1334 OBT698: a promising novel agonistic antibody for immuno-oncology and its potential as a cancer therapy for solid tumors
Bisht, Arnima, Peddaboina, Chander, Carroll, Chantia, Haeske, Harald, Rohlff, Christian
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models
Gaudio, Eugenio, Tarantelli, Chiara, Spriano, Filippo, Guidetti, Francesca, Sartori, Giulio, Bordone, Roberta, Arribas, Alberto J, Cascione, Luciano, Bigioni, Mario, Merlino, Giuseppe, Fiascarelli, Alessio, Bressan, Alessandro, Mensah, Afua Adjeiwaa, Golino, Gaetanina, Lucchini, Renzo, Bernasconi, Elena, Rossi, Davide, Zucca, Emanuele, Stussi, Georg, Stathis, Anastasios, Boyd, Robert S, Dusek, Rachel L, Bisht, Arnima, Attanasio, Nickolas, Rohlff, Christian, Pellacani, Andrea, Binaschi, Monica, Bertoni, Francesco
Published in Haematologica (Roma) (01.11.2020)
Published in Haematologica (Roma) (01.11.2020)
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Journal Article
MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors
Merlino, Giuseppe, Fiascarelli, Alessio, Bigioni, Mario, Bressan, Alessandro, Carrisi, Corrado, Bellarosa, Daniela, Salerno, Massimiliano, Bugianesi, Rossana, Manno, Rosanna, Bernadó Morales, Cristina, Arribas, Joaquin, Dusek, Rachel L, Ackroyd, James E, Pham, Phuoc Huy, Awdew, Rahel, Aud, Dee, Trang, Michael, Lynch, Carmel M, Terrett, Jonathan, Wilson, Keith E, Rohlff, Christian, Manzini, Stefano, Pellacani, Andrea, Binaschi, Monica
Published in Molecular cancer therapeutics (01.09.2019)
Published in Molecular cancer therapeutics (01.09.2019)
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Journal Article
Targeting CD157 in AML using a novel, Fc-engineered antibody construct
Krupka, Christina, Lichtenegger, Felix S., Köhnke, Thomas, Bögeholz, Jan, Bücklein, Veit, Roiss, Michael, Altmann, Torben, Do, To Uyen, Dusek, Rachel, Wilson, Keith, Bisht, Arnima, Terrett, Jon, Aud, Dee, Pombo-Villar, Esteban, Rohlff, Christian, Hiddemann, Wolfgang, Subklewe, Marion
Published in Oncotarget (30.05.2017)
Published in Oncotarget (30.05.2017)
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Journal Article
Modulation of Transcription Factor Sp1 by cAMP-dependent Protein Kinase
Rohlff, Christian, Ahmad, Shakeel, Borellini, Flavia, Lei, Jun, Glazer, Robert I.
Published in The Journal of biological chemistry (22.08.1997)
Published in The Journal of biological chemistry (22.08.1997)
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Journal Article
Hyaluronidase gene profiling and role of HYAL‐1 overexpression in an orthotopic model of prostate cancer
Patel, Sonal, Turner, Paul R., Stubberfield, Colin, Barry, Eleanor, Rohlff, Christian R., Stamps, Alasdair, Tyson, Kerry, Terrett, Jon, Box, Gary, Eccles, Suzanne, Page, Martin J.
Published in International journal of cancer (01.02.2002)
Published in International journal of cancer (01.02.2002)
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Journal Article
Proteomics: a major new technology for the drug discovery process
Page, Martin J, Amess, Bob, Rohlff, Christian, Stubberfield, Colin, Parekh, Raj
Published in Drug Discovery Today (01.02.1999)
Published in Drug Discovery Today (01.02.1999)
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Book Review
Journal Article
Phase 1 study of OBT076, a first-in-class anti-DEC205 ADC, in patients with advanced/metastatic solid tumors: Safety, efficacy, and PK/PD results
Rixe, Olivier, Tang, Shou-Ching, Sahebjam, Solmaz, Mita, Monica M., Mita, Alain C., Rosen, Lee S., Bisht, Arnima, Fandi, Abderrahim, Rohlff, Christian, Mehta, Rutika
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Abstract LB429: Discovery and identification of a novel cancer associated fibroblast target using Oxford Biotherapeutics (OBTs) OGAP discovery platform
Sarnecky, Jeremy, Lewis, Joseph, Allen, Jason, Davies, Daniel, Metzger, Matthew, Thomas, Ben, Rohlff, Christian, Cairns, Belinda
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models
Gaudio, Eugenio, Tarantelli, Chiara, Spriano, Filippo, Guidetti, Francesca, Sartori, Giulio, Bordone, Roberta, Arribas, Alberto J, Cascione, Luciano, Bigioni, Mario, Merlino, Giuseppe, Fiascarelli, Alessio, Bressan, Alessandro, Adjeiwaa Mensah, Afua, Golino, Gaetanina, Lucchini, Renzo, Bernasconi, Elena, Rossi, Davide, Zucca, Emanuele, Stussi, Georg, Stathis, Anastasios, Boyd, Robert S, Dusek, Rachel L, Bisht, Arnima, Attanasio, Nickolas, Rohlff, Christian, Pellacani, Andrea, Binaschi, Monica, Bertoni, Francesco
Published in Haematologica (Roma) (01.11.2020)
Published in Haematologica (Roma) (01.11.2020)
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Journal Article
Abstract 5167: Identification and validation of a novel immuno-oncology target and selection of a therapeutic antibody candidate with a pharmacologically beneficial activity profile
Bisht, Arnima, Kaplan, Angelo, Deban, Livija, Peddaboina, Chander Sekhar, Cox, Murray, Hudson, Lindsey, Ackroyd, James, Attanasio, Nickolas, Lou, San Lin, Allen, Jason, Barnes, Martin, Boyd, Robert, Zhukovsky, Eugene, Fandi, Abderrahim, Rohlff, Christian
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 1069: OBT076, a clinical-stage ADC, displays synergy with oxaliplatin and cisplatin in preclinical gastric cancer models
Bisht, Arnima, Cox, Murray, Peddaboina, Chander Sekhar, Crocamo, Michael, Fandi, Abderrahim, Rohlff, Christian
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 753: The use of proteomics to analyse whole tumors and identify unique stroma cell targets for antibody-based therapeutics
Ackroyd, James, Allen, Jason, Berry, Jo, Roesch, Lisa, Barnes, Martin, Bisht, Arnima, Rohlff, Christian, Wilson, Keith, Aud, Dee, Boyd, Robert
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 2630: MEN1309, a novel antibody drug conjugate (ADC) targeting Ly75 antigen, induces complete responses in several xenografts of solid tumors
Bigioni, Mario, Merlino, Giuseppe, Morales, Cristina Bernadó, Bugianesi, Rossana, Crea, Attilio, Manno, Rosanna, Arribas, Joaquin, Dusek, Rachel, Attanasio, Nickolas, Wilson, Keith, Rohlff, Christian, Binaschi, Monica
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 3715: Analysis of tumor infiltrating lymphocytes and in vitro exhausted T-cell models to identify unique Immuno-Oncology targets
Ackroyd, James, Berry, Joanne, Fu, Yaoyao, Allen, Jason, Barnes, Martin, Patterson, Alexander, Kaplan, Angelo, Rohlff, Christian, Huang, Haining, Deban, Livija, Boyd, Robert
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 2772: Preclinical development of a novel antibody-drug conjugate targeting “cold” tumors
Kaplan, Angelo, Attanasio, Nickolas, Do, To Uyen T, Swaminathan, Sudha, Bisht, Arnima, Lou, San Lin, Allen, Jason, Boyd, Robert, Ackroyd, James E., Feldman, Gleb, Rohlff, Christian, Dusek, Rachel L.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2771: Harnessing novel immune escape mechanisms for cancer therapeutics: OXAB1 target validation, proof of concept and preclinical development
Deban, Livija, Cao, Wei, Fu, Yaoyao, Kaplan, Angelo, Duesk, Rachel L., Bisht, Arnima, Swaminathan, Sudha, Lou, San Lin, Amoury, Manal, Adelegan, Bukky, Berry, Joanne, Ackroyd, James E., Hannum, Chuck, Boyd, Robert, Rohlff, Christian, Huang, Haining
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Harnessing novel immune escape mechanisms for cancer therapeutics: OXAB1 target validation, proof of concept and preclinical development
Deban, Livija, Cao, Wei, Fu, Yaoyao, Kaplan, Angelo, Dusek, Rachel, Bisht, Arnima, Swaminathan, Sudha, Lou, San Lin, Amoury, Manal, Adelegan, Bukky, Berry, Joanne, Ackroyd, Jim, Hanum, Chuck, Boyd, Robert, Rohlff, Christian, Huang, Haining
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article