A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
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Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial
Harrison, Stephen A., Ruane, Peter J., Freilich, Bradley L., Neff, Guy, Patil, Rashmee, Behling, Cynthia A., Hu, Chen, Fong, Erica, de Temple, Brittany, Tillman, Erik J., Rolph, Timothy P., Cheng, Andrew, Yale, Kitty
Published in Nature medicine (01.07.2021)
Published in Nature medicine (01.07.2021)
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Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates
Kim, Albert M., Somayaji, Veena R., Dong, Jennifer Q., Rolph, Timothy P., Weng, Yan, Chabot, Jeffrey R., Gropp, Kathryn E., Talukdar, Saswata, Calle, Roberto A.
Published in Diabetes, obesity & metabolism (01.12.2017)
Published in Diabetes, obesity & metabolism (01.12.2017)
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Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export
White, Phillip J, Lapworth, Amanda L, An, Jie, Wang, Liping, McGarrah, Robert W, Stevens, Robert D, Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J, Bain, James R, Trimmer, Jeff K, Brosnan, M. Julia, Rolph, Timothy P, Newgard, Christopher B
Published in Molecular metabolism (Germany) (01.07.2016)
Published in Molecular metabolism (Germany) (01.07.2016)
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Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
Glynn, Erin L., Piner, Lucy W., Huffman, Kim M., Slentz, Cris A., Elliot-Penry, Lorraine, AbouAssi, Hiba, White, Phillip J., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga R., Stevens, Robert D., Porter Starr, Kathryn N., Bales, Connie W., Volpi, Elena, Brosnan, M. Julia, Trimmer, Jeff K., Rolph, Timothy P., Newgard, Christopher B., Kraus, William E.
Published in Diabetologia (01.10.2015)
Published in Diabetologia (01.10.2015)
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The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins
Davies, Michael N., Kjalarsdottir, Lilja, Thompson, J. Will, Dubois, Laura G., Stevens, Robert D., Ilkayeva, Olga R., Brosnan, M. Julia, Rolph, Timothy P., Grimsrud, Paul A., Muoio, Deborah M.
Published in Cell reports (Cambridge) (12.01.2016)
Published in Cell reports (Cambridge) (12.01.2016)
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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion
White, Phillip J., Lapworth, Amanda L., McGarrah, Robert W., Kwee, Lydia Coulter, Crown, Scott B., Ilkayeva, Olga, An, Jie, Carson, Matthew W., Christopher, Bridgette A., Ball, James R., Davies, Michael N., Kjalarsdottir, Lilja, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Koves, Timothy R., Muoio, Deborah M., Brozinick, Joseph T., Gimeno, Ruth E., Brosnan, M. Julia, Rolph, Timothy P., Kraus, William E., Shah, Svati H., Newgard, Christopher B.
Published in Cell reports (Cambridge) (10.11.2020)
Published in Cell reports (Cambridge) (10.11.2020)
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
Ferdaoussi, Mourad, Dai, Xiaoqing, Jensen, Mette V, Wang, Runsheng, Peterson, Brett S, Huang, Chao, Ilkayeva, Olga, Smith, Nancy, Miller, Nathanael, Hajmrle, Catherine, Spigelman, Aliya F, Wright, Robert C, Plummer, Gregory, Suzuki, Kunimasa, Mackay, James P, van de Bunt, Martijn, Gloyn, Anna L, Ryan, Terence E, Norquay, Lisa D, Brosnan, M Julia, Trimmer, Jeff K, Rolph, Timothy P, Kibbey, Richard G, Manning Fox, Jocelyn E, Colmers, William F, Shirihai, Orian S, Neufer, P Darrell, Yeh, Edward T H, Newgard, Christopher B, MacDonald, Patrick E
Published in The Journal of clinical investigation (01.10.2015)
Published in The Journal of clinical investigation (01.10.2015)
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The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats
Erion, Derek M, Lapworth, Amanda, Amor, Paul A, Bai, Guoyun, Vera, Nicholas B, Clark, Ronald W, Yan, Qingyun, Zhu, Yimin, Ross, Trenton T, Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D'Aquila, Theresa, Robertson, Alan, Aiello, Robert J, Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P, Pfefferkorn, Jeffrey A
Published in PloS one (23.05.2014)
Published in PloS one (23.05.2014)
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Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin
Kinne, Adam S., Tillman, Erik J., Abdeen, Sanofar J., Johnson, Derrick E., Parmer, Elijah S., Hurst, Jacob P., de Temple, Brittany, Rinker, Sherri, Rolph, Timothy P., Bowsher, Ronald R.
Published in Journal of pharmaceutical and biomedical analysis (05.08.2023)
Published in Journal of pharmaceutical and biomedical analysis (05.08.2023)
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Do ENSO and Coastal Development Enhance Coastal Burial of Terrestrial Carbon?
Macreadie, Peter I, Rolph, Timothy C, Boyd, Ron, Schröder-Adams, Claudia J, Skilbeck, Charles G
Published in PloS one (21.12.2015)
Published in PloS one (21.12.2015)
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Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
Esler, William P, Tesz, Gregory J, Hellerstein, Marc K, Beysen, Carine, Sivamani, Raja, Turner, Scott M, Watkins, Steven M, Amor, Paul A, Carvajal-Gonzalez, Santos, Geoly, Frank J, Biddle, Kathleen E, Purkal, Julie J, Fitch, Mark, Buckeridge, Clare, Silvia, Annette M, Griffith, David A, Gorgoglione, Matthew, Hassoun, Lauren, Bosanac, Suzana S, Vera, Nicholas B, Rolph, Timothy P, Pfefferkorn, Jeffrey A, Sonnenberg, Gabriele E
Published in Science translational medicine (15.05.2019)
Published in Science translational medicine (15.05.2019)
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FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
Bernardo, Barbara, Lu, Min, Bandyopadhyay, Gautam, Li, Pingping, Zhou, Yingjiang, Huang, Jie, Levin, Nancy, Tomas, Eva M., Calle, Roberto A., Erion, Derek M., Rolph, Timothy P., Brenner, Martin, Talukdar, Saswata
Published in Scientific reports (08.07.2015)
Published in Scientific reports (08.07.2015)
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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
Ahn, Kay, Boehm, Markus, Brown, Matthew F, Calloway, Jessica, Che, Ye, Chen, Jinshan, Fennell, Kimberly F, Geoghegan, Kieran F, Gilbert, Adam M, Gutierrez, Jemy A, Kalgutkar, Amit S, Lanba, Adhiraj, Limberakis, Chris, Magee, Thomas V, O’Doherty, Inish, Oliver, Robert, Pabst, Brandon, Pandit, Jayvardhan, Parris, Kevin, Pfefferkorn, Jeffrey A, Rolph, Timothy P, Patel, Rushi, Schuff, Brandon, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Varghese, Alison H, Vera, Nicholas B, Vernochet, Cecile, Yan, Jiangli
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Mineral magnetism and geomagnetic secular variation of marine and lacustrine sediments from central Italy: timing and nature of local and regional Holocene environmental change
Rolph, Timothy C, Vigliotti, Luigi, Oldfield, Frank
Published in Quaternary science reviews (01.07.2004)
Published in Quaternary science reviews (01.07.2004)
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Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?
Ritchie, Michael, Hanouneh, Ibrahim A, Noureddin, Mazen, Rolph, Timothy, Alkhouri, Naim
Published in Expert opinion on investigational drugs (01.02.2020)
Published in Expert opinion on investigational drugs (01.02.2020)
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Decreases in cT1 and liver fat content reflect treatment-induced histological improvements in MASH
Alkhouri, Naim, Beyer, Cayden, Shumbayawonda, Elizabeth, Andersson, Anneli, Yale, Kitty, Rolph, Timothy, Chung, Raymond T., Vuppalanchi, Raj, Cusi, Kenneth, Loomba, Rohit, Pansini, Michele, Dennis, Andrea
Published in Journal of hepatology (19.09.2024)
Published in Journal of hepatology (19.09.2024)
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897-P: Insulin-Sensitizing Effects of Efruxifermin Improve Glycemic Control in Patients with MASH and Type 2 Diabetes
Lucas, K J, Harrison, Stephen A, Chan, Doreen, Tillman, Erik J, Moulton, Ali, De TEMPLE, Brittany, Zari, Arian, Shringarpure, Reshma, Rolph, Timothy, Cheng, Andrew, Yale, Kitty
Published in Diabetes (New York, N.Y.) (01.06.2024)
Published in Diabetes (New York, N.Y.) (01.06.2024)
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Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy
Scheele, Wim, Diamond, Susan, Gale, Jeremy, Clerin, Valerie, Tamimi, Nihad, Le, Vu, Walley, Rosalind, Grover-Páez, Fernando, Perros-Huguet, Christelle, Rolph, Timothy, El Nahas, Meguid
Published in Journal of the American Society of Nephrology (01.11.2016)
Published in Journal of the American Society of Nephrology (01.11.2016)
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