Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
ABDI, Muna H, BESWICK, Paul J, LEJEUNE, Clarisse L, LIVERMORE, David G, MEDHURST, Stephen J, MICHEL, Anton D, MOSES, Andrew P, PAGE, Lee, PATEL, Sadhana, ROMAN, Shilina A, SENGER, Stefan, SLINGSBY, Brian, BILLINTON, Andy, STEADMAN, Jon G. A, STEVENS, Alexander J, WALTER, Daryl S, CHAMBERS, Laura J, CHARLTON, Andrew, COLLINS, Sue D, COLLIS, Katharine L, DEAN, David K, FONFRIA, Elena, GLEAVE, Robert J
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists
GLEAVE, Robert J, WALTER, Daryl S, BESWICK, Paul J, FONFRIA, Elena, MICHEL, Anton D, ROMAN, Shilina A, TANG, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists
Gleave, Robert J, Walter, Daryl S, Beswick, Paul J, Fonfria, Elena, Michel, Anton D, Roman, Shilina A, Tang, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Journal Article
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J, Billinton, Andy, Collis, Katharine L, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G A, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J., Billinton, Andy, Collis, Katharine L., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G.A., Walter, Daryl S.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor
Beswick, Paul J, Billinton, Andy, Chambers, Laura J, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Roomans, Sue, Senger, Stefan, Stevens, Alexander J, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
CHAMBERS, Laura J, STEVENS, Alexander J, THEOBALD, Pam J, BESWICK, Paul J, GLEAVE, Robert J, ROMAN, Shilina A, SENGER, Stefan, MOSES, Andrew P, MICHEL, Anton D, WALTER, Daryl S, DAVIES, David J, LIVERMORE, David G, FONFRIA, Elena, DEMONT, Emmanuel H, VIMAL, Mythily
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Mechanism of action of species‐selective P2X7 receptor antagonists
Michel, Anton D, Ng, Sin‐Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Structure–activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
Beswick, Paul J., Billinton, Andy, Chambers, Laura J., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Roomans, Sue, Senger, Stefan, Stevens, Alexander J., Walter, Daryl S.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Abstract 1730: A translational platform using primary human immune cells in vitro, syngeneic and humanized models in vivo to support and advance immuno-oncology drug discovery
O'Rourke, Martin, Roman, Shilina, Salmon, Gary, Waddell, Ian, Schueler, Julia, Wood, Edgar
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2811: A translational immuno-oncology platform to model the tumor microenvironment in vitro
Brackenbury, Louise S., Jenkinson, S. Rhiannon, Roman, Shilina, Nunan, Robert D., Hunt, Sylvie D., Willox, Anna, Williams, Neil A., Aziz, Omar, Waddell, Ian
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Mechanism of action of species-selective P2X(7) receptor antagonists
Michel, Anton D, Ng, Sin-Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Mechanism of action of species‐selective P2X 7 receptor antagonists
Michel, Anton D, Ng, Sin‐Wei, Roman, Shilina, Clay, William C, Dean, David K, Walter, Daryl S
Published in British journal of pharmacology (01.04.2009)
Published in British journal of pharmacology (01.04.2009)
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Journal Article
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X 7 receptor antagonist: a prospective genotyping approach
McHugh, Simon M., Roman, Shilina, Davis, Bill, Koch, Annelize, Pickett, Alison M., Richardson, Jill C., Miller, Sam R., Wetten, Sally, Cox, Charles J., Karpe, Fredrik, Todd, John A., Bullmore, Edward T.
Published in British journal of clinical pharmacology (01.08.2012)
Published in British journal of clinical pharmacology (01.08.2012)
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Journal Article
Abstract A143: A preclinical in vivo model to assess pharmacodynamic inhibition of ACK1
Albertella, Mark, Roman, Shilina, Briggs, Mike, Cranston, Aaron, Graeser, Ralph, Hynd, George, Jones, David, Lockey, Peter, Malik, Akbor, Price, Stephen, Stimpson, Susanna, Tisselli, Patrizia, Arts, Janine, Green, Simon
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X7 receptor antagonist: a prospective genotyping approach
McHugh, Simon M., Roman, Shilina, Davis, Bill, Koch, Annelize, Pickett, Alison M., Richardson, Jill C., Miller, Sam R., Wetten, Sally, Cox, Charles J., Karpe, Fredrik, Todd, John A., Bullmore, Edward T.
Published in British journal of clinical pharmacology (01.08.2012)
Published in British journal of clinical pharmacology (01.08.2012)
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Journal Article
Autoradiographical imaging of PPARγ agonist effects on PBR/TSPO binding in TASTPM mice
Roberts, Jennifer C., Friel, Sarah L., Roman, Shilina, Perren, Marion, Harper, Alex, Davis, John B., Richardson, Jill C., Virley, David, Medhurst, Andrew D.
Published in Experimental neurology (01.04.2009)
Published in Experimental neurology (01.04.2009)
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Journal Article
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X sub(7) antagonists
Gleave, Robert J, Walter, Daryl S, Beswick, Paul J, Fonfria, Elena, Michel, Anton D, Roman, Shilina A, Tang, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Journal Article