
Published in Biophysical journal (01.02.2011)
Published in Biophysical journal (01.02.2011)
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